公开(公告)号：US20120276644A1

公开(公告)日：2012-11-01

申请号：US13504890

申请日：2010-10-29

申请人： Hideo Utsumi ,  Fuminori Hyodo ,  Kazuhiro Ichikawa

发明人： Hideo Utsumi ,  Fuminori Hyodo ,  Kazuhiro Ichikawa

IPC分类号： A61B5/055 ,  G01N24/08

CPC分类号： A61K49/20 ,  G01R33/48 ,  G01R33/485 ,  G01R33/5601 ,  G01R33/60 ,  G01R33/62 ,  Y10T436/141111 ,  Y10T436/142222 ,  Y10T436/200833 ,  Y10T436/24

摘要： Provided is a method for the real-time visualization of an endogenous biomolecule to clarify the mechanisms of various diseases and enable diagnosis and treatment of these diseases. Specifically provided is a novel method for visualizing an endogenous biomolecule by using a magnetic resonance method (including Overhauser MRI and the electron spin resonance method). The aforesaid visualization method, whereby an endogenous biomolecule is visualized on a real-time basis, comprises: a step for treating a living organism to be examined by a magnetic resonance method and thus acquiring data of the endogenous biomolecule; a step for processing the data of the endogenous biomolecule thus obtained to give imaging data; and a step for displaying the imaging data thus obtained.

摘要翻译： 提供了一种内源性生物分子的实时可视化方法，以澄清各种疾病的机制，并能够诊断和治疗这些疾病。 具体提供的是通过使用磁共振法（包括Overhauser MRI和电子自旋共振法）来观察内源性生物分子的新方法。 上述可视化方法，其中内生生物分子在实时的基础上可视化，包括：通过磁共振方法处理待检查的活生物体，从而获取内源性生物分子的数据的步骤; 用于处理由此获得的内源性生物分子的数据以提供成像数据的步骤; 以及用于显示由此获得的成像数据的步骤。

公开(公告)号：US08722420B2

公开(公告)日：2014-05-13

申请号：US13504890

申请日：2010-10-29

申请人： Hideo Utsumi ,  Fuminori Hyodo ,  Kazuhiro Ichikawa

发明人： Hideo Utsumi ,  Fuminori Hyodo ,  Kazuhiro Ichikawa

IPC分类号： G01N24/00

CPC分类号： A61K49/20 ,  G01R33/48 ,  G01R33/485 ,  G01R33/5601 ,  G01R33/60 ,  G01R33/62 ,  Y10T436/141111 ,  Y10T436/142222 ,  Y10T436/200833 ,  Y10T436/24

摘要： Provided is a method for the real-time visualization of an endogenous biomolecule to clarify the mechanisms of various diseases and enable diagnosis and treatment of these diseases. Specifically provided is a novel method for visualizing an endogenous biomolecule by using a magnetic resonance method (including Overhauser MRI and the electron spin resonance method). The aforesaid visualization method, whereby an endogenous biomolecule is visualized on a real-time basis, comprises: a step for treating a living organism to be examined by a magnetic resonance method and thus acquiring data of the endogenous biomolecule; a step for processing the data of the endogenous biomolecule thus obtained to give imaging data; and a step for displaying the imaging data thus obtained.

摘要翻译： 提供了一种内源性生物分子的实时可视化方法，以澄清各种疾病的机制，并能够诊断和治疗这些疾病。 具体提供的是通过使用磁共振法（包括Overhauser MRI和电子自旋共振法）来观察内源性生物分子的新方法。 上述可视化方法，其中内生生物分子在实时的基础上可视化，包括：通过磁共振方法处理待检查的活生物体，从而获取内源性生物分子的数据的步骤; 用于处理由此获得的内源性生物分子的数据以提供成像数据的步骤; 以及用于显示由此获得的成像数据的步骤。

公开(公告)号：US20110112395A1

公开(公告)日：2011-05-12

申请号：US13002920

申请日：2009-07-07

申请人： Kazuhiro Ichikawa ,  Hideo Utsumi

发明人： Kazuhiro Ichikawa ,  Hideo Utsumi

IPC分类号： A61B5/055

CPC分类号： A61B5/0555 ,  A61B5/0035 ,  A61B2503/40 ,  G01N24/10 ,  G01R33/3806 ,  G01R33/381 ,  G01R33/3815 ,  G01R33/383 ,  G01R33/481 ,  G01R33/4812 ,  G01R33/56375 ,  G01R33/56383 ,  G01R33/60 ,  G01R33/62

摘要： A measurement device and measurement method make it possible to eliminate the load generated by stopping on a measurement subject that is moved among multiple magnetic field generating devices. The measurement device includes a first external magnetic field generating device that generates a magnetic field of a set size, a second external magnetic field generating device that generates a magnetic field of a size that differs from that of the magnetic field of the first external magnetic field generating device, a rotating table that causes the subject of measurement to pass in sequence through the magnetic fields of the first and second external magnetic field generating devices by causing the subject of measurement to move rotationally, and an OMRI measurement processing part and MRI measurement processing part that measures images such as functional images or structural images of the subject of measurement while it is being moved rotationally by the rotating table.

摘要翻译： 测量装置和测量方法可以消除由在多个磁场产生装置之间移动的测量对象停止而产生的负载。 测量装置包括产生一定尺寸的磁场的第一外部磁场产生装置，产生尺寸与第一外部磁场的磁场的磁场不同的磁场的第二外部磁场产生装置 生成装置，通过使测量对象旋转移动使得测量对象依次通过第一外部磁场产生装置和第二外部磁场产生装置的磁场的旋转台，以及OMRI测量处理部分和MRI测量处理 在通过旋转台被旋转移动的同时测量诸如测量对象的功能图像或结构图像的图像的部分。

公开(公告)号：US08532740B2

公开(公告)日：2013-09-10

申请号：US13002920

申请日：2009-07-07

申请人： Kazuhiro Ichikawa ,  Hideo Utsumi

发明人： Kazuhiro Ichikawa ,  Hideo Utsumi

IPC分类号： A61B5/05

CPC分类号： A61B5/0555 ,  A61B5/0035 ,  A61B2503/40 ,  G01N24/10 ,  G01R33/3806 ,  G01R33/381 ,  G01R33/3815 ,  G01R33/383 ,  G01R33/481 ,  G01R33/4812 ,  G01R33/56375 ,  G01R33/56383 ,  G01R33/60 ,  G01R33/62

摘要： A measurement device and measurement method make it possible to eliminate the load generated by stopping on a measurement subject that is moved among multiple magnetic field generating devices. The measurement device includes a first external magnetic field generating device that generates a magnetic field of a set size, a second external magnetic field generating device that generates a magnetic field of a size that differs from that of the magnetic field of the first external magnetic field generating device, a rotating table that causes the subject of measurement to pass in sequence through the magnetic fields of the first and second external magnetic field generating devices by causing the subject of measurement to move rotationally, and an OMRI measurement processing part and MRI measurement processing part that measures images such as functional images or structural images of the subject of measurement while it is being moved rotationally by the rotating table.

摘要翻译： 测量装置和测量方法可以消除由在多个磁场产生装置之间移动的测量对象停止而产生的负载。 测量装置包括产生一定尺寸的磁场的第一外部磁场产生装置，产生尺寸与第一外部磁场的磁场的磁场不同的磁场的第二外部磁场产生装置 生成装置，通过使测量对象旋转移动使得测量对象依次通过第一外部磁场产生装置和第二外部磁场产生装置的磁场的旋转台，以及OMRI测量处理部分和MRI测量处理 在通过旋转台旋转移动的同时测量诸如测量对象的功能图像或结构图像的图像的部分。

公开(公告)号：US20120068705A1

公开(公告)日：2012-03-22

申请号：US13258743

申请日：2010-03-25

申请人： Hideo Utsumi ,  Kazuhiro Ichikawa ,  Tetsuhiko Takahashi

发明人： Hideo Utsumi ,  Kazuhiro Ichikawa ,  Tetsuhiko Takahashi

IPC分类号： G01R33/56

CPC分类号： G01R33/4808 ,  A61B5/055 ,  A61B5/0555 ,  G01R33/3806 ,  G01R33/445 ,  G01R33/56383 ,  G01R33/56509 ,  G01R33/60

摘要： A measuring instrument and a measurement method which measures, using magnetic resonance, images such as a functional image, a morphologic image of an object to be measured eliminate the influences of the moving speed of the object to be measured during moving, thereby obtaining a precise measured image. The instrument comprises: the first and second external magnetic field generation devices which generate magnetic fields for exciting the magnetic resonance of a mouse (M) as a living body to be measured; a turntable which rotates and moves the mouse (M) as an object to be measured, thereby moving the mouse (M) in the magnetic fields of the first and second external magnetic field generation devices; an OMRI measurement processing unit and an MRI measurement processing unit which obtain measured image signals within the mouse (M) by phase encoding while applying a gradient magnetic field in the moving direction (y) of the mouse (M) without stopping during the movement by the turntable; and a measured signal correction unit which corrects the measured image signal (S (k., ky)), thereby obtaining a corrected image signal (S′ (k., ky)) wherein influence of movement in y-direction is corrected.

摘要翻译： 使用磁共振测量功能图像，待测量对象的形态图像的测量仪器和测量方法消除了移动期间被测量物体的移动速度的影响，从而获得精确的 测量图像。 仪器包括：第一和第二外部磁场产生装置，其产生用于激发作为要测量的活体的鼠标（M）的磁共振的磁场; 旋转并移动作为测量对象的鼠标（M）的转台，从而在第一和第二外部磁场产生装置的磁场中移动鼠标（M）; OMRI测量处理单元和MRI测量处理单元，其通过相位编码获得鼠标（M）内的测量图像信号，同时在移动期间不停止地在鼠标（M）的移动方向（y）上施加梯度磁场， 转盘; 以及校正测量图像信号（S（k，ky））的测量信号校正单元，从而获得校正了在y方向上的移动影响的校正图像信号（S'（k，ky））。

公开(公告)号：US08896311B2

公开(公告)日：2014-11-25

申请号：US13258743

申请日：2010-03-25

申请人： Hideo Utsumi ,  Kazuhiro Ichikawa ,  Tetsuhiko Takahashi

发明人： Hideo Utsumi ,  Kazuhiro Ichikawa ,  Tetsuhiko Takahashi

IPC分类号： G01V3/00 ,  A61B5/055 ,  G01R33/563 ,  G01R33/60 ,  G01R33/48 ,  G01R33/565 ,  G01R33/38 ,  G01R33/44

CPC分类号： G01R33/4808 ,  A61B5/055 ,  A61B5/0555 ,  G01R33/3806 ,  G01R33/445 ,  G01R33/56383 ,  G01R33/56509 ,  G01R33/60

摘要： A measuring instrument and a measurement method which measures, using magnetic resonance, images such as a functional image, a morphologic image of an object to be measured eliminate the influences of the moving speed of the object to be measured during moving, thereby obtaining a precise measured image. The instrument comprises: the first and second external magnetic field generation devices which generate magnetic fields for exciting the magnetic resonance of a mouse (M) as a living body to be measured; a turntable which rotates and moves the mouse (M) as an object to be measured, thereby moving the mouse (M) in the magnetic fields of the first and second external magnetic field generation devices; an OMRI measurement processing unit and an MRI measurement processing unit which obtain measured image signals within the mouse (M) by phase encoding while applying a gradient magnetic field in the moving direction (y) of the mouse (M) without stopping during the movement by the turntable; and a measured signal correction unit which corrects the measured image signal (S (k., ky)), thereby obtaining a corrected image signal (S′ (k., ky)) wherein influence of movement in y-direction is corrected.

摘要翻译： 使用磁共振测量功能图像，待测量对象的形态图像的测量仪器和测量方法消除了移动期间被测量物体的移动速度的影响，从而获得精确的 测量图像。 仪器包括：第一和第二外部磁场产生装置，其产生用于激发作为要测量的活体的鼠标（M）的磁共振的磁场; 旋转并移动作为测量对象的鼠标（M）的转台，从而在第一和第二外部磁场产生装置的磁场中移动鼠标（M）; OMRI测量处理单元和MRI测量处理单元，其通过相位编码获得鼠标（M）内的测量图像信号，同时在移动期间不停止地在鼠标（M）的移动方向（y）上施加梯度磁场， 转盘; 以及校正测量图像信号（S（k，ky））的测量信号校正单元，从而获得校正了在y方向上的移动影响的校正图像信号（S'（k，ky））。

公开(公告)号：US20100076190A1

公开(公告)日：2010-03-25

申请号：US12523341

申请日：2008-01-30

申请人： Hideo Utsumi ,  Kiyoshi Sakai ,  Kenichi Yamada

发明人： Hideo Utsumi ,  Kiyoshi Sakai ,  Kenichi Yamada

IPC分类号： C07D211/74 ,  C07D491/20 ,  C07D495/20 ,  C07D471/20 ,  C07D471/10

CPC分类号： C07D211/74 ,  A61K49/20 ,  C07D211/94 ,  C07D221/20 ,  C07D471/10 ,  C07D471/20 ,  C07D491/20 ,  C07D495/20

摘要： The problem to be solved by the present invention is to provide a highly-versatile method for producing a nitroxyl radical derivative, in which position-2 and position-6 in a TEMPO-based compound can be easily substituted, and further, a method for producing a nitroxyl radical derivative, in which a nitrogen nucleus is labeled with 15N. The above-described problem can be solved by reacting a triacetoneamine derivative with ketone or aldehyde in the presence of ammonium salt or a 15N-labeled compound thereof to obtain a 2,6-substituted-4-piperidone derivative.

摘要翻译： 本发明要解决的问题是提供一种用于制备硝酰自由基衍生物的高通用性方法，其中TEMPO基化合物中的位置2和位置-6可以容易地被取代，此外，还提供了一种用于 产生氮氧自由基衍生物，其中氮核用15N标记。 上述问题可以通过在铵盐或其15N标记的化合物存在下使三丙酮衍生物与酮或醛反应来获得2,6-取代-4-哌啶酮衍生物来解决。

公开(公告)号：US08513417B2

公开(公告)日：2013-08-20

申请号：US12523341

申请日：2008-01-30

申请人： Hideo Utsumi ,  Kiyoshi Sakai ,  Kenichi Yamada

发明人： Hideo Utsumi ,  Kiyoshi Sakai ,  Kenichi Yamada

IPC分类号： C07D221/20

CPC分类号： C07D211/74 ,  A61K49/20 ,  C07D211/94 ,  C07D221/20 ,  C07D471/10 ,  C07D471/20 ,  C07D491/20 ,  C07D495/20

摘要： The problem to be solved by the present invention is to provide a highly-versatile method for producing a nitroxyl radical derivative, in which position-2 and position-6 in a TEMPO-based compound can be easily substituted, and further, a method for producing a nitroxyl radical derivative, in which a nitrogen nucleus is labeled with 15N. The above-described problem can be solved by reacting a triacetoneamine derivative with ketone or aldehyde in the presence of ammonium salt or a 15N-labeled compound thereof to obtain a 2,6-substituted-4-piperidone derivative.

摘要翻译： 本发明要解决的问题是提供一种用于制备硝酰自由基衍生物的高通用性方法，其中TEMPO基化合物中的位置2和位置-6可以容易地被取代，此外，还提供了一种用于 产生氮氧自由基衍生物，其中氮核用15N标记。 上述问题可以通过在铵盐或其15N标记的化合物存在下使三丙酮衍生物与酮或醛反应来获得2,6-取代-4-哌啶酮衍生物来解决。

公开(公告)号：US06239145B1

公开(公告)日：2001-05-29

申请号：US09446122

申请日：1999-12-27

申请人： Hideo Utsumi ,  Hiroaki Sano ,  Masaichi Naruse ,  Takashi Igarashi ,  Tetsuo Oi

发明人： Hideo Utsumi ,  Hiroaki Sano ,  Masaichi Naruse ,  Takashi Igarashi ,  Tetsuo Oi

IPC分类号： A61K31445

CPC分类号： A61K49/20 ,  A61K49/0002 ,  C07D207/46 ,  C07D211/94

摘要： Nitroxyl compounds represented by general formula (I) which are usable in acquiring information about active oxygen or in vivo free radicals as biological images such as magnetic resonance images or magnetoencephalograms, wherein A represents hydrogen or —L—(CH2)n—OCOR (wherein L represents —COO— or -alkylene-COO—; and R represents C1-4 alkyl); R1, R2, R3, and R4 represent each C1-4 alkyl; and n is a number of from 1 to 4. Drugs and reagents containing the above compounds are usable in preventing, treating or diagnosing ischemic diseases, digestive diseases, cancer, cranial nervous diseases accompanied by nerve degeneration, inflammation, cataracts, or drug-induced organopathy.

摘要翻译： 可用于获取关于活性氧或体内自由基的信息的由通式（I）表示的硝基化合物作为生物学图像如磁共振图像或脑磁图，其中A表示氢或-L-（CH2）n-OCOR（其中 L表示-COO-或 - 亚烷基-COO-; R表示C1-4烷基）; R 1，R 2，R 3和R 4表示各个C 1-4烷基; 含有上述化合物的药物和试剂可用于预防，治疗或诊断缺血性疾病，消化系统疾病，癌症，伴有神经变性，炎症，白内障或药物诱发的颅神经疾病 有机病。