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公开(公告)号：US07241783B2
公开(公告)日：2007-07-10
申请号：US10451300
申请日：2001-12-19
申请人： Kevin J. Duffy , Juan I. Luengo , Stephen G. Miller , Julian Jenkins , Alan T. Price , Antony N. Shaw
发明人： Kevin J. Duffy , Juan I. Luengo , Stephen G. Miller , Julian Jenkins , Alan T. Price , Antony N. Shaw
IPC分类号： A61K31/427 , A61K31/4709 , A61K31/4152
CPC分类号： A61K31/275 , A61K31/04 , A61K31/045 , A61K31/05 , A61K31/13 , A61K31/131 , A61K31/175 , A61K31/325 , A61K31/415
摘要： Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected substituted thiosemicarbazone derivative.
摘要翻译： 发明的是非肽TPO模拟物。 还发明了一种在有需要的哺乳动物（包括人）中治疗血小板减少症的方法，其包括向所述哺乳动物施用有效量的选定的取代的缩氨基硫脲衍生物。
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公开(公告)号：US06552008B1
公开(公告)日：2003-04-22
申请号：US10110287
申请日：2002-03-22
申请人： Kevin J. Duffy , Nannan Liu , Juan I. Luengo
发明人： Kevin J. Duffy , Nannan Liu , Juan I. Luengo
IPC分类号： A61K31655
CPC分类号： C07D401/14 , C07D231/48
摘要： Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected azo-pyrazole derivative.
摘要翻译： 发明的是非肽TPO模拟物。 还发明了一种在有需要的哺乳动物（包括人）中治疗血小板减少症的方法，其包括向所述哺乳动物施用有效量的选择的偶氮 - 吡唑衍生物。
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公开(公告)号：US07648971B2
公开(公告)日：2010-01-19
申请号：US12141422
申请日：2008-06-18
IPC分类号： A61K31/655 , A61K31/4152 , C07C245/10 , C07D231/46
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
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公开(公告)号：US07452874B2
公开(公告)日：2008-11-18
申请号：US11650838
申请日：2007-01-08
IPC分类号： C07D231/46 , A61K31/4152 , A61K31/655
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
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公开(公告)号：US07790704B2
公开(公告)日：2010-09-07
申请号：US12141397
申请日：2008-06-18
IPC分类号： A61K31/655 , A61P7/00 , C07D231/38
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
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公开(公告)号：US07439342B2
公开(公告)日：2008-10-21
申请号：US11650688
申请日：2007-01-08
申请人： Kevin J. Duffy , Juan I. Luengo
发明人： Kevin J. Duffy , Juan I. Luengo
IPC分类号： C07C245/10 , A61K31/655 , C07D231/46 , A61K31/4152
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
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公开(公告)号：US07335649B2
公开(公告)日：2008-02-26
申请号：US11558071
申请日：2006-11-09
IPC分类号： C07D231/46 , C07D401/12 , C07D403/12 , A61K31/4152
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
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公开(公告)号：US20130078213A1
公开(公告)日：2013-03-28
申请号：US13593739
申请日：2012-08-24
申请人： Kevin J. Duffy , Connie Erickson-Miller , Daniel F. Eppley , Julian Jenkins , Juan I. Luengo , Nannan Liu , Alan T. Price , Antony N. Shaw , Sophie Visonneau , Kenneth Wiggall
发明人： Kevin J. Duffy , Connie Erickson-Miller , Daniel F. Eppley , Julian Jenkins , Juan I. Luengo , Nannan Liu , Alan T. Price , Antony N. Shaw , Sophie Visonneau , Kenneth Wiggall
IPC分类号： C07D403/12 , A61K45/06 , A61K31/4155 , C07D231/46 , A61K31/415
CPC分类号： C07D231/46 , A61K31/415 , A61K31/4155 , A61K31/655 , A61K45/06 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
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公开(公告)号：US07674887B2
公开(公告)日：2010-03-09
申请号：US12141379
申请日：2008-06-18
IPC分类号： C07D231/46 , C07C215/76
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
摘要翻译： 发明的是非肽TPO模拟物。 还发明了用于制备本发明化合物的新方法和中间体。 还发明了一种在有需要的哺乳动物（包括人）中治疗血小板减少症的方法，其包括向所述哺乳动物施用有效量的选择的羟基-1-偶氮苯衍生物。
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公开(公告)号：US20090176973A1
公开(公告)日：2009-07-09
申请号：US12141379
申请日：2008-06-18
申请人： Kevin J. Duffy , Connie Erickson-Miller , Daniel F. Eppley , Julian Jenkins , Juan I. Luengo , Nannan Liu , Alan T. Price , Antony N. Shaw , Sophie Visonneau , Kenneth Wiggall
发明人： Kevin J. Duffy , Connie Erickson-Miller , Daniel F. Eppley , Julian Jenkins , Juan I. Luengo , Nannan Liu , Alan T. Price , Antony N. Shaw , Sophie Visonneau , Kenneth Wiggall
IPC分类号： C09B27/00 , C07C59/42 , C07D231/38
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
摘要翻译： 发明的是非肽TPO模拟物。 还发明了用于制备本发明化合物的新方法和中间体。 还发明了一种在有需要的哺乳动物（包括人）中治疗血小板减少症的方法，其包括向所述哺乳动物施用有效量的选择的羟基-1-偶氮苯衍生物。
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