公开(公告)号：US20210138012A1

公开(公告)日：2021-05-13

申请号：US17150168

申请日：2021-01-15

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Dong Seon KIM ,  Yoon-Young SUNG ,  Yun Mi LEE ,  Eun Jung SON ,  Heung Joo YUK ,  Young-Sil LEE

IPC: A61K36/42 ,  A61P11/06 ,  A23L33/00 ,  A23L33/105

Abstract: A method for or treating respiratory disease according to an embodiment includes administering to a subject in need thereof an extract of Siraitia grosvenorii residuals as an effective component. The extract of Siraitia grosvenorii residuals has, in an animal model having asthma induced by ovalbumin (OVA), an effect of reducing airway hyper-responsiveness, inhibiting inflammatory cells in bronchoalveolar lavage fluid (BALF), reducing Th2 cytokines (IL-4, IL-5, and IL-13) in BALF, reducing inflammation and tissue damage in lung tissues, inhibiting contraction of airway smooth muscle and airway inflammation, an effect of inhibiting expression of IL-13, TARC, TNF-α, IL-17, and MUC5AC, which is a gene encoding mucus protein, in lung tissues, an effect of reducing the level of ovalbumin-specific IgE in blood serum, and an effect of reducing ROS in alveolar cells which is generated in excess amount due to fine dust.

公开(公告)号：US20190099465A1

公开(公告)日：2019-04-04

申请号：US16086672

申请日：2017-04-07

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Dong Seon KIM ,  Ohn Soon KIM ,  Yun Mi LEE ,  Young-Sil LEE ,  Eun Jung SON

IPC: A61K36/9062 ,  A61K45/06 ,  A61P19/06 ,  A23L33/105

CPC classification number: A61K36/9062 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/30 ,  A23V2250/21 ,  A61K45/06 ,  A61K2236/331 ,  A61P19/06

Abstract: The present invention relates to a composition for preventing, ameliorating, or treating hyperuricemia or metabolic disorders related with hyperuricemia comprising an extract of Alpinia oxyphylla as an effective ingredient. Because the extract of Alpinia oxyphylla of the present invention can reduce the uric acid amount in blood of an animal model and is derived from natural products, and the raw materials can be easily obtained, it can be widely used in industries that are related to hyperuricemia or metabolic disorders related with hyperuricemia. It can be effectively used for prevention, amelioration, or treatment of gout or gouty arthritis, in particular.

公开(公告)号：US20200268827A1

公开(公告)日：2020-08-27

申请号：US16646387

申请日：2018-09-12

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Dong Seon KIM ,  Yun Mi LEE ,  Eun Jung SON ,  Ji Youn KIM

IPC: A61K36/9062 ,  A61P19/02

Abstract: A method for treating osteoarthritis according to an embodiment of the present invention includes administering to a subject in need thereof a composition comprising an extract of Alpinia oxyphylla. The extract of Alpinia oxyphylla can reduce the expression of IL-1β, IL-6, TNF-α and COX-2 as an inflammatory factor and also the expression of MMP-9 as a cartilage degeneration-inducing factor, and can heal the cartilage damage, and thus it can be advantageously used as a functional health food composition for prevention or improvement of osteoarthritis or a therapeutic agent for osteoarthritis.

公开(公告)号：US20240123015A1

公开(公告)日：2024-04-18

申请号：US18278227

申请日：2021-12-13

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Dong Seon KIM ,  Young Sook KIM ,  Heung Joo YUK ,  Yun Mi LEE ,  Yoon-Young SUNG ,  Eun Jung SON

IPC: A61K36/538 ,  A61P21/00

CPC classification number: A61K36/538 ,  A61P21/00 ,  A61K2236/331 ,  A61K2236/333

Abstract: A composition for strengthening, developing, differentiating, or regenerating muscle, or preventing, ameliorating, or treating muscle loss or muscle fatigue includes a Schizonepeta tenuifolia extract as an effective component. The Schizonepeta tenuifolia extract as an effective component has the effects of restoring the viability of muscle cells, increasing the endurance time on the rotarod performance test, i.e., the holding time without falling off from the rod, compared to the control group, reducing the content of LDH, AST, and ALT in blood, increasing the grip strength, enhancing the expression amount of energy metabolism-related genes in muscle tissues, increasing the density of muscle fibers in muscle tissues, inducing a change in the fibroblast arrangement to have a well-organized structure, and reducing the expression of MuRF1 in muscle tissues, as compared to the control group.

公开(公告)号：US20170354703A1

公开(公告)日：2017-12-14

申请号：US15539239

申请日：2015-12-18

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Dong Seon KIM

IPC: A61K36/54 ,  A61K36/287

CPC classification number: A61K36/54 ,  A23L33/105 ,  A61K36/28 ,  A61K36/287 ,  A61K2300/00 ,  A61P19/02 ,  A61P19/06

Abstract: An anti-gout composition including the mixed extract of Chrysanthemum indicum and Cinnamomum cassia as an active ingredient shows substantially greater inhibitory effects on xanthine oxidase than when Chrysanthemum indicum or Cinnamomum cassia is used separately. An animal model treated with the mixed extract of Chrysanthemum indicum and Cinnamomum cassia experienced a decrease in uric acid in serum and in urine. The mixed extract of Chrysanthemum indicum and Cinnamomum cassia is an active ingredient induced from a natural material, and, accordingly, the mixed extract is safe and a source material therefor is easily provided. Accordingly, the mixed extract can be widely used in gout-related industries.