公开(公告)号：US07138420B2

公开(公告)日：2006-11-21

申请号：US10632888

申请日：2003-08-01

申请人： Joerg Martin Bentzien ,  Brian Nicholas Cook ,  Charles Cywin ,  Roman Wolfgang Fleck ,  Ho Yin Lo ,  Peter Allen Nemoto ,  Steven S. Pullen ,  Gregory Paul Roth ,  Roger John Snow ,  Hidenori Takahashi ,  Ji Wang ,  Kevin J. Moriarty ,  Lei Qiao ,  Michael Winters

发明人： Joerg Martin Bentzien ,  Brian Nicholas Cook ,  Charles Cywin ,  Roman Wolfgang Fleck ,  Ho Yin Lo ,  Peter Allen Nemoto ,  Steven S. Pullen ,  Gregory Paul Roth ,  Roger John Snow ,  Hidenori Takahashi ,  Ji Wang ,  Kevin J. Moriarty ,  Lei Qiao ,  Michael Winters

IPC分类号： A61K31/4184 ,  C07D235/30

CPC分类号： C07D409/12 ,  C07D235/30

摘要： Disclosed are substituted benzimidazole compounds of formula (I): wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.

摘要翻译： 公开了式（I）的取代的苯并咪唑化合物：其中R 1，R 2，R 3，R 4， >和X > 。 本发明的化合物抑制Itk激酶，因此可用于治疗涉及炎症，免疫学障碍和过敏性疾病的疾病和病理状况。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。

公开(公告)号：US4986377A

公开(公告)日：1991-01-22

申请号：US376732

申请日：1989-07-07

申请人： Kevin J. Moriarty

发明人： Kevin J. Moriarty

IPC分类号： B60K17/342 ,  B60K17/348 ,  B60K17/356 ,  B62D55/06 ,  F16H59/50 ,  F16H61/452 ,  F16H61/46

CPC分类号： F16H61/452 ,  B60K17/348 ,  B60K17/356 ,  B62D55/06 ,  F16H61/46 ,  F16H2059/506

摘要： The invention is directed to an auxiliary drive system for the front wheels of a belted track crawler. The auxiliary drive wheels and the main drive wheels are provided with overrunning clutches. In the first two embodiments a mechanical system is used to drive the auxiliary wheels. In the third embodiment electric motors are used to drive the auxiliary wheels. With all the systems when the crawler is being driven forward the auxiliary drive wheel is driven slower than the main drive wheel. In a no slip situation the auxiliary drive wheel freely rotates at the speed of the main drive wheel. When sufficient slippage occurs between the main drive wheel and the track, the auxiliary drive wheel is driven at the slower speed driving the track. In reverse, the auxiliary drive wheel is driven faster than the main drive wheel. In a no slip condition, the auxiliary drive wheel drives the crawler in reverse. When sufficient slippage occurs between the auxiliary drive wheel and the belted track, the main drive wheel again drives the crawler.

摘要翻译： 本发明涉及一种用于带式履带履带机的前轮的辅助驱动系统。 辅助驱动轮和主驱动轮配有超越离合器。 在前两个实施例中，使用机械系统来驱动辅助轮。 在第三实施例中，电动机用于驱动辅助轮。 当履带被驱动向前时，所有的系统都驱动辅助驱动轮比主驱动轮慢。 在无滑动的情况下，辅助驱动轮以主驱动轮的速度自由旋转。 当主驱动轮和轨道之间发生足够的滑动时，辅助驱动轮以较慢的速度驱动轨道。 反过来，辅助驱动轮的驱动速度比主驱动轮快。 在无滑动状态下，辅助驱动轮反向驱动履带。 当辅助驱动轮和带轨之间发生足够的滑动时，主驱动轮再次驱动履带。

公开(公告)号：US20120232054A1

公开(公告)日：2012-09-13

申请号：US13266921

申请日：2010-04-28

申请人： Kevin J. Moriarty ,  Dora Do-York Wong ,  Zenon Konteatis ,  Kristofer Moffett ,  Younghee Lee ,  Wenchun Chao

发明人： Kevin J. Moriarty ,  Dora Do-York Wong ,  Zenon Konteatis ,  Kristofer Moffett ,  Younghee Lee ,  Wenchun Chao

IPC分类号： A61K31/53 ,  A61P37/06 ,  A61K31/5377 ,  A61P7/02 ,  A61P35/00 ,  C07D487/04 ,  A61P37/08 ,  A61P29/00

CPC分类号： A61K31/53 ,  C07D487/04 ,  A61K2300/00

摘要： A compound of formula (I): wherein all symbols have the same meanings as defined in the specification; a salt thereof, a solvate thereof, an N-oxide thereof, or a prodrug thereof, has a Btk inhibitory activity, and is useful as a method for preventing and/or treating a rheumatoid arthritis, an autoimmune disease, a B cell lymphoma of cancer, and the like.

摘要翻译： 式（I）的化合物：其中所有符号具有与说明书中定义的相同的含义; 其盐，其溶剂合物，N-氧化物或其前药具有Btk抑制活性，并且可用作预防和/或治疗类风湿性关节炎，自身免疫疾病，B细胞淋巴瘤的B细胞淋巴瘤 癌症等。

公开(公告)号：US4942934A

公开(公告)日：1990-07-24

申请号：US169528

申请日：1988-03-17

申请人： Kevin J. Moriarty

发明人： Kevin J. Moriarty

IPC分类号： B62D55/00 ,  B60K17/10 ,  B62D55/12 ,  F16H61/452 ,  F16H61/46 ,  F16H61/47

CPC分类号： F16H61/47 ,  B62D55/12 ,  F16H61/452 ,  F16H61/46

摘要： A crawler having a friction driven elastomeric belted track which is driven by rear mounted main drive wheels and front mounted auxiliary drive wheels. The auxiliary drive wheels are operatively coupled through hydraulic clutches to hydraulic motors that are fluidically coupled to a reversible variable displacement pump. An electronic controller controls the output of the pump so that the auxiliary drive wheels are driven at a speed less than the main drive wheels in the forward direction at a speed equal to or greater than the speed of the main drive wheels in the reverse direction. A valve assembly selectively couples and decouples the hydraulic clutches for engaging and disengaging the motor when turning the vehicle.

摘要翻译： 具有摩擦驱动弹性带轨的履带，其由后安装的主驱动轮和前安装的辅助驱动轮驱动。 辅助驱动轮通过液压离合器可操作地连接到流体耦合到可逆排量泵的液压马达。 电子控制器控制泵的输出，使得辅助驱动轮以等于或大于主驱动轮在相反方向上的速度的速度沿向前方向以小于主驱动轮的速度被驱动。 阀组件选择性地联接和解耦液压离合器，用于在转动车辆时接合和分离马达。