公开(公告)号：US20220213675A1

公开(公告)日：2022-07-07

申请号：US17608977

申请日：2020-05-14

Applicant: Karl-Josef Kramer ,  Werner Kramer

Inventor： Karl-Josef Kramer ,  Werner Kramer

IPC: E03D9/08 ,  A47K10/48 ,  H04N5/225 ,  H04N7/18

Abstract: A toilet device with inspection functions, highly controllable cleaning, drying, visual observation and reporting functions. Certain embodiments of such observation, inspection, cleaning and drying of the user's posterior and genitals are introduced in some detail, and so are the automatic self-cleaning and drying mechanisms, structures and methods of the observation and cleaning devices. This device allows the user to take full control of observing their bowel movement as well as controlling proper cleaning and drying afterwards. In addition, toilet device embodiments are presented which can be combined with the described observation and cleaning features and which support people lacking mobility, strength or coordination or having sensory impairments by executing certain bodily motions, such as bringing the user into a more or less crouching or rocking position in order to facilitate bowel movement. For all actuations, activation via voice, push button, touch screen or joystick control are all envisioned.

公开(公告)号：US20210310227A1

公开(公告)日：2021-10-07

申请号：US17264273

申请日：2019-07-31

Applicant: Karl-Josef KRAMER

Inventor： Werner Kramer ,  Karl-Josef Kramer

IPC: E03D9/08 ,  H04N5/232 ,  G06T7/00 ,  H04N5/225 ,  G03B17/56 ,  G02B27/00

Abstract: A toilet device with inspection functions, with highly controllable cleaning, drying and reporting functions is presented. Said device is geared towards users with impaired mobility and sensory functions, such as overweight people, people lacking strength or reach, as well as, and in particular, paraplegic and quadriplegic users with sensory impairments. This device allows the user to take full control of observing their bowel movement as well as controlling proper cleaning and drying afterwards, including optional post drying treatments such as using lotions in inflamed areas. Voice activation, push button, touch screen and joystick control allow for direct, flexible and reliable control of the implemented functions, despite a user's potential impairments. Logging and reporting to caretakers or doctors provides possibility for quick interaction and feedback, as well as tracking diet incompatibilities when coupled to or compared with a user's diet diary.

公开(公告)号：US07956085B2

公开(公告)日：2011-06-07

申请号：US12465911

申请日：2009-05-14

Applicant: Wendelin Frick ,  Heiner Glombik ,  Stefan Theis ,  Hubert Heuer ,  Hans-Ludwig Schaefer ,  Werner Kramer

Inventor： Wendelin Frick ,  Heiner Glombik ,  Stefan Theis ,  Hubert Heuer ,  Hans-Ludwig Schaefer ,  Werner Kramer

IPC: A61K31/38 ,  C07D409/08

CPC classification number: C07H5/06 ,  A61K31/38 ,  A61K31/7028 ,  A61K45/06 ,  C07D409/12 ,  C07H5/04 ,  C07H7/02 ,  C07H7/027 ,  C07H13/12 ,  C07H15/26 ,  A61K2300/00

Abstract: This invention relates to Novel 1,4-benzothiepine 1,1-dioxide derivatives substituted by benzyl radicals, method for their preparation, pharmaceuticals comprising these compounds, and the use thereof.

Abstract translation: 本发明涉及由苄基取代的新型1,4-苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途。

公开(公告)号：US20070197498A1

公开(公告)日：2007-08-23

申请号：US11690993

申请日：2007-03-26

Applicant: Gerhard JAEHNE ,  Wendelin Frick ,  Andreas Lindenschmidt ,  Stefanie Flohr ,  Hubert Heuer ,  Hans-Ludwig Schaefer ,  Werner Kramer ,  Eric Galia ,  Heiner Glombik

Inventor： Gerhard JAEHNE ,  Wendelin Frick ,  Andreas Lindenschmidt ,  Stefanie Flohr ,  Hubert Heuer ,  Hans-Ludwig Schaefer ,  Werner Kramer ,  Eric Galia ,  Heiner Glombik

IPC: A61K31/397 ,  C07D205/02

CPC classification number: C07C233/18 ,  C07D205/08

Abstract: Novel diphenylazetidinone, process for its preparation, medicaments comprising this compound and their use The invention relates to the compound of the formula 1 and to its physiologically acceptable salts. The compound is suitable, for example, as a hypolipidemic.

Abstract translation: 新型二苯基氮杂环丁酮，其制备方法，包含该化合物的药物及其用途本发明涉及式1的化合物及其生理上可接受的盐。 该化合物例如可用作降血脂药物。

公开(公告)号：US20070043017A1

公开(公告)日：2007-02-22

申请号：US11544718

申请日：2006-10-10

Applicant: Gerhard Jaehne ,  Wendelin Frick ,  Stefanie Flohr ,  Andreas Lindenschmidt ,  Heiner Glombik ,  Werner Kramer ,  Hubert Heuer ,  Hans-Ludwig Schaefer

Inventor： Gerhard Jaehne ,  Wendelin Frick ,  Stefanie Flohr ,  Andreas Lindenschmidt ,  Heiner Glombik ,  Werner Kramer ,  Hubert Heuer ,  Hans-Ludwig Schaefer

IPC: A61K31/397 ,  C07D205/02 ,  C07D403/02

CPC classification number: C07D403/12 ,  C07D205/08 ,  C07D453/02 ,  C07D487/08 ,  Y10S930/28

Abstract: One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.

公开(公告)号：US07179792B2

公开(公告)日：2007-02-20

申请号：US10699967

申请日：2003-11-03

Applicant: Heiner Glombik ,  Wendelin Frick ,  Hans-Ludwig Schaefer ,  Werner Kramer

Inventor： Heiner Glombik ,  Wendelin Frick ,  Hans-Ludwig Schaefer ,  Werner Kramer

IPC: A61K38/06 ,  A61K38/05 ,  A61K38/04 ,  C07K5/06 ,  C07K5/04

CPC classification number: A61K45/06 ,  A61K31/395 ,  A61K31/55 ,  A61K2300/00

Abstract: The present invention is directed to a 1,4-benzothiepine 1,1-dioxide compound of formula I in which the radicals have the meanings defined herein, or a pharmaceutically acceptable salt or physiologically functional derivative thereof, with at least one other active ingredient, or a pharmaceutically acceptable salt or physiologically functional derivative thereof. The invention is also directed to the use of the combination product, pharmaceutical composition comprising the combination product and method for preparing the pharmaceutical composition.

Abstract translation: 本发明涉及其中基团具有本文定义的含义，或其药学上可接受的盐或生理功能衍生物的式I的1,4-苯并硫代1,1-二氧化物化合物与至少一种其它活性成分， 或其药学上可接受的盐或生理功能衍生物。 本发明还涉及组合产品，包含组合产品和方法的药物组合物用于制备药物组合物的用途。

公开(公告)号：US06498156B2

公开(公告)日：2002-12-24

申请号：US10021028

申请日：2001-12-19

Applicant: Heiner Glombik ,  Werner Kramer ,  Stefanie Flohr ,  Wendelin Frick ,  Hubert Heuer ,  Gerhard Jaehne ,  Andreas Lindenschmidt ,  Hans-Ludwig Schaefer

Inventor： Heiner Glombik ,  Werner Kramer ,  Stefanie Flohr ,  Wendelin Frick ,  Hubert Heuer ,  Gerhard Jaehne ,  Andreas Lindenschmidt ,  Hans-Ludwig Schaefer

IPC: A61K31397

CPC classification number: C07D401/14 ,  C07D205/08 ,  C07D409/12

Abstract: Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.

Abstract translation: 其中R1，R2，R3，R4，R5和R6具有说明书中给出的含义的式I化合物及其生理上可接受的盐。 该化合物适合用作例如降血脂药。

公开(公告)号：US06180618B2

公开(公告)日：2001-01-30

申请号：US09408169

申请日：1999-09-29

Applicant: Siegfried Stengelin ,  Alfons Enhsen ,  Heiner Glombik ,  Werner Kramer ,  Eugen Falk

Inventor： Siegfried Stengelin ,  Alfons Enhsen ,  Heiner Glombik ,  Werner Kramer ,  Eugen Falk

IPC: A61K3158

CPC classification number: C07J7/00 ,  C07J9/00

Abstract: Compounds of formula (I) in which the radicals are as defined in the specification and claims, and physiologically tolerated and physiologically functional derivatives thereof and processes for their preparation are described. The compounds are suitable, for example, as hypolipidemic agents.

Abstract translation: 描述了其中基团如说明书和权利要求书中所定义的式（I）化合物及其生理学耐受性和生理功能性衍生物及其制备方法。 该化合物例如可用作降血脂药物。

公开(公告)号：US5512558A

公开(公告)日：1996-04-30

申请号：US238514

申请日：1994-05-05

Applicant: Alfons Enhsen ,  Heiner Glombik ,  Werner Kramer ,  Gunther Wess

Inventor： Alfons Enhsen ,  Heiner Glombik ,  Werner Kramer ,  Gunther Wess

IPC: A61K31/575 ,  A61P3/06 ,  A61P9/00 ,  C07J3/00 ,  C07J7/00 ,  C07J9/00 ,  C07J31/00 ,  C07J41/00 ,  C07J51/00 ,  A61K31/56 ,  C07J53/00

CPC classification number: C07J3/005 ,  C07J3/00 ,  C07J31/006 ,  C07J41/0005 ,  C07J41/0011 ,  C07J41/0027 ,  C07J41/0061 ,  C07J41/0066 ,  C07J41/0088 ,  C07J41/0094 ,  C07J51/00 ,  C07J7/0005 ,  C07J7/002 ,  C07J7/007 ,  C07J9/005

Abstract: nor-Bile acid derivatives, processes for their preparation and the use of these compounds as medicaments nor-Bile acid derivatives of the formula IG1--X--G2 Iin which G1, G2 and X have the meanings given, processes for the preparation of these compounds and medicaments are described. On the basis of their pharmacological action, they can be used as an antihyperlipidemic agent.

Abstract translation: D-胆汁酸衍生物，其制备方法和这些化合物作为药物的用途，其中G1，G2和X具有给定的含义，式I G1-X-G2I的胆汁酸衍生物，其制备方法 描述了化合物和药物。 在其药理作用的基础上，可以用作抗高血脂药。

公开(公告)号：US5466815A

公开(公告)日：1995-11-14

申请号：US238741

申请日：1994-05-05

Applicant: Alfons Enhsen ,  Heiner Glombik ,  Werner Kramer ,  Gunther Wess

Inventor： Alfons Enhsen ,  Heiner Glombik ,  Werner Kramer ,  Gunther Wess

IPC: A61K31/575 ,  A61K31/58 ,  A61K31/675 ,  A61P3/06 ,  A61P9/10 ,  C07J9/00 ,  C07J17/00 ,  C07J41/00 ,  C07J43/00 ,  C07D257/06 ,  A61K31/41

CPC classification number: C07J9/005 ,  C07J17/00 ,  C07J41/0005 ,  C07J41/0094 ,  C07J43/003

Abstract: The invention relates to tetrazole derivatives of bile acids, processes for their preparation, and use of these compounds as medicaments and cholesterol lowering agents. The tetrazole-bile acid derivatives are of the formula G1--X--G2, where G1 is H, a bile acid radical, or a bile acid radical which is modified on the hydroxyl functions and/or on the carboxyl group, X is a single bond or a bridge group between G1 and G2, and G2 is of the formula: ##STR1##

Abstract translation: 本发明涉及胆汁酸的四唑衍生物，其制备方法，以及这些化合物作为药物和降胆固醇剂的用途。 四唑 - 胆汁酸衍生物具有式G1-X-G2，其中G1是H，胆酸基或在羟基官能团和/或羧基上被修饰的胆汁酸基，X是单 键或G1和G2之间的桥组，G2是下式：