公开(公告)号：US20110053885A1

公开(公告)日：2011-03-03

申请号：US12448064

申请日：2007-12-06

申请人： Kenji Miyamoto ,  Keiji Yoshioka ,  Katsuya Takahashi

发明人： Kenji Miyamoto ,  Keiji Yoshioka ,  Katsuya Takahashi

IPC分类号： A61K31/715 ,  A61P19/02

CPC分类号： A61K31/728 ,  A61K9/0019 ,  A61K9/06 ,  A61K31/738 ,  A61K47/02 ,  C08B37/0072

摘要： The present invention relates to an injection solution for intra-articular administration for treating arthritic disorders comprising a cross-linked hyaluronic acid derivative wherein part of functional groups of a hyaluronic acid are cross-linked with a cross-linking group to the extent of 0.6 to 15% of cross-linking extent as an active ingredient in an amount having a long-lasting analgesic effect and a pharmaceutically acceptable carrier, and an analgesic composition for suppressing a cartilage degeneration caused by arthritic disorders or a composition for suppressing a cartilage degeneration or an inflammation of synovium caused by arthritic disorders each comprising the cross-linked hyaluronic acid derivative and a pharmaceutically acceptable carrier.

摘要翻译： 本发明涉及用于治疗关节炎疾病的关节内给药的注射液，其包含交联的透明质酸衍生物，其中透明质酸的官能团的一部分与交联基团交联至0.6〜 具有持久镇痛效果的量的作为活性成分的交联程度的15％和药学上可接受的载体，以及用于抑制由关节炎病症引起的软骨退化的镇痛组合物或用于抑制软骨退化的组合物或 由关节炎病症引起的滑膜的炎症各自包含交联的透明质酸衍生物和药学上可接受的载体。

公开(公告)号：US08889652B2

公开(公告)日：2014-11-18

申请号：US12448064

申请日：2007-12-06

申请人： Kenji Miyamoto ,  Keiji Yoshioka ,  Katsuya Takahashi

发明人： Kenji Miyamoto ,  Keiji Yoshioka ,  Katsuya Takahashi

IPC分类号： A61K31/728 ,  A61K31/738 ,  A61P19/02

CPC分类号： A61K31/728 ,  A61K9/0019 ,  A61K9/06 ,  A61K31/738 ,  A61K47/02 ,  C08B37/0072

摘要： The present invention relates to an injection solution for intra-articular administration for treating arthritic disorders comprising a cross-linked hyaluronic acid derivative wherein part of functional groups of a hyaluronic acid are cross-linked with a cross-linking group to the extent of 0.6 to 15% of cross-linking extent as an active ingredient in an amount having a long-lasting analgesic effect and a pharmaceutically acceptable carrier, and an analgesic composition for suppressing a cartilage degeneration caused by arthritic disorders or a composition for suppressing a cartilage degeneration or an inflammation of synovium caused by arthritic disorders each comprising the cross-linked hyaluronic acid derivative and a pharmaceutically acceptable carrier.

摘要翻译： 本发明涉及用于治疗关节炎疾病的关节内给药的注射液，其包含交联的透明质酸衍生物，其中透明质酸的官能团的一部分与交联基团交联至0.6〜 具有持久镇痛效果的量的作为活性成分的交联程度的15％和药学上可接受的载体，以及用于抑制由关节炎病症引起的软骨退化的镇痛组合物或用于抑制软骨退化的组合物或 由关节炎病症引起的滑膜的炎症各自包含交联的透明质酸衍生物和药学上可接受的载体。

公开(公告)号：US20080221062A1

公开(公告)日：2008-09-11

申请号：US10585417

申请日：2005-01-07

申请人： Kenji Miyamoto ,  Yousuke Yasuda ,  Keiji Yoshioka

发明人： Kenji Miyamoto ,  Yousuke Yasuda ,  Keiji Yoshioka

IPC分类号： A61K31/726 ,  A61P19/02

CPC分类号： A61K31/196 ,  A61K31/192 ,  A61K31/405 ,  A61K31/5415 ,  A61K31/60 ,  A61K31/728 ,  A61K47/55 ,  A61K47/61

摘要： A hyaluronic acid derivative in which an anti-inflammatory drug is bound to hyaluronic acid through a covalent bond via a spacer having a biodegradable region, and a production process thereof.

摘要翻译： 一种透明质酸衍生物及其制备方法，其中抗炎药物通过共价键通过具有可生物降解区域的间隔物与透明质酸结合。

公开(公告)号：US07879817B2

公开(公告)日：2011-02-01

申请号：US10585417

申请日：2005-01-07

申请人： Kenji Miyamoto ,  Yousuke Yasuda ,  Keiji Yoshioka

发明人： Kenji Miyamoto ,  Yousuke Yasuda ,  Keiji Yoshioka

IPC分类号： A01N43/04 ,  A61K31/715 ,  A61K31/70 ,  A61P29/00

CPC分类号： A61K31/196 ,  A61K31/192 ,  A61K31/405 ,  A61K31/5415 ,  A61K31/60 ,  A61K31/728 ,  A61K47/55 ,  A61K47/61

摘要： A hyaluronic acid derivative in which an anti-inflammatory drug is bound to hyaluronic acid through a covalent bond via a spacer having a biodegradable region, and a production process thereof.

摘要翻译： 一种透明质酸衍生物及其制备方法，其中抗炎药物通过共价键通过具有可生物降解区域的间隔物与透明质酸结合。

公开(公告)号：US20080306022A1

公开(公告)日：2008-12-11

申请号：US12083189

申请日：2006-10-12

申请人： Kenji Miyamoto ,  Katsuya Takahashi ,  Yuuji Shimojima

发明人： Kenji Miyamoto ,  Katsuya Takahashi ,  Yuuji Shimojima

IPC分类号： A61K31/728 ,  C07H5/06 ,  A61P27/02

CPC分类号： A61K31/7008 ,  A61K9/0034 ,  A61K9/0048 ,  A61K9/006 ,  A61K31/726 ,  A61K31/728 ,  A61K47/61 ,  A61K49/0043 ,  A61K49/0054

摘要： An agent for applying to mucosa capable of persistently exerting a therapeutic effect on disorders such as inflammation and lesions in the mucosa even by a lower frequency of administration because the agent can stay at a diseased site for a long period of time by exhibiting a high staying property in a mucosal epithelial layer is provided, said agent for application to mucosa containing glycosaminoglycan (GAG) into which a hydrophobic group is introduced via a binding chain, as an active ingredient.

摘要翻译： 一种适用于粘膜的药剂，即使是较低的给药频率也能够持续地对诸如炎症和粘膜中的病变的疾病施加治疗效果，因为该药剂可以通过显示高停留时间长时间地停留在患病部位 提供粘膜上皮层中的特性，所述用于施用于通过结合链引入疏水基团的含有糖胺聚糖（GAG）的粘膜作为活性成分的药剂。

公开(公告)号：US20150196574A1

公开(公告)日：2015-07-16

申请号：US14600558

申请日：2015-01-20

申请人： Kenji Miyamoto ,  Katsuya Takahashi ,  Yuuji Shimojima

发明人： Kenji Miyamoto ,  Katsuya Takahashi ,  Yuuji Shimojima

IPC分类号： A61K31/7008

CPC分类号： A61K31/7008 ,  A61K9/0034 ,  A61K9/0048 ,  A61K9/006 ,  A61K31/726 ,  A61K31/728 ,  A61K47/61 ,  A61K49/0043 ,  A61K49/0054

摘要： An agent for applying to mucosa capable of persistently exerting a therapeutic effect on disorders such as inflammation and lesions in the mucosa even by a lower frequency of administration because the agent can stay at a diseased site for a long period of time by exhibiting a high staying properly in a mucosal epithelial layer is provided, said agent for application to mucosa containing glycosaminoglycan (GAG) into which a hydrophobic group is introduced via a binding chain, as an active ingredient.

摘要翻译： 一种适用于粘膜的药剂，即使是较低的给药频率也能够持续地对诸如炎症和粘膜中的病变的疾病施加治疗效果，因为该药剂可以通过显示高停留时间长时间地停留在患病部位 适当地在粘膜上皮层中适当地施用所述用于通过结合链引入疏水基团的含有糖胺聚糖（GAG）的粘膜作为活性成分。

公开(公告)号：US08507825B2

公开(公告)日：2013-08-13

申请号：US13248141

申请日：2011-09-29

申请人： Kenji Miyamoto ,  Shigeyuki Nakagawa

发明人： Kenji Miyamoto ,  Shigeyuki Nakagawa

IPC分类号： B23K11/11

CPC分类号： B23K11/115 ,  B23K11/20 ,  B23K2103/20 ,  Y10T428/12028 ,  Y10T428/12389 ,  Y10T428/24942

摘要： Disclosed is a bonding method for dissimilar materials made from metals and its resulting structures. The materials to be bonded are formed by layering three or more sheets such that a dissimilar material interface and a same material interface are formed. A first current is conducted between a three-sheet layered plate material wherein an aluminum alloy plate, a zinc plated steel plate and a bare steel plate, for example, are layered in order. A nugget is formed in an interface between the zinc plated steel plate and the bare steel plate, which are the same materials. Then, a second current greater than the first current is conducted, and a nugget is formed in an interface between the aluminum alloy plate and the zinc plated steel plate.

摘要翻译： 公开了一种用金属制成的不同材料及其结构的接合方法。 要结合的材料通过层叠三个或更多个片材形成，使得形成不同材料界面和相同的材料界面。 第一电流在例如铝合金板，镀锌钢板和裸钢板之间的三层叠层板材之间进行。 在镀锌钢板和裸钢板之间的界面上形成熔核，这是相同的材料。 然后，进行大于第一电流的第二电流，并且在铝合金板和镀锌钢板之间的界面中形成熔核。

公开(公告)号：US08058584B2

公开(公告)日：2011-11-15

申请号：US12049758

申请日：2008-03-17

申请人： Kenji Miyamoto ,  Shigeyuki Nakagawa

发明人： Kenji Miyamoto ,  Shigeyuki Nakagawa

IPC分类号： B23K11/16

CPC分类号： B23K11/115 ,  B23K11/20 ,  B23K2103/20 ,  Y10T428/12028 ,  Y10T428/12389 ,  Y10T428/24942

摘要： Disclosed is a bonding method for dissimilar materials made from metals and its resulting structures. The materials to be bonded are formed by layering three or more sheets such that a dissimilar material interface and a same material interface are formed. A first current is conducted between a three-sheet layered plate material wherein an aluminum alloy plate, a zinc plated steel plate and a bare steel plate, for example, are layered in order. A nugget is formed in an interface between the zinc plated steel plate and the bare steel plate, which are the same materials. Then, a second current greater than the first current is conducted, and a nugget is formed in an interface between the aluminum alloy plate and the zinc plated steel plate.

摘要翻译： 公开了一种用金属制成的不同材料及其结构的接合方法。 要结合的材料通过层叠三个或更多个片材形成，使得形成不同材料界面和相同的材料界面。 第一电流在例如铝合金板，镀锌钢板和裸钢板之间的三层叠层板材之间进行。 在镀锌钢板和裸钢板之间的界面上形成熔核，这是相同的材料。 然后，进行大于第一电流的第二电流，并且在铝合金板和镀锌钢板之间的界面中形成熔核。

公开(公告)号：US07984840B2

公开(公告)日：2011-07-26

申请号：US12944417

申请日：2010-11-11

申请人： Kojiro Kobayashi ,  Akio Hirose ,  Shigeyuki Nakagawa ,  Kenji Miyamoto ,  Minoru Kasukawa ,  Masayuki Inoue ,  Tetsuji Morita

发明人： Kojiro Kobayashi ,  Akio Hirose ,  Shigeyuki Nakagawa ,  Kenji Miyamoto ,  Minoru Kasukawa ,  Masayuki Inoue ,  Tetsuji Morita

IPC分类号： B23K1/00 ,  B23K1/002 ,  B23K1/008

CPC分类号： B23K11/20 ,  B23K11/166 ,  B23K20/2275 ,  B23K26/211 ,  B23K26/32 ,  B23K26/323 ,  B23K2101/34 ,  B23K2103/08 ,  B23K2103/20 ,  B23K2103/50 ,  Y10T29/49885

摘要： According to a metal joining method of the present invention, first and second dissimilar metals are joined together by interposing between the first and second metal materials a third metal material dissimilar to the first and second metal materials and causing eutectic melting at least either at an interface between the first and third metal materials or at an interface between the second and third metal materials.

公开(公告)号：US07935908B2

公开(公告)日：2011-05-03

申请号：US11633629

申请日：2006-12-05

申请人： Shigeyuki Nakagawa ,  Minoru Kasukawa ,  Kenji Miyamoto ,  Masayuki Inoue

发明人： Shigeyuki Nakagawa ,  Minoru Kasukawa ,  Kenji Miyamoto ,  Masayuki Inoue

IPC分类号： B23K37/00 ,  B23K31/02

CPC分类号： B23K15/0093 ,  B23K26/0093 ,  B23K26/037 ,  B23K26/211 ,  B23K26/244 ,  B23K33/00 ,  B23K2101/006 ,  B23K2101/34 ,  B23K2103/08 ,  B23K2103/20 ,  F16B5/04 ,  Y10T428/12493 ,  Y10T428/12799

摘要： A method of joining dissimilar materials of the present invention has a step of lapping a high melting point material on a low melting point material with a third material interposed therebetween. The third material is different from the high and low melting point materials. Further, the method has a step of irradiating an energy beam onto the high melting point material and a step of pressing the high and low melting point materials to cause eutectic melting between at least one of the high and low melting point materials and the third material and to join the high and low melting point materials in the form of a line.

摘要翻译： 本发明的不同材料的接合方法具有将第3材料插入其中的低熔点材料上研磨高熔点材料的工序。 第三种材料与高低熔点材料不同。 此外，该方法具有将能量束照射到高熔点材料上的步骤，以及对高熔点材料和低熔点材料进行挤压以在高熔点材料和低熔点材料中的至少一种和第三材料之间产生共晶熔化的步骤 并以一条线的形式加入高低熔点材料。