公开(公告)号：US20210040518A1

公开(公告)日：2021-02-11

申请号：US17072696

申请日：2020-10-16

申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

发明人： Jeong Woo SEO ,  Jong Jae YI ,  Sun Yeon HEO ,  Young Bae KIM ,  Chul Ho KIM ,  Baek Rock OH ,  Jung Hyun JU ,  Hack Sun CHOI

IPC分类号： C12P7/64 ,  C12N9/02 ,  C11C3/00 ,  C12P17/02 ,  A61P35/00

摘要： The present invention relates to a novel enzyme capable of producing multi-hydroxy derivatives from polyunsaturated fatty acids and a method for producing multi-hydroxy derivatives of polyunsaturated fatty acids using the same.

公开(公告)号：US20240000680A1

公开(公告)日：2024-01-04

申请号：US17767425

申请日：2019-12-06

申请人： KOLON INDUSTRIES, INC. ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

发明人： Jeong Woo SEO ,  Jong Jae Yl ,  Sun Yeon HEO ,  JungHyun JU ,  Chul Ho KIM ,  Baek Rock OH ,  Gil Yong LEE ,  Kyung Min LEE ,  Hee Won CHO

IPC分类号： A61K8/365 ,  A61Q19/08 ,  C12P7/6432 ,  C12P7/6434 ,  C12N9/02

CPC分类号： A61K8/365 ,  A61Q19/08 ,  C12P7/6432 ,  C12P7/6434 ,  C12N9/0069 ,  C12Y113/11012 ,  A61K2800/782 ,  A61K2800/5922

摘要： The present invention relates to an enzyme for producing hydroxy derivatives of polyunsaturated fatty acids, a method for producing hydroxy derivatives of polyunsaturated fatty acids using the same, and an SPMs complex composition containing the hydroxy derivatives of polyunsaturated fatty acids.
The enzyme may produce hydroxy derivatives of polyunsaturated fatty acids in a single reaction, and thus may be very usefully used for in vitro production. In addition, the SPMs complex composition containing the hydroxy derivatives of polyunsaturated fatty acids promotes collagen production, inhibits the production of NO and expression of TNF-α and IL-6, increases the expression of filaggrin and loricrin, and thus may be usefully used for preventing or alleviating skin aging or wrinkles, strengthening skin barrier, or preventing, alleviating or treating skin diseases comprising atopic dermatitis.

公开(公告)号：US20240327883A1

公开(公告)日：2024-10-03

申请号：US18600576

申请日：2024-03-08

申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

发明人： Jeong Woo SEO ,  Jong Jae YI ,  Sun Yeon HEO ,  Young Bae KIM ,  Chul Ho KIM ,  Baek Rock OH ,  Jung Hyun JU ,  Hack Sun CHOI

IPC分类号： C12P7/6427 ,  A61P35/00 ,  C11C3/00 ,  C12N9/02 ,  C12P7/6432 ,  C12P7/6434 ,  C12P17/02

CPC分类号： C12P7/6427 ,  A61P35/00 ,  C11C3/00 ,  C12N9/0069 ,  C12P7/6432 ,  C12P7/6434 ,  C12P17/02

摘要： The present invention relates to a novel enzyme capable of producing multi-hydroxy derivatives from polyunsaturated fatty acids and a method for producing multi-hydroxy derivatives of polyunsaturated fatty acids using the same.