公开(公告)号：US11284910B2

公开(公告)日：2022-03-29

申请号：US15780248

申请日：2016-12-07

Applicant: KONINKLIJKE PHILIPS N.V. ,  BRACCO SUISSE SA

Inventor： Scott William Dianis ,  Jeffry Earl Powers ,  Ralf Seip ,  William Tao Shi ,  Yannick Bohren ,  Emmanuel Jean-Marie Gaud ,  Jean-Marc Paul Robert Hyvelin

IPC: A61B17/22 ,  A61B8/06 ,  A61B8/14 ,  A61B8/08 ,  A61B17/00

Abstract: A therapeutic ultrasound system transmits a staggered or interleaved pattern of therapy beams for use in sonothrombolysis and other Vascular Acoustic Resonators (VAR) mediated therapy. The inventive technique minimizes VAR, e.g. microbubble, destruction due to adjacent beams, ensures uniform sonication of the targeted region by filling in the spaces between the beams in subsequent passes, and further provides a means for bubble replenishment to maximize the clot lysis from ultrasound. The technique is also applicable to diagnostic ultrasound, VAR mediated drug delivery and blood brain barrier opening.

公开(公告)号：US11141179B2

公开(公告)日：2021-10-12

申请号：US15534549

申请日：2015-11-23

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Ralf Seip ,  Sonia Souza ,  Jeffry Earl Powers ,  William Tao Shi ,  Terrence James Sweeney ,  Sarah Rhoades Baxter

IPC: A61B17/225 ,  A61B8/08 ,  A61N7/00 ,  A61B17/22 ,  A61B34/00 ,  A61B90/00 ,  A61B17/00

Abstract: An apparatus for patient-specific adjusting of ultrasound output pressure includes a controller (118) configured for adjusting, based on an estimate of thickness of a temporal bone (140) in a head of a medical treatment recipient, a pressure setting. It may also be based on treatment depth (134). Ultrasound at the adjusted pressure setting is applied. A user interface may be provided for user entry of the estimate, the user interface being further configured for user indication of the treatment depth. Both the entered estimate and the indicated treatment depth may be used in calculating ultrasound attenuation (148). The user indication can be interactive by virtue of designating, on a display, a location of a treatment target. The calculated attenuation may be a value, in decibels, that is in a range from 0.9×(2.70×0.1+16.60×T+0.87×(D−T−0.1)+3.02) to 1.1×(2.70×0.1+16.60×T+0.87×(D−T−0.1)+3.02), where T is the estimate in centimeters and D is the treatment depth in centimeters.

公开(公告)号：US10960194B2

公开(公告)日：2021-03-30

申请号：US14901293

申请日：2014-06-25

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Jeffry Earl Powers ,  William Tao Shi ,  John Douglas Fraser ,  Ralf Seip ,  Francois Guy Gerard Marie Vignon

IPC: A61M37/00 ,  A61B8/06 ,  A61B8/08 ,  A61N7/00 ,  A61B8/00 ,  A61B34/20 ,  A61B90/00

Abstract: An apparatus for ultrasound irradiation of a body part (208) includes a first ultrasound transducer (216), and a second ultrasound transducer (212) mounted oppositely, and is configured: a) such that at least two ultrasound receiving elements, for determining a relative orientation of the first to the second transducer, are attached to the first transducer; b) for a beam, from the first transducer, causing cavitation, and/or bubble destruction of systemically circulating microbubbles, within the body part; or c) both with the attached elements and for the causing. The apparatus registers, with said first transducer, the second transducer, by using as a reference respectively the features a) and/or b). A detachable subsystem includes either a therapy or imaging transducer, to form a combination imaging and therapy system, the subsystem being configured for removable coupling to correspondingly an imaging or therapy subsystem comprising a head frame (204) to which is mounted an imaging or therapy transducer, the imaging or therapy subsystem for registering the imaging or therapy transducer, one to the other, by the above method.

公开(公告)号：US20220133277A1

公开(公告)日：2022-05-05

申请号：US17576389

申请日：2022-01-14

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： William Tao Shi ,  Jonathon Thomas Sutton ,  Jeffry Earl Powers ,  Ralf Seip

IPC: A61B8/08 ,  A61B8/06 ,  A61N7/00

Abstract: A therapeutic ultrasound method configured to adaptively transmit ultrasound pulses toward microbubbles in a treatment region to remove an occlusion is described. In some examples, the system may include a treatment pulse unit configured to transmit an ultrasound pulse to a treatment region of a subject, the treatment region including a plurality of microbubbles. An echo detection unit may be configured to receive one or more echoes responsive to the ultrasound pulse. In some examples, the method may also include a data processor configured to identify, using data associated with the echoes, at least one echo signature indicative of a dynamic state of the microbubbles in response to the ultrasound pulse. A controller may be configured to adjust one or more parameters of an additional ultrasound pulse transmitted to the treatment region via the treatment pulse unit based on the at least one echo signature.

公开(公告)号：US10888307B2

公开(公告)日：2021-01-12

申请号：US15119077

申请日：2015-02-26

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Aleksandra Popovic ,  Ralf Seip ,  David Paul Noonan

IPC: A61B17/00 ,  A61B17/11 ,  A61B17/12 ,  A61B18/24 ,  A61N7/02 ,  A61B17/22 ,  A61B34/20 ,  A61B17/32 ,  A61B17/30

Abstract: A method of performing a coronary bypass procedure is performed by a flexible apparatus controlled by at least one controller, the method may include acts of: percutaneously situating the flexible apparatus into a first artery coupled to connective tissue of a chest wall; transluminally detaching at least a portion of the first artery from the connective tissue by applying ultrasound signals of a first type emitted by at least one transducer of the flexible apparatus; steering at least a portion of the detached portion first artery from a current location to a bypass location at a target artery by applying a force transmitted through the flexible apparatus situated within the first artery; and coupling, by the flexible apparatus situated within the first artery, the first artery to the target artery at the bypass location to establish flow communication between the first artery and the target artery.

公开(公告)号：US10213184B2

公开(公告)日：2019-02-26

申请号：US14435539

申请日：2013-10-10

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Maarten Johan Frido Rincker ,  Juliana Pauline Kelly ,  Ralf Seip ,  Jeffry Earl Powers ,  William Tao Shi ,  Helle Ullerup ,  Davy Maria Willibrordus Schaeken ,  Terrence James Sweeney

IPC: A61B8/00 ,  A61B8/08 ,  A61G1/04 ,  A61N7/00 ,  A61B8/06 ,  A61B90/14

Abstract: A head frame for a medical patient includes support for a probe and a neck support. The frame wraps around the head of the patient and can be used in the supine position. The support may include a probe holder slidable under the head and configured to contact or engage the neck support. In some embodiments, conformal shaping to the head and/or neck of the patient, the frame's rigid construction, the alignment of the optionally separable holder to the neck support, the weight of the head, or a combination thereof serve to keep the distal tip of the ultrasound probe in place against the temporal region of the head without need for attaching the frame to the head as by straps, which may provide an arrangement robust against patient/vehicle movement in an emergency medical services setting.

公开(公告)号：US20180185040A1

公开(公告)日：2018-07-05

申请号：US15735981

申请日：2016-06-23

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Ralf Seip ,  Evgeniy Leyvi ,  Balasundar Iyyavu Raju

IPC: A61B17/22 ,  A61M5/145 ,  A61N7/00 ,  B01F13/00 ,  B01F13/08

Abstract: An infusion system for sonothrombolysis treatment uses a syringe loaded with a microbubble solution and operated by a syringe pump to deliver the microbubble solution to a subject during sonothrombolysis treatment. To prevent the stratification of the microbubble solution in the barrel of the syringe during treatment, the barrel also contains a plurality of magnetic beads which are agitated into semi-random patterns of motion in the syringe chamber during the procedure. The magnetic beads are moved by magnetic attraction and repulsion from the moving magnets of a magnetic stirrer mounted in proximity to the syringe during treatment.

公开(公告)号：US11950958B2

公开(公告)日：2024-04-09

申请号：US17576389

申请日：2022-01-14

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： William Tao Shi ,  Jonathon Thomas Sutton ,  Jeffry Earl Powers ,  Ralf Seip

IPC: A61B8/00 ,  A61B8/06 ,  A61B8/08 ,  A61N7/00

CPC classification number: A61B8/481 ,  A61B8/06 ,  A61B8/0816 ,  A61B8/0891 ,  A61N7/00 ,  A61N2007/0039

Abstract: A therapeutic ultrasound method configured to adaptively transmit ultrasound pulses toward microbubbles in a treatment region to remove an occlusion is described. In some examples, the system may include a treatment pulse unit configured to transmit an ultrasound pulse to a treatment region of a subject, the treatment region including a plurality of microbubbles. An echo detection unit may be configured to receive one or more echoes responsive to the ultrasound pulse. In some examples, the method may also include a data processor configured to identify, using data associated with the echoes, at least one echo signature indicative of a dynamic state of the microbubbles in response to the ultrasound pulse. A controller may be configured to adjust one or more parameters of an additional ultrasound pulse transmitted to the treatment region via the treatment pulse unit based on the at least one echo signature.

公开(公告)号：US20160317129A1

公开(公告)日：2016-11-03

申请号：US15104577

申请日：2014-12-08

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Ralf Seip ,  Sandeep M. Dalal

IPC: A61B8/08 ,  A61N7/00 ,  A61B6/00 ,  A61B6/03

CPC classification number: A61B8/5261 ,  A61B6/032 ,  A61B6/504 ,  A61B8/0808 ,  A61B8/0891 ,  A61B8/483 ,  A61B8/488 ,  A61B2090/364 ,  A61B2090/378 ,  A61N7/00 ,  A61N7/02 ,  A61N2007/0004 ,  A61N2007/0052 ,  A61N2007/0095

Abstract: A method and system for treating a target area of a patient, for example an area of the brain which includes an occlusion: employ an ultrasound imaging apparatus to produce an ultrasound image of a region of a subject; register the ultrasound image to a computed tomography (CT) image dataset; identify in the ultrasound image a location of a target area via a marker of the target area produced from the CT image dataset; verify the location of the target area with the ultrasound imaging apparatus; and provide sonothrombolysis treatment to the target area while monitoring the target area with the ultrasound imaging apparatus.

Abstract translation: 用于治疗患者的目标区域的方法和系统，例如包括闭塞的大脑区域：采用超声成像设备产生受试者的区域的超声图像; 将超声图像记录到计算机断层摄影（CT）图像数据集; 通过CT图像数据集产生的目标区域的标记，在超声图像中识别目标区域的位置; 使用超声成像设备验证目标区域的位置; 并且在用超声波成像装置监视目标区域的同时，向目标区域提供声波溶解处理。

公开(公告)号：US10695078B2

公开(公告)日：2020-06-30

申请号：US15735981

申请日：2016-06-23

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Ralf Seip ,  Evgeniy Leyvi ,  Balasundar Iyyavu Raju

IPC: A61M5/142 ,  B01F13/08 ,  A61B17/22 ,  A61M5/145 ,  B01F13/00 ,  A61N7/00 ,  A61M5/14

Abstract: An infusion system for sonothrombolysis treatment uses a syringe loaded with a microbubble solution and operated by a syringe pump to deliver the microbubble solution to a subject during sonothrombolysis treatment. To prevent the stratification of the microbubble solution in the barrel of the syringe during treatment, the barrel also contains a plurality of magnetic beads which are agitated into semi-random patterns of motion in the syringe chamber during the procedure. The magnetic beads are moved by magnetic attraction and repulsion from the moving magnets of a magnetic stirrer mounted in proximity to the syringe during treatment.