公开(公告)号：US20180037896A1

公开(公告)日：2018-02-08

申请号：US15545311

申请日：2016-04-11

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sang Yup Lee ,  Tong Un Chae ,  Chan Woo Song

IPC: C12N15/79 ,  C08G69/14 ,  A61K35/742 ,  C12N15/52

Abstract: The present disclosure relates to a recombinant microorganism having a lactam production capacity from an omega-amino acid, into which a gene encoding a beta-alanine coenzyme A transferase on a microorganism which has an omega-amino acid biosynthetic metabolic pathway inherently or an omega-amino acid biosynthetic metabolic pathway is introduced, and a method for producing a variety of lactams and omega-amino acyl-CoAs using the same.The recombinant microorganism and the method for producing the lactam according to the present disclosure are useful in producing a variety of lactams such as propiolactam, 2-pyrrolidone, valerolactam, caprolactam, and heptanolactam from a variety of omega-amino acids.

公开(公告)号：US20180051291A1

公开(公告)日：2018-02-22

申请号：US15556458

申请日：2016-03-17

Applicant: Korea Advanced Institute of Science and Technology

Inventor： Sang Yup Lee ,  Tong Un Chae ,  Chan Woo Song

IPC: C12N15/52 ,  C12N1/20 ,  C12N15/01 ,  C12N15/63

CPC classification number: C12N15/52 ,  C12N1/20 ,  C12N9/88 ,  C12N15/01 ,  C12N15/63 ,  C12P7/40 ,  C12P7/42 ,  C12P13/001 ,  C12P13/005 ,  C12P13/04 ,  C12P13/06 ,  C12R1/00

Abstract: The present invention relates to a mutant organism having the ability to produce aspartic acid derivatives, wherein a gene encoding the glyoxylate shunt regulator and a gene encoding fumarase are deleted and a gene encoding aspartase is overexpressed compared to that in a wild-type strain, and to a method for producing L-aspartic acid derivatives using the same. According to the present invention, various aspartic acid derivatives, including L-alanine, 3-aminopropionic acid, threonine, 1,3-diaminopropane, lysine, methionine, 3-hydroxypropionic acid, cadaverine, 5-aminovaleric acid, etc., can be produced by biological methods.

公开(公告)号：US10683512B2

公开(公告)日：2020-06-16

申请号：US15545311

申请日：2016-04-11

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sang Yup Lee ,  Tong Un Chae ,  Chan Woo Song

IPC: C12N15/52 ,  C12N15/79 ,  C12P17/10 ,  C12N9/10 ,  A61K35/742 ,  C08G69/14

Abstract: The present disclosure relates to a recombinant microorganism having a lactam production capacity from an omega-amino acid, into which a gene encoding a beta-alanine coenzyme A transferase on a microorganism which has an omega-amino acid biosynthetic metabolic pathway inherently or an omega-amino acid biosynthetic metabolic pathway is introduced, and a method for producing a variety of lactams and omega-amino acyl-CoAs using the same.The recombinant microorganism and the method for producing the lactam according to the present disclosure are useful in producing a variety of lactams such as propiolactam, 2-pyrrolidone, valerolactam, caprolactam, and heptanolactam from a variety of omega-amino acids.

公开(公告)号：US10472636B2

公开(公告)日：2019-11-12

申请号：US15556458

申请日：2016-03-17

Applicant: Korea Advanced Institute of Science and Technology

Inventor： Sang Yup Lee ,  Tong Un Chae ,  Chan Woo Song

IPC: C12N1/20 ,  C12N15/52 ,  C12N9/88 ,  C12N15/63 ,  C12P7/40 ,  C12N15/01 ,  C12P7/42 ,  C12P13/00 ,  C12P13/04 ,  C12P13/06 ,  C12R1/00

Abstract: The present invention relates to a mutant organism having the ability to produce aspartic acid derivatives, wherein a gene encoding the glyoxylate shunt regulator and a gene encoding fumarase are deleted and a gene encoding aspartase is overexpressed compared to that in a wild-type strain, and to a method for producing L-aspartic acid derivatives using the same. According to the present invention, various aspartic acid derivatives, including L-alanine, 3-aminopropionic acid, threonine, 1,3-diaminopropane, lysine, methionine, 3-hydroxypropionic acid, cadaverine, 5-aminovaleric acid, etc., can be produced by biological methods.