公开(公告)号：US20230047716A1

公开(公告)日：2023-02-16

申请号：US17791528

申请日：2021-01-06

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY ,  PENTAMEDIX CO., LTD.

Inventor： Jung Kyoon CHOI ,  Hyo Eun BANG ,  Jae Soon PARK ,  Dae Yeon CHO

IPC: G16B5/20 ,  C12Q1/6886 ,  G16B40/00

Abstract: Provided are a method and system for screening neoantigen and uses of neoantigens. Specifically, provided are a method and system for screening neoantigens derived from a gene of which expression is essential for survival of a cancer cell and/or a is homogeneously expressed in all cells in cancer tissue as a diagnostic and/or therapeutic target, and uses of neoantigens.

公开(公告)号：US20240153591A1

公开(公告)日：2024-05-09

申请号：US18284368

申请日：2021-12-16

Applicant: PENTAMEDIX CO., LTD. ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jung Kyoon CHOI ,  Jeong Yeon KIM ,  Dae Yeon CHO

IPC: G16B40/20 ,  G06N3/0464 ,  G06N3/084

CPC classification number: G16B40/20 ,  G06N3/0464 ,  G06N3/084

Abstract: This method of predicting the T cell activation of peptide-MHC comprises the steps in which an analysis apparatus: receives genetic data of a patient; identifies, on the basis of the genetic data, a first amino acid sequence of a major histocompatibility complex (MHC) and a second amino acid sequence of antigen generated by tumor cells; produces a matrix indicating the interrelationship between the first amino acid sequence and the second amino acid sequence in a single amino acid unit; and inputs the matrix to a trained neural network model to determine whether the T cells secrete at least a threshold amount of cytokine as a result of the binding of the MHC and the antigen.

公开(公告)号：US20230383363A1

公开(公告)日：2023-11-30

申请号：US18251033

申请日：2021-11-03

Applicant: GC GENOME CORPORATION ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jung Kyoon CHOI ,  Hyeon Gu KANG ,  Eun Hae CHO

IPC: C12Q1/6886 ,  C12Q1/6869 ,  G16B30/00 ,  G16B20/10 ,  G16B40/20

CPC classification number: C12Q1/6886 ,  C12Q1/6869 ,  G16B30/00 ,  G16B20/10 ,  G16B40/20 ,  C12Q2600/106 ,  C12Q2600/158

Abstract: The present invention relates to a method for determining sensitivity to a PARP inhibitor or a DNA damaging agent by using a non-functional transcriptome, and more particularly, to a method for determining sensitivity to a PARP inhibitor or a DNA damaging agent by extracting nucleic acids from a biological sample to obtain the expression amount of each of non-functional transcriptomes of DNA repair-related genes, and then analyzing the use rate (TU) of each of the non-functional transcriptomes for each gene on the basis of the obtained expression amount. The method for determining sensitivity to a PARP inhibitor or a DNA damaging agent according to the present invention is useful in that sensitivity can be determined in real time with high accuracy because the method uses information of the transcriptomes transcribed in the gene, unlike existing methods which determine sensitivity to a PARP inhibitor or a DNA damaging agent on the basis of genetic variation information.

公开(公告)号：US20220367008A1

公开(公告)日：2022-11-17

申请号：US17625983

申请日：2020-07-07

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY ,  PENTAMEDIX CO., LTD.

Inventor： Jung Kyoon CHOI ,  Kiwon JANG ,  Dae Yeon CHO

IPC: G16B40/00 ,  G16B25/10

Abstract: A machine learning model-based essential gene identification method includes receiving, by an analysis apparatus, inputs of expression pattern information on genes of a specific cell; inputting, by the analysis apparatus, the expression pattern information to a machine learning model; and determining, by the analysis apparatus, whether a target gene from among the genes is essential in the survival of the cell on the basis of information output by the machine learning model.

公开(公告)号：US20250118441A1

公开(公告)日：2025-04-10

申请号：US18730634

申请日：2023-01-20

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sook Ryun PARK ,  Jung Kyoon CHOI ,  Jinhyeon AN ,  Changhwan SUNG

IPC: G16H50/30 ,  G16B20/20 ,  G16B40/20 ,  G16H10/40

Abstract: A SNP-based model for predicting the occurrence of irAEs induced by immunotherapy. The dbSNP database rs541169 and a single nucleotide polymorphism (SNP) site in the TMEM162 (FAM187B) gene are closely correlated with the occurrence of irAEs. The rs541169 can be advantageously used as a biomarker for predicting the occurrence of irAEs induced by immunotherapy or predicting responsiveness to immunotherapy.

公开(公告)号：US20250101516A1

公开(公告)日：2025-03-27

申请号：US18730595

申请日：2023-01-20

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sook Ryun PARK ,  Jung Kyoon CHOI ,  Jinhyeon AN ,  Changhwan SUNG

IPC: C12Q1/6881

Abstract: A method for predicting the occurrence of immune-related adverse events (irAEs) induced by an HLA type-based cancer immunotherapy agent. The method involves determining copy number variations (CNVs) of the HLA gene, such as HLA-B exon 2 deficiency, or HLA alleles such as HLA-B*35:01, HLA-B*40:02, HLA-B*54:01, or detecting an allele of an HLA gene selected from HLA-B*35:01, HLA-B*40:02, and HLA-B*54:01, in a biological sample isolated from a subject, and treating the cancer immunotherapy-induced irAE in the subject by administering to the subject a corticosteroid or immunosuppressant.

公开(公告)号：US20240392385A1

公开(公告)日：2024-11-28

申请号：US18696031

申请日：2022-09-29

Applicant: PentaMedix Co., Ltd. ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jung Kyoon CHOI ,  Kyeong Hui KIM ,  In Kyung SHIN ,  Seung Jae NOH ,  Dae Yeon CHO

IPC: C12Q1/6886

Abstract: The present disclosure relates to a method for providing information for predicting a response to cancer therapy, comprising the step of obtaining information on a DNA methylation level of a long interspersed nuclear element-1 (LINE-1) subfamily from an isolated sample of a cancer patient, wherein the LINE-1 subfamily is at least one selected from the group consisting of LIPA12_5end, LIHS_5end, L1PA10_3end, LIP2_5end, L1PA11_3end, L1P2_5end, L1PA13_3end, L1PA11_3end, and LIP1_orf2.

公开(公告)号：US20240127908A1

公开(公告)日：2024-04-18

申请号：US18142958

申请日：2024-01-03

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jung Kyoon CHOI ,  Joon Ha KWON

IPC: G16B40/00 ,  G16B25/10

CPC classification number: G16B40/00 ,  G16B25/10

Abstract: A method for discovering a target antigen for a chimeric antigen receptor comprises the steps of: obtaining, by an analysis apparatus, expression information of genes of tumor cells in single cell units; extracting, by the analysis apparatus, from among the genes, genes of candidate antigens having an expression level of a reference value or more; determining, by the analysis apparatus, all possible gene combinations that can be constituted by the genes of the candidate antigens; and determining, by the analysis apparatus, a target gene combination in which at least one gene included therein is expressed, among the gene combinations.