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    Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of macrophage colony stimulating factor receptor
    1.
    发明授权
    Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of macrophage colony stimulating factor receptor 失效
    喹啉衍生物和喹唑啉衍生物抑制巨噬细胞集落刺激因子受体的自磷酸化

    公开(公告)号：US07598258B2

    公开(公告)日：2009-10-06

    申请号：US10510961

    申请日：2003-05-01

    申请人： Kazuo Kubo ,  Hiroaki Ohno ,  Toshiyuki Isoe ,  Tuyoshi Nishitoba

    发明人： Kazuo Kubo ,  Hiroaki Ohno ,  Toshiyuki Isoe ,  Tuyoshi Nishitoba

    IPC分类号： C07D215/38 ,  A61K31/44

    CPC分类号： C07D215/233 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/5377 ,  C07D417/12

    摘要： An objective of the present invention is to provide compounds which have inhibitory activity against autophosphorylation of macrophage colony-stimulating factor receptors. The compounds of the present invention are represented by formula (I) and salt and solvate thereof: wherein X represents CH or N; Z represents O or S; R1, R2, and R3 represent H, optionally substituted alkoxy or the like; R4 represents H; R5, R6, R7, and R8 represent H, halogen, alkyl, alkoxy, trifluoromethyl or the like; R9 and R10 represent H, alkyl or the like; and any one of R11 and R12 represents H with the other representing alkyl and R13 represents an optionally substituted carbocyclic or heterocyclic ring or the like, or R11 represents H and R12 and R13 combine together to form a bicyclic carbocyclic ring.

    摘要翻译： 本发明的目的是提供对巨噬细胞集落刺激因子受体的自磷酸化具有抑制活性的化合物。 本发明的化合物由式（I）表示，其盐和溶剂化物：其中X表示CH或N; Z表示O或S; R1，R2和R3表示H，任选取代的烷氧基等; R4表示H; R5，R6，R7和R8表示H，卤素，烷基，烷氧基，三氟甲基等; R9和R10表示H，烷基等; R 11和R 12中的任一个表示H，另一个表示烷基，R 13表示任选取代的碳环或杂环等，或R 11表示H，R 12和R 13结合在一起形成双环碳环。

    Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of macrophage colony stimulating factor receptor
    2.
    发明申请
    Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of macrophage colony stimulating factor receptor 失效
    喹啉衍生物和喹唑啉衍生物抑制巨噬细胞集落刺激因子受体的自磷酸化

    公开(公告)号：US20060235033A1

    公开(公告)日：2006-10-19

    申请号：US10510961

    申请日：2003-05-01

    申请人： Kazuo Kubo ,  Hiroaki Ohno ,  Toshiyuki Isoe ,  Tsuyoshi Nishitoba

    发明人： Kazuo Kubo ,  Hiroaki Ohno ,  Toshiyuki Isoe ,  Tsuyoshi Nishitoba

    IPC分类号： A61K31/517 ,  A61K31/4704 ,  C07D239/88

    CPC分类号： C07D215/233 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/5377 ,  C07D417/12

    摘要： An objective of the present invention is to provide compounds which have inhibitory activity against autophosphorylation of macrophage colony-stimulating factor receptors. The compounds of the present invention are represented by formula (I) and salt and solvate thereof: wherein X represents CH or N; Z represents O or S; R1, R2, and R3 represent H, optionally substituted alkoxy or the like; R4 represents H; R5, R6, R7, and R8 represent H, halogen, alkyl, alkoxy, trifluoromethyl or the like; R9 and R10 represent H, alkyl or the like; and any one of R11 and R12 represents H with the other representing alkyl and R13 represents an optionally substituted carbocyclic or heterocyclic ring or the like, or R11 represents H and R12 and R13 combine together to form a bicyclic carbocyclic ring.

    摘要翻译： 本发明的目的是提供对巨噬细胞集落刺激因子受体的自磷酸化具有抑制活性的化合物。 本发明的化合物由式（I）表示，其盐和溶剂化物：其中X表示CH或N; Z表示O或S; R 1，R 2，R 3和R 3代表H，任选取代的烷氧基等; R 4表示H; R 5，R 6，R 7和R 8表示H，卤素，烷基，烷氧基，三氟甲基 或类似物; R 9和R 10代表H，烷基等; 并且R 11和R 12中的任何一个代表H，另一个代表烷基，R 13表示任选取代的碳环或杂环或 或者R 11表示H并且R 12和R 13结合在一起以形成双环碳环。

    Quinoline derivatives and quinazoline derivatives
    5.
    发明申请
    Quinoline derivatives and quinazoline derivatives 审中-公开
    喹啉衍生物和喹唑啉衍生物

    公开(公告)号：US20070027318A1

    公开(公告)日：2007-02-01

    申请号：US11526739

    申请日：2006-09-26

    申请人： Kazuo Kubo ,  Yasunari Fujiwara ,  Toshiyuki Isoe

    发明人： Kazuo Kubo ,  Yasunari Fujiwara ,  Toshiyuki Isoe

    IPC分类号： C07D413/02 ,  C07D403/02 ,  C07D401/02

    CPC分类号： C07D215/233 ,  C07D231/12 ,  C07D233/56 ,  C07D239/88 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12

    摘要： An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions comprising said compounds: wherein X and Z each independently represent CH or N; R1 to R3 represent H, substituted alkoxy, unsubstituted alkoxy or the like; R4 represents H; R5 to R8 represent H, halogen, alkyl, alkoxy, alkylthio, nitro, or amino, provided that R5 to R8 do not simultaneously represent H; R9 and R10 represent H, alkyl, or alkylcarbonyl; and R11 represents alkyl, alkenyl, alkynyl, or aralkyl.

    摘要翻译： 本发明的目的是提供具有抗肿瘤活性并且不改变细胞毒性的化合物。 公开了由式（I）表示的化合物及其药学上可接受的盐和溶剂合物和包含所述化合物的药物组合物：其中X和Z各自独立地表示CH或N; R 1至R 3代表H，取代的烷氧基，未取代的烷氧基等; R 4表示H; R 5至R 8表示H，卤素，烷基，烷氧基，烷硫基，硝基或氨基，条件是R 5至R“ > 8 不同时代表H; R 9和R 10代表H，烷基或烷基羰基; R 11表示烷基，烯基，炔基或芳烷基。

    Quinoline derivatives and quinazoline derivatives
    7.
    发明授权
    Quinoline derivatives and quinazoline derivatives 失效
    喹啉衍生物和喹唑啉衍生物

    公开(公告)号：US06797823B1

    公开(公告)日：2004-09-28

    申请号：US09889858

    申请日：2001-07-23

    申请人： Kazuo Kubo ,  Yasunari Fujiwara ,  Toshiyuki Isoe

    发明人： Kazuo Kubo ,  Yasunari Fujiwara ,  Toshiyuki Isoe

    IPC分类号： C07D23988

    CPC分类号： C07D215/233 ,  C07D231/12 ,  C07D233/56 ,  C07D239/88 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12

    摘要： An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions comprising said compounds: wherein X and Z each independently represent CH or N; R1 to R3 represent H, substituted alkoxy, unsubstituted alkoxy or the like; R4 represents H; R5 to R8 represent H, halogen, alkyl, alkoxy, alkylthio, nitro, or amino, provided that R5 to R8 do not simultaneously represent H; R9 and R10 represent H, alkyl, or alkylcarbonyl; and R11 represents alkyl, alkenyl, alkynyl, or aralkyl.

    摘要翻译： 本发明的目的是提供具有抗肿瘤活性并且不改变细胞毒性的化合物。 公开了由式（I）表示的化合物及其药学上可接受的盐和溶剂合物和包含所述化合物的药物组合物：其中X和Z各自独立地表示CH或N; R 1至R 3代表H，取代的烷氧基，未被取代的烷氧基等; R 4表示H; R 5至R 8表示H，卤素，烷基，烷氧基，烷硫基，硝基或氨基，条件是R 5至R 8不同时表示H; R 9和R 10代表H，烷基或烷基羰基; R 11表示烷基，烯基，炔基或芳烷基。

    Optical network system and WDM apparatus
    8.
    发明授权
    Optical network system and WDM apparatus 有权
    光网络系统和WDM设备

    公开(公告)号：US08731398B2

    公开(公告)日：2014-05-20

    申请号：US13421327

    申请日：2012-03-15

    申请人： Yuji Akiyama ,  Kazuo Kubo ,  Sota Yoshida

    发明人： Yuji Akiyama ,  Kazuo Kubo ,  Sota Yoshida

    IPC分类号： H04B10/00

    CPC分类号： H04J3/14 ,  H04J3/1611 ,  H04J2203/006

    摘要： An optical network system that performs transmission of N:1 protection includes a node that includes transmission-side operating muxponders that multiplex client signals for every M-channel signal bundle and convert multiplexed signals into optical signals having different wavelengths, transmission-side optical couplers that branch the client signals into two channels of operating and redundant, transmission-side optical switches each selecting one channel from redundant signals as a redundant client signal, and a transmission-side redundant muxponder that performs a predetermined transmission-side process according to an accommodation mode set on the redundant client signal and then multiplexes the redundant client signals, converts the multiplexed signal into an optical signal having a wavelength different from that of the operating signal, thereby making the accommodation mode settable for each channel in an independent manner.

    摘要翻译： 执行N：1保护的传输的光网络系统包括：节点，其包括传输侧操作的多路复用应答器，其将每个M信道信号束的客户信号复用并将多路复用信号转换成具有不同波长的光信号;传输侧光耦合器， 将客户端信号分为两个通道的操作和冗余的发送侧光交换机，每个从冗余信号中选择一个信道作为冗余客户端信号;以及发送侧冗余复用应答器，其根据调节模式执行预定的发送侧处理 设置在冗余客户端信号上，然后复用冗余客户端信号，将多路复用信号转换成具有与操作信号波长不同的波长的光信号，从而以独立的方式使每个信道的调节模式可设置。

    GAS METER AND GAS SAFETY SYSTEM
    10.
    发明申请
    GAS METER AND GAS SAFETY SYSTEM 有权
    气体表和气体安全系统

    公开(公告)号：US20110004353A1

    公开(公告)日：2011-01-06

    申请号：US12921340

    申请日：2009-02-24

    申请人： Mitsuo Yokohata ,  Hirozumi Nakamura ,  Tadanori Shirasawa ,  Kazuo Kubo ,  Mitsuo Namba ,  Hisashi Saito

    发明人： Mitsuo Yokohata ,  Hirozumi Nakamura ,  Tadanori Shirasawa ,  Kazuo Kubo ,  Mitsuo Namba ,  Hisashi Saito

    IPC分类号： G05D7/06

    CPC分类号： G01F15/068 ,  F23N5/242 ,  F23N2025/04 ,  F23N2031/14 ,  G08B21/16 ,  Y10T137/7062

    摘要： Setting safety function, as appropriate, according to a user environment is enabled, thereby enhancing safety function. According to selection information from a safety function selection unit 120, a function setting unit 116 sets arbitrary function among a plurality of functions as safety function pertaining to usage of a gas. When operating conditions for safety function are fulfilled, a monitoring unit 112 detects malfunction, which would arise during usage of a gas, and outputs a safety signal to a control unit 114 in accordance with the set safety function. In accordance with a safety signal from the monitoring unit 112, the control unit 114 cuts off a gas supply when an event fulfilling operating conditions for the set function has arisen. When an event fulfilling operating conditions for an unset function has arisen, a communication unit 124 reports occurrence of malfunction pertaining to unset function to the monitoring center 200.

    摘要翻译： 可根据用户环境设置安全功能，从而提高安全性。 功能设定单元116根据来自安全功能选择单元120的选择信息，将多个功能中的任意功能设置为与气体的使用有关的安全功能。 当满足安全功能的操作条件时，监视单元112检测在使用气体期间将发生的故障，并且根据所设置的安全功能将安全信号输出到控制单元114。 根据来自监视单元112的安全信号，当产生满足设定功能的操作条件的事件时，控制单元114切断气体供应。 当产生满足未设定功能的操作条件的事件时，通信单元124向监视中心200报告与未设置功能相关的故障的发生。