公开(公告)号：US11921183B2

公开(公告)日：2024-03-05

申请号：US15553933

申请日：2016-02-25

Applicant: King's College London

Inventor： Ralph Sinkus ,  Ondrej Holub ,  Simon Lambert ,  Rachel Clough

IPC: G01R33/563 ,  A61B5/00 ,  A61B5/055 ,  G01R33/28

CPC classification number: G01R33/56358 ,  A61B5/0051 ,  A61B5/055 ,  G01R33/28 ,  G01R33/56308

Abstract: A magnetic resonance (MR) compatible transducer for magnetic resonance elastography applications has a cantilevered drive element a free end of which is arranged in use to move reciprocally, and a flexible non-conductive connection rod slidably disposed within a flexible non-conductive sleeve. The connection rod is affixed at a proximal end to the cantilevered drive element via a proximal flexible connection piece that in use accommodates the slight rotational movement of the cantilevered drive element as it reciprocates about its secured end, whilst translating the rotational reciprocation of the cantilevered drive element into a pure translational reciprocation of the connection rod within the sleeve. The distal end of the connection rod is affixed against a protrusion connected to another cantilevered driven element, upon which is mounted a piston element that in use contacts the subject. The distal end of the connection rod is provided with a distal flexible connection piece that forms the connection between the end of the connection rod and the cantilevered driven element, again to account for the pure translational movement of the rod being converted to rotational movement of the cantilevered driven element about its cantilever pivot point.

公开(公告)号：US20230296708A1

公开(公告)日：2023-09-21

申请号：US17697492

申请日：2022-03-17

Applicant: Siemens Healthcare GmbH ,  Centre National de la Recherche Scientifique (CNRS) ,  Institut National de La Sante et de la Recherche Medicale (INSERM) ,  King's College London ,  Department of Health and Human Services ,  Univ Paris XIII Paris-Nord Villetaneuse ,  Universite de Paris

Inventor： Giacomo Annio ,  Verena Muller-Reinwald ,  Ralph Sinkus ,  Omar Darwish ,  Wilfried Schnell ,  Tamara Elisabeth Falkner ,  Ahmed M. Gharib

IPC: A61B6/04 ,  A61B5/055

CPC classification number: A61B6/0487 ,  A61B5/055 ,  G01R33/48

Abstract: The present disclosure is directed to a motor for a magnetic resonance (MR) tomography room, to a patient table for the MR room, to a MR elastography device, and to a MR tomography device. A MR tomography device for a MR elastography imaging protocol is arranged within the MR tomography room, and includes a rotational drive for supplying rotational energy to power a MR elastography transducer usable during the MR elastography imaging protocol, and a support structure. The rotational drive comprises a terminal for connecting the MR elastography transducer to the rotational drive, and a bearing means configured such that the position of the terminal relative to the support structure is adaptable along a trajectory predetermined by the bearing means. The rotational drive is mounted to the support structure via the bearing means.

公开(公告)号：US11852704B2

公开(公告)日：2023-12-26

申请号：US17697492

申请日：2022-03-17

Applicant: Siemens Healthcare GmbH ,  Centre National de la Recherche Scientifique (CNRS) ,  Institut National de La Sante et de la Recherche Medicale (INSERM) ,  King's College London ,  Department of Health and Human Services ,  UNIV PARIS XIII PARIS-NORD VILLETANEUSE ,  Universite de Paris

Inventor： Giacomo Annio ,  Verena Muller-Reinwald ,  Ralph Sinkus ,  Omar Darwish ,  Wilfried Schnell ,  Tamara Elisabeth Falkner ,  Ahmed M. Gharib

IPC: G01R33/48 ,  A61B5/055 ,  G01R33/563 ,  A61B5/00

CPC classification number: G01R33/48 ,  A61B5/055 ,  G01R33/56358 ,  A61B5/704

Abstract: The present disclosure is directed to a motor for a magnetic resonance (MR) tomography room, to a patient table for the MR room, to a MR elastography device, and to a MR tomography device. A MR tomography device for a MR elastography imaging protocol is arranged within the MR tomography room, and includes a rotational drive for supplying rotational energy to power a MR elastography transducer usable during the MR elastography imaging protocol, and a support structure. The rotational drive comprises a terminal for connecting the MR elastography transducer to the rotational drive, and a bearing means configured such that the position of the terminal relative to the support structure is adaptable along a trajectory predetermined by the bearing means. The rotational drive is mounted to the support structure via the bearing means.

公开(公告)号：US20230305090A1

公开(公告)日：2023-09-28

申请号：US17702212

申请日：2022-03-23

Applicant: Siemens Healthcare GmbH ,  Centre National de la Recherche Scientifique (CNRS) ,  Institut National de La Sante et de la Recherche Medicale (INSERM) ,  King's College London ,  Department of Health and Human Services ,  UNIV PARIS XIII PARIS-NORD VILLETANEUSE ,  Universite de Paris

Inventor： Omar Darwish ,  Radhouene Neji ,  Ahmed M. Gharib ,  Ralph Sinkus

IPC: G01R33/563 ,  G01R33/30 ,  H02P8/08 ,  H02P8/22

CPC classification number: G01R33/56358 ,  G01R33/30 ,  H02P8/08 ,  H02P8/22

Abstract: The present disclosure is directed to techniques for synchronizing a rotational eccentric mass of a gravitational transducer used for a magnetic resonance elastography acquisition with a corresponding magnetic resonance elastography scan carried out by a magnetic resonance imaging system, wherein the rotation of the eccentric mass is driven by a shaft. The method includes starting the rotation of the eccentric mass at a set vibration frequency and the magnetic resonance elastography scan at a set acquisition frequency; determining the rotational position of the shaft; defining the rotational position as first reference position; calculating further reference positions. At the start time of each subsequent acquisition period, determining the current rotational position of the shaft; comparing the determined current rotational position with the theoretically expected reference position and decreasing or increasing the rotational speed of the rotational eccentric mass based on the comparison.

公开(公告)号：US20220317219A1

公开(公告)日：2022-10-06

申请号：US17711335

申请日：2022-04-01

Applicant: Siemens Healthcare GmbH ,  King's College London

Inventor： Omar Darwish ,  Stephan Kannengiesser ,  Ralph Sinkus ,  Radhouene Neji

IPC: G01R33/563 ,  G01R33/56 ,  G01R33/561

Abstract: The present disclosure generally relate to a method and system for performing three-dimensional, 3D, magnetic resonance elastography, MRE. In particular, the present disclosure relates to a method and system for imaging an area of a patient using a multi-slice gradient echo, GRE, imaging sequence. Advantageously, the present techniques enable the four scans that are typically required to be performed during MRE, and during four breath-holds, to be combined into a single measurement that can be performed during a single breath-hold.

公开(公告)号：US20240012077A1

公开(公告)日：2024-01-11

申请号：US18474332

申请日：2023-09-26

Applicant: Siemens Healthcare GmbH ,  Centre National de la Recherche Scientifique (CNRS) ,  Institut National de La Sante et de la Recherche Medicale (INSERM) ,  King's College London ,  Department of Health and Human Services ,  UNIV PARIS XIII PARIS-NORD VILLETANEUSE ,  Universite de Paris

Inventor： Giacomo Annio ,  Verena Müller-Reinwald ,  Ralph Sinkus ,  Omar Darwish ,  Wilfried Schnell ,  Tamara Elisabeth Falkner ,  Ahmed M. Gharib

IPC: G01R33/48 ,  A61B5/055 ,  G01R33/563

CPC classification number: G01R33/48 ,  A61B5/055 ,  G01R33/56358 ,  A61B5/704

Abstract: The present disclosure is directed to a motor for a magnetic resonance (MR) tomography room, to a patient table for the MR room, to a MR elastography device, and to a MR tomography device. A MR tomography device for a MR elastography imaging protocol is arranged within the MR tomography room, and includes a rotational drive for supplying rotational energy to power a MR elastography transducer usable during the MR elastography imaging protocol, and a support structure. The rotational drive comprises a terminal for connecting the MR elastography transducer to the rotational drive, and a bearing means configured such that the position of the terminal relative to the support structure is adaptable along a trajectory predetermined by the bearing means. The rotational drive is mounted to the support structure via the bearing means.

公开(公告)号：US11821972B2

公开(公告)日：2023-11-21

申请号：US17702212

申请日：2022-03-23

Applicant: Siemens Healthcare GmbH ,  Centre National de la Recherche Scientifique (CNRS) ,  Institut National de La Sante et de la Recherche Medicale (INSERM) ,  King's College London ,  Department of Health and Human Services ,  UNIV PARIS XIII PARIS-NORD VILLETANEUSE ,  Universite de Paris

Inventor： Omar Darwish ,  Radhouene Neji ,  Ahmed M. Gharib ,  Ralph Sinkus

IPC: G01R33/30 ,  G01R33/563 ,  H02P8/22 ,  H02P8/08

CPC classification number: G01R33/56358 ,  G01R33/30 ,  H02P8/08 ,  H02P8/22

Abstract: The present disclosure is directed to techniques for synchronizing a rotational eccentric mass of a gravitational transducer used for a magnetic resonance elastography acquisition with a corresponding magnetic resonance elastography scan carried out by a magnetic resonance imaging system, wherein the rotation of the eccentric mass is driven by a shaft. The method includes starting the rotation of the eccentric mass at a set vibration frequency and the magnetic resonance elastography scan at a set acquisition frequency; determining the rotational position of the shaft; defining the rotational position as first reference position; calculating further reference positions. At the start time of each subsequent acquisition period, determining the current rotational position of the shaft; comparing the determined current rotational position with the theoretically expected reference position and decreasing or increasing the rotational speed of the rotational eccentric mass based on the comparison.

公开(公告)号：US11740312B2

公开(公告)日：2023-08-29

申请号：US17711335

申请日：2022-04-01

Applicant: Siemens Healthcare GmbH ,  King's College London

Inventor： Omar Darwish ,  Stephan Kannengießer ,  Ralph Sinkus ,  Radhouene Neji

IPC: G01R33/563 ,  G01R33/56 ,  G01R33/561

CPC classification number: G01R33/56358 ,  G01R33/5608 ,  G01R33/5611

Abstract: A method and system for performing three-dimensional, 3D, magnetic resonance elastography, MRE, using a multi-slice gradient echo, GRE, imaging sequence. Four scans typically required to be performed during MRE, and during four breath-holds, are combined into a single measurement that can be performed during a single breath-hold.

公开(公告)号：US20180172789A1

公开(公告)日：2018-06-21

申请号：US15553933

申请日：2016-02-25

Applicant: King's College London

Inventor： Ralph Sinkus ,  Ondrej Holub ,  Simon Lambert ,  Rachel Clough

IPC: G01R33/563 ,  A61B5/00 ,  G01R33/28 ,  A61B5/055

CPC classification number: G01R33/56358 ,  A61B5/0051 ,  A61B5/055 ,  G01R33/28 ,  G01R33/56308

Abstract: Embodiments of the invention provide a magnetic resonance (MR) compatible transducer for magnetic resonance elastography applications having a cantilevered drive element (54) a free end of which is arranged in use to move reciprocally, and a flexible non-conductive connection rod (62) slidably disposed within a flexible non-conductive sleeve (60). The connection rod is affixed at a proximal end to the cantilevered drive element via a proximal flexible connection piece (64) that in use accommodates the slight rotational movement of the cantilevered drive element as it reciprocates about its secured end, whilst translating the rotational reciprocation of the cantilevered drive element into a pure translational reciprocation of the connection rod within the sleeve. The distal end of the connection rod is affixed against a protrusion connected to another cantilevered driven element (56), upon which is mounted a piston element (58) that in use contacts the subject. The distal end of the connection rod is provided with a distal flexible connection piece that forms the connection between the end of the connection rod and the cantilevered driven element, again to account for the pure translational movement of the rod being converted to rotational movement of the cantilevered driven element about its cantilever pivot point.