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公开(公告)号：US10792340B2
公开(公告)日：2020-10-06
申请号：US15563795
申请日：2016-04-04
发明人： Yeong Min Park , In Duk Jung , Seung Jun Lee
摘要： Provided is an antibacterial composition against carbapenem-resistant gram-negative bacteria which includes, as an active ingredient, adenylate kinase (ADK) protein derived from Mycobacterium tuberculosis. The ADK protein derived from Mycobacterium tuberculosis, according to the subject matter, has excellent antimicrobial activity against carbapenem-resistant gram-negative bacteria, and thus may be usefully used in a variety of fields as an antibacterial composition.
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公开(公告)号：US10736944B2
公开(公告)日：2020-08-11
申请号：US16120603
申请日：2018-09-04
发明人： Yeong Min Park , In Duk Jung , Sung Jae Shin , Jung Hee Park , Seung Jun Lee , Tae Heung Kang , Byoung Yul Soh
摘要： The present invention relates to a composition for preventing or treating sepsis or septic shock including a Mycobacterium tuberculosis-derived adenosine kinase (ADK) protein as an active ingredient. The Mycobacterium tuberculosis-derived ADK protein according to one exemplary embodiment of the present invention has an effect of inhibit binding between the LPS and cells by binding to LPS, and also has an excellent therapeutic effect against sepsis by enhancing viability in a sepsis animal model and suppressing inflammatory response in the lung and cell death in the spleen.
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公开(公告)号：US10543258B2
公开(公告)日：2020-01-28
申请号：US15534979
申请日：2015-12-10
发明人： Yeong Min Park , In Duk Jung , Yong Taik Lim , Jung Hee Park , Sung Jae Shin
IPC分类号： A61K38/00 , A61K38/45 , A61P31/04 , A61K31/345 , A61K31/43 , A61K31/47 , A61K31/545 , A61K31/65 , A61K31/7036 , C12N9/12
摘要： The present invention relates to an antibacterial composition containing, as an active ingredient, adenylate kinase or adenosine kinase (ADK) protein derived from Mycobacterium tuberculosis, and a composition for preventing or treating infectious diseases. In addition, the present invention relates to a composition for preventing or treating sepsis or septic shock. Furthermore, the present invention relates to a method for preventing, improving or treating an infectious disease comprising administering the present antibacterial composition. The ADK protein derived from Mycobacterium tuberculosis according to the present invention has excellent antibacterial activity selectively against gram-negative bacteria, and thus can be favorably used as an antibacterial composition against gram-negative bacteria or for the prevention or treatment of infectious diseases caused by gram-negative bacteria. In addition, the ADK protein has an excellent sepsis treatment effects, thus can be favorably used for the prevention or treatment of sepsis or septic shock.
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