公开(公告)号：US20050106251A1

公开(公告)日：2005-05-19

申请号：US10484748

申请日：2002-07-18

Applicant: John Langridge ,  Wei Tian ,  Olayinka Lawal

Inventor： John Langridge ,  Wei Tian ,  Olayinka Lawal

IPC: A61K9/28 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/16 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61K47/44 ,  A61K47/46 ,  A61K9/22 ,  A61K9/26

CPC classification number: A61K9/2866 ,  A61K9/2846 ,  A61K9/2886 ,  A61K9/2893

Abstract: A controlled release dosage form comprising: (i) a tablet core comprising a pharmaceutically active ingredient and one or more pharmaceutically acceptable matrix forming polymers, (ii) a substantially insoluble casing extended over the tablet core covering between 25 to 99% of the surface area of the tablet core, like for example covering only the major surfaces like in FIG. 1 or on major surface and the sidewells like in FIG. 2, the casing resulting from electrostatic deposition of a powder comprising fusible particles onto the tablet core and fusing the particles to form a thin film such that the said electrostatic coated tablet releases the active ingredient with a release profile of active ingredient for 0 to at least 50% by weight release of active ingredient defined by the equations y=k*tn in which y is the fraction of active ingredient released, k is the kinetic constant, t is time, n is the release exponent and n is the range 0.70 to 1.0 i.e. an approximately zero order release profile.

Abstract translation: 控制释放剂型，其包含：（i）片芯，其包含药物活性成分和一种或多种药学上可接受的形成基质的聚合物，（ii）在所述片芯上延伸的基本不溶性外壳，覆盖所述表面积的25至99％ 片状芯，例如仅覆盖如图1所示的主表面。 1或在主表面和侧壁上，如图1所示。 2，由将可熔颗粒的粉末静电沉积到片芯上并将该颗粒融合以形成薄膜的外壳，使得所述静电包衣片剂以活性成分的释放曲线将活性成分释放至0至少至少 50重量％的由式y = k * t 定义的活性成分的释放，其中y是释放的活性成分的分数，k是动力学常数，t是时间，n是释放 指数，n是0.70到1.0的范围，即约为零阶释放曲线。