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1.发明公开公开(公告)号：US20230210888A1
公开(公告)日：2023-07-06
申请号：US18062806
申请日：2022-12-07
Applicant: Korea University Research and Business Foundation , Chung Ang University Industry Academic Cooperation Foundation , KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Kyeongsoon PARK , Jin Won KIM , Hongki YOO , Jin Hyuk KIM
IPC: A61K31/716 , A61K49/00 , A61P9/10
CPC classification number: A61K31/716 , A61K49/0017 , A61P9/10 , B82Y5/00
Abstract: The present disclosure provides nanoparticles including laminarin and a near-infrared responsive photosensitizer covalently bonded thereto, and a composition for preventing, diagnosing, or treating arteriosclerosis comprising the same as an active ingredient. According to the present disclosure, not only the atherosclerotic plaque targeting and plaque-penetrating properties can be enhanced as compared to conventional photodynamic therapy, thus capable of being usefully used for in vivo imaging of atherosclerotic plaques, but also the size of atherosclerotic plaques is reduced by inducing apoptosis of macrophages in atherosclerotic plaques, thus capable of stabilizing atherosclerotic plaques. Therefore, the composition comprising the nanoparticles of the present disclosure as an active ingredient is expected to be usefully used for the prevention, diagnosis and/or treatment of arteriosclerosis, in that photodynamic therapy and image diagnostic of arteriosclerosis can be performed simultaneously or sequentially.
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2.发明公开公开(公告)号：US20240185627A1
公开(公告)日：2024-06-06
申请号：US18553290
申请日：2022-03-28
Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY , KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
Inventor： Hongki YOO , Hyeong Soo NAM , Jin Won KIM , Sun Won KIM
CPC classification number: G06V20/698 , G06T7/0012 , G06T2207/10064 , G06T2207/10101 , G06T2207/20084 , G06T2207/30101 , G06V2201/03
Abstract: An operation method of an analysis device operated by at least one processor includes: receiving a fusion image; and classifying tissue components in the fusion image using an artificial intelligence model. The fusion image includes first information obtained by imaging vascular tissue through an optical coherence tomography device, and second information obtained by imaging the vascular tissue through a fluorescence lifetime imaging device. The artificial intelligence model is a model trained to classify tissue components using structural features and fluorescence lifetime image information included in an input image.
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公开(公告)号：US20250150711A1
公开(公告)日：2025-05-08
申请号：US18624266
申请日：2024-04-02
Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY , Korea University Research and Business Foundation
Inventor： Hongki YOO , Minseok JANG , Jin Won KIM , Joon Woo SONG
Abstract: A method for capturing in vivo images by a control device which operates by at least one processor includes: acquiring 1dimensional (D) images acquired by scanning in vivo samples in one direction from a confocal microscopy including a focus variable lens; estimating motion information of the in vivo sample from the 1D images; generating a driving signal for synchronizing and varying a focal plane of the focus variable lens with a motion of the in vivo sample based on the estimated motion information, and controlling the focus variable lens with the driving signal; and acquiring, from the confocal microscopy, continuous images of the in vivo sample scanned in the focal plane varied according to the driving signal.
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公开(公告)号：US20220146427A1
公开(公告)日：2022-05-12
申请号：US17583658
申请日：2022-01-25
Inventor： Hongki YOO , Wooseop KIM , Juehyung KANG , Ungyo KANG
Abstract: The multi-photon microscope comprises a repetition rate tuner that lowers an optical pulse train emitted from a pulsed laser to a repetition rate for time-gated detection, a scanner that scans the optical pulse train transmitted from the repetition rate tuner in x-axis and y-axis directions, an objective lens that irradiates an optical signal scanned by the scanner to the sample and acquires a fluorescence signal emitted from the excited fluorescent material, a photodetector that photoelectrically converts the fluorescence signal acquired by the objective lens, an amplifier that converts a current signal output from the photodetector into a voltage signal, a digitizer that samples the voltage signal output from the amplifier, and a computing device that separates sampling data output from the digitizer with a detection window set in time domain, and generates an image based on the sampling data separated by the detection window.
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