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公开(公告)号：US20210024981A1
公开(公告)日：2021-01-28
申请号：US16968992
申请日：2019-04-19
Inventor： Yoosik KIM , Raisa KHARBASH , Ahsan Ausaf ALI , Minjeong KANG
IPC: C12Q1/6809
Abstract: The merocyanine compound of the present invention causes a spectral change of a hypochromic shift in the vicinity of the wavelength of 512 nm by intercalation between dsRNA nucleotide pairs, and the spectral change shows high accuracy and reproducibility, so the merocyanine compound of the present invention can be effectively used for detecting dsRNA and comparing the expression levels between samples. In addition, the present invention relates to a method for providing information for the diagnosis of cancer comprising the steps of 1) measuring the expression level of dsRNA in a sample of a test subject; and 2) comparing the expression level of dsRNA measured in step 1) with that of the normal control group, and a composition for detecting dsRNA comprising a merocyanine compound, a salt thereof or an isomer thereof. The present invention can provide information for the diagnosis of cancer by measuring the expression level of dsRNA separated from a sample of a test subject and comparing it with that of the normal control group. Further, the responsiveness of a patient to the treated drug can be predicted by treating the sample with a drug and measuring the expression level of dsRNA.
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Patent Agency Ranking
公开(公告)号：US20210026239A1
公开(公告)日：2021-01-28
申请号：US16968084
申请日：2019-12-13
Inventor： Heon KIM , Yoosik KIM , Raisa KHARBASH , Se Hyun KWON , Yeongrae CHANG , Seokhoon JANG
Abstract: Provided is a photopolymer composition for hologram recording comprising: a polymer matrix or a precursor thereof; a dye including a compound of the following Chemical Formula 1; a photoreactive monomer; and a photoinitiator,
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公开(公告)号：US20230193262A1
公开(公告)日：2023-06-22
申请号：US17842888
申请日：2022-06-17
Inventor： Yoosik KIM , Hyun Gyu PARK , HANSOL KIM , ryeongeun CHO , JIN A LIM , DOYEONG KU
IPC: C12N15/113 , A61K31/713 , A61P35/00
CPC classification number: C12N15/113 , A61K31/713 , A61P35/00 , C12N2310/141 , A61K45/06
Abstract: This application pertains to a hairpin nucleic acid molecule capable of modulating expression of a target gene and a use thereof. A nucleic acid molecule according to an embodiment can modulate expression of a target gene in a specific manner for cells in which a miRNA hybridizable therewith is present, finding advantageous applications in compositions for regulating expression of a target gene or pharmaceutical compositions for treating diseases.
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公开(公告)号：US20200263038A1
公开(公告)日：2020-08-20
申请号：US16651906
申请日：2018-12-07
Inventor： Heon KIM , Yoosik KIM , Raisa KHARBASH , Se Hyun KWON , Yeongrae CHANG , Seokhoon JANG
Abstract: The present invention relates to a compound having a novel structure, a photopolymer composition including the compound as a dye, a hologram recording medium produced from the photopolymer composition, an optical element including the hologram recording medium, and a holographic recording method using the hologram recording medium.
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公开(公告)号：US20230129651A1
公开(公告)日：2023-04-27
申请号：US17842891
申请日：2022-06-17
Inventor： Hyun Gyu PARK , Yoosik KIM , HANSOL KIM , Jayeon SONG , JunHyeok YOON
IPC: C12N15/113 , A61P35/00
Abstract: This application pertains to a hairpin nucleic acid molecule capable of modulating expression of a target gene and a use thereof. A nucleic acid molecule according to an embodiment can modulate expression of a target gene in a specific manner for cells in which a miRNA hybridizable therewith is present, finding advantageous applications in compositions for regulating expression of a target gene or pharmaceutical compositions for treating diseases.
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公开(公告)号：US20210003919A1
公开(公告)日：2021-01-07
申请号：US16976206
申请日：2019-04-29
Inventor： Heon KIM , Yoosik KIM , Raisa KHARBASH , Se Hyun KWON , Yeongrae CHANG , Seokhoon JANG
Abstract: The present disclosure relates to a photopolymer composition, and more particularly, to a compound having a novel structure, a photopolymer composition including the compound as a dye, a hologram recording medium produced from the photopolymer composition, an optical element including the hologram recording medium, and a holographic recording method using the photopolymer composition.
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