专利检索 ap:("KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY") AND inv:"Hak Suk Chung" 第 1 页

1.

发明授权
Method of screening inhibitor of caspase activity by lipopolysaccharide 有权

公开(公告)号：US11926860B2

公开(公告)日：2024-03-12

申请号：US17485606

申请日：2021-09-27

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Hak Suk Chung , Jinsu An , Eun Gyeong Yang , So Yeon Kim

IPC分类号： C12Q1/02 , C12N9/64 , G01N33/58

CPC分类号： C12Q1/025 , C12N9/6472 , C12Y304/22057 , C12Q2527/127 , C12Y304/22036 , C12Y304/22055 , C12Y304/22056 , C12Y304/22062 , C12Y304/22064 , G01N33/582 , G01N2400/50 , G01N2500/00

摘要： Provided are a method of screening an inhibitor of caspase activity by lipopolysaccharide and a method of screening a therapeutic agent for inflammatory diseases or sepsis using the same. Accordingly, it is possible to develop a caspase-4-specific inhibitor.

2.

发明授权
Bacterium producing monophosphoryl lipid A and method of producing monophosphoryl lipid A by using bacterium 有权

公开(公告)号：US10308945B2

公开(公告)日：2019-06-04

申请号：US15378681

申请日：2016-12-14

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Hak Suk Chung , Eun Gyeong Yang , Dohyeon Hwang

IPC分类号： C12P19/12 , C12N15/70 , C12N9/10 , C12N9/16 , C12N15/52 , C12N15/74

摘要： A bacterium producing monophosphoryl lipid A (MLA) comprising a genetic modification that increases expression of a gene encoding LpxE polypeptide and a method of producing MLA are provided. According to the present invention, MLA may be produced in a simple manner without acid hydrolysis and/or base hydrolysis.

3.

发明授权
Bacterium constitutively producing monophosphoryl lipid A and method of producing monophosphoryl lipid A by using bacterium 有权

公开(公告)号：US10557156B2

公开(公告)日：2020-02-11

申请号：US16026796

申请日：2018-07-03

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Hak Suk Chung , Yu Hyun Ji , Jin Su An , Ick Chan Kwon , Eun Gyeong Yang

IPC分类号： C12P19/12 , C12N9/16 , C12N9/14 , C12P7/64

摘要： A bacterium that constitutively produces monophosphoryl lipid A (MLA) and a method of producing MLA by using the bacterium may simply produce MLA and a derivative thereof without acid hydrolysis, reduce a probability of natural mutation, and increase yields of MLA and a derivative thereof by constitutive expression of the MLA and derivative thereof.

4.

发明申请
BACTERIUM CONSTITUTIVELY PRODUCING MONOPHOSPHORYL LIPID A AND METHOD OF PRODUCING MONOPHOSPHORYL LIPID A BY USING BACTERIUM 审中-公开

公开(公告)号：US20190010528A1

公开(公告)日：2019-01-10

申请号：US16026796

申请日：2018-07-03

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Hak Suk Chung , Yu Hyun Ji , Jin Su An , Ick Chan Kwon , Eun Gyeong Yang

IPC分类号： C12P19/12 , C12N9/16 , C12N9/14

摘要： A bacterium that constitutively produces monophosphoryl lipid A (MLA) and a method of producing MLA by using the bacterium may simply produce MLA and a derivative thereof without acid hydrolysis, reduce a probability of natural mutation, and increase yields of MLA and a derivative thereof by constitutive expression of the MLA and derivative thereof.