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公开(公告)号：US20230380976A1
公开(公告)日：2023-11-30
申请号：US18206661
申请日：2023-06-07
Applicant: KONINKLIJKE PHILIPS N.V.
CPC classification number: A61F2/30771 , A61C8/0006 , C12M23/02 , A61C2008/0046
Abstract: An object for altering cell behavior includes a surface part provided with at least one topography configured to modulate at least one of morphology, proliferation, biochemical functioning, differentiation, attachment, migration, signaling, or cell death of a cell population by physical stimulation, where the at least one topography includes a surface and multiple protrusions protruding from the surface, where the protrusions define multiple valleys between adjacent protrusions such that the adjacent protrusions do not touch, where each protrusion includes at least one protrusion element, where the top surface area of the at least one protrusion element has a complex shape comprising a combination of basic shapes, interconnected by one or more overlapping portions, the basic shapes including at least one of a circle, oval, triangle, square, rectangle, trapezoid, pentagon, hexagon, heptagon or octagon.
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公开(公告)号：US11744708B2
公开(公告)日：2023-09-05
申请号：US15998578
申请日：2017-02-16
Applicant: KONINKLIJKE PHILIPS N.V.
CPC classification number: A61F2/30771 , A61C8/0006 , C12M23/02 , A61C2008/0046 , A61F2002/3093 , A61F2002/30838 , A61F2002/30891 , A61F2310/00011 , A61F2310/00179
Abstract: The invention pertains to surface topographies which can be used to modulate the morphology, proliferation, biochemical functioning, differentiation, attachment, migration, signaling, and/or cell death of a cell population by physical stimulation. Such topographies can be applied in vitro and in vivo to modulate cell behavior. Specific examples include implants provided with a topography of the invention which regulates the immune response, or an implant which increases osteogenesis. The invention furthermore pertains to objects which are used in vitro to modulate cell behavior.
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