公开(公告)号：US20210024981A1

公开(公告)日：2021-01-28

申请号：US16968992

申请日：2019-04-19

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Yoosik KIM ,  Raisa KHARBASH ,  Ahsan Ausaf ALI ,  Minjeong KANG

IPC: C12Q1/6809

Abstract: The merocyanine compound of the present invention causes a spectral change of a hypochromic shift in the vicinity of the wavelength of 512 nm by intercalation between dsRNA nucleotide pairs, and the spectral change shows high accuracy and reproducibility, so the merocyanine compound of the present invention can be effectively used for detecting dsRNA and comparing the expression levels between samples. In addition, the present invention relates to a method for providing information for the diagnosis of cancer comprising the steps of 1) measuring the expression level of dsRNA in a sample of a test subject; and 2) comparing the expression level of dsRNA measured in step 1) with that of the normal control group, and a composition for detecting dsRNA comprising a merocyanine compound, a salt thereof or an isomer thereof. The present invention can provide information for the diagnosis of cancer by measuring the expression level of dsRNA separated from a sample of a test subject and comparing it with that of the normal control group. Further, the responsiveness of a patient to the treated drug can be predicted by treating the sample with a drug and measuring the expression level of dsRNA.