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    Registration of tissue slice image
    1.
    发明授权
    Registration of tissue slice image 有权

    公开(公告)号：US10043273B2

    公开(公告)日：2018-08-07

    申请号：US15029786

    申请日：2014-10-30

    Applicant: KONINKLIJKE PHILIPS N.V.

    Inventor： Jelte Peter Vink ,  Marinus Bastiaan Van Leeuwen

    IPC: G06K9/00 ,  G06T7/00 ,  G06T7/30 ,  G06T7/33 ,  G06T7/11

    Abstract: A method for registration of images of tissue slices comprises: receiving a first image (18a) of a first tissue slice (14a) and a second image (18b) of a second tissue slice (14b), both tissue slices being prepared from the same tissue block (10); determining an unreliable area (27) in the first image (14a) showing folded tissue (15); and registering the first image (14a) and the second image by registering an area of the first image and the second image outside of the unreliable area.

    Slide holding in digital pathology
    2.
    发明授权
    Slide holding in digital pathology 有权

    公开(公告)号：US11480779B2

    公开(公告)日：2022-10-25

    申请号：US16463636

    申请日：2017-11-28

    Applicant: KONINKLIJKE PHILIPS N.V.

    Inventor： Jelte Peter Vink ,  Johannes Hubertus Antonius Van De Rijdt ,  Nicole Catharina Elisabeth Haazen ,  Gerard Rudolf Riemens ,  Emilianus Henricus Anthonius Johannes Nuijten

    IPC: G02B21/34 ,  G01N35/00 ,  G02B21/36

    Abstract: The present invention relates to digital pathology. In order to provide an improved handling of probes in digital pathology, a slide-holder (10) for digital pathology is provided that comprises a tray basis (12), a plurality of mounting means (14) and a plurality of slide-holder registration points (16). The tray basis is configured to carry a plurality of slides (20) to be imaged by a digital pathology system, for which the tray basis provides a plurality of slide-receiving positions. The plurality of mounting means are arranged on the tray basis to mount the plurality of slides on the tray basis in a plurality of slide-receiving positions to image each slide in a separate imaging position. The slide-holder registration points comprise a plurality of interacting portions (22) that provide a mechanical registration of the tray basis with a digital pathology system for each of the imaging positions.

    Image processing
    3.
    发明授权
    Image processing 有权

    公开(公告)号：US09916515B2

    公开(公告)日：2018-03-13

    申请号：US14359187

    申请日：2012-11-07

    Applicant: KONINKLIJKE PHILIPS N.V.

    Inventor： Jelte Peter Vink ,  Marinus Bastiaan Van Leeuwen

    IPC: G06K9/46 ,  G06T7/00 ,  G06K9/00

    CPC classification number: G06K9/46 ,  G06K9/00127 ,  G06K2009/4666 ,  G06T7/0012 ,  G06T2207/20008 ,  G06T2207/30004

    Abstract: A system for processing an image comprises a region detector (1). The region detector comprises an artifact detector (7) for detecting a region comprising an artifact in the image. The system comprises a parameter determining unit (2) for determining a parameter, based on a portion of the image excluding the detected region. The system comprises an image processing module (3) for processing the image, using the derived parameter. The system comprises a display unit (5) for displaying the processed image with an indication of the detected region. The parameter determined by the parameter determining unit (2) can comprise a normalization parameter, and the image processing module (3) can be arranged for performing a normalization of the image according to the normalization parameter.

    Method and system for whole slide imaging
    8.
    发明授权
    Method and system for whole slide imaging 有权

    公开(公告)号：US12010467B2

    公开(公告)日：2024-06-11

    申请号：US17790291

    申请日：2020-12-24

    Applicant: KONINKLIJKE PHILIPS N.V.

    Inventor： Prarthana Shrestha ,  Jelte Peter Vink ,  Maarten Van Lierop ,  Gerardus Johannes Wilhelmus Van Den Braak ,  Mathijs Rem ,  Jeroen De Kleijn

    IPC: H04N9/67 ,  G02B21/36 ,  G06T7/90

    CPC classification number: H04N9/67 ,  G02B21/365 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/10056 ,  G06T2207/30024

    Abstract: A method (and system) is provided obtaining an adapted calibration transformation for whole slide imaging, wherein the adapted calibration transformation is for outputting the color of an empty area of the slide in a whole slide image, WSI, as a desired color. The method comprises first receiving a color target WSI in a device-dependent color space, wherein the color target WSI is a WSI of a color target from a scanner represented in the device-dependent color space. The color target contains at least a white patch and three (near) primary color patches. A calibration transformation is obtained for transforming the device-dependent color space to a device-independent color space. A chromatic adaptation transformation is derived using the color of the white patch in the device-dependent color space, the color of the empty (glass) area in the device-independent color space and the desired empty (glass) color in the target color space. An adapted calibration transformation is obtained by applying the chromatic adaptation transformation to the calibration transformation.

    Examining device for processing and analyzing an image
    9.
    发明授权
    Examining device for processing and analyzing an image 有权

    公开(公告)号：US11232565B2

    公开(公告)日：2022-01-25

    申请号：US15301518

    申请日：2015-03-31

    Applicant: KONINKLIJKE PHILIPS N.V.

    Inventor： Marinus Bastiaan Van Leeuwen ,  Jelte Peter Vink

    IPC: G06K9/00 ,  G06T7/00 ,  G06K9/32 ,  G06T7/73 ,  G06K9/46

    Abstract: The present invention relates to an examining device (1) for processing and analyzing an image of a bio sample, an examining method for processing and analyzing an image of a bio sample, a computer program element for controlling such device (1), and a corresponding computer readable medium. The examining device (1) for processing and analyzing an image of a bio sample comprises an interface unit, an image analyzing unit, and a display unit. The interface unit is configured to provide an image of a bio sample. The image analyzing unit is configured to indicate a region of interest in the image as reference region, to extract a characteristic of the reference region from the image and to analyze the image for alternative regions with a similar characteristic. The display unit is configured to display the result of the analysis for alternative regions with a similar characteristic.

    COMBINED SAMPLE EXAMINATIONS
    10.
    发明申请
    COMBINED SAMPLE EXAMINATIONS 审中-公开
    组合样本检查

    公开(公告)号：US20150262329A1

    公开(公告)日：2015-09-17

    申请号：US14432943

    申请日：2013-09-25

    Applicant: KONINKLIJKE PHILIPS N.V.

    Inventor： Jelte Peter Vink ,  Reinhold Wimberger-Friedl ,  Anja Van De Stolpe

    IPC: G06T3/40 ,  G06T7/00 ,  C12Q1/68

    CPC classification number: G06T3/40 ,  C12Q1/686 ,  G01N1/28 ,  G01N2001/282 ,  G01N2001/2886 ,  G06T2207/10004

    Abstract: The invention relates to a method and an apparatus (1000) for the examination of a sample, for example a slice of biological tissue (11) on a microscope slide (10). The method comprises the generation of an image (I) of the sample (11), the analysis of said image with respect to at least one sample-parameter, the selection of an image-ROI (region of interest) (RI) in said image (I), and the isolation of a corresponding sample-ROI (RS) from the sample (11). Molecular assays are then executed with the isolated sample-ROI (RS), and the data obtained from these assays are linked to the sample-parameter. The sample-parameter may particularly relate to the local amount of a particular cell-type or tissue-type.

    Abstract translation: 本发明涉及一种用于检查样本的方法和装置（1000），例如在显微镜载片（10）上的生物组织切片（11）。 该方法包括生成样本（11）的图像（I），相对于至少一个采样参数对所述图像的分析，所述图像的ROI（感兴趣区域）（RI）的选择在所述 图像（I），以及从样本（11）分离相应的样本 - ROI（RS）。 然后用分离的样品-RV（RS）进行分子测定，并且从这些测定获得的数据与样品参数相关联。 样品参数可以特别涉及特定细胞类型或组织型的局部量。

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