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公开(公告)号：US07077841B2
公开(公告)日：2006-07-18
申请号：US10017906
申请日：2001-12-14
申请人： John Gaiser , Scott West , David S Utley , David Huynh
发明人： John Gaiser , Scott West , David S Utley , David Huynh
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B1/00154 , A61M16/0493 , A61M25/02 , A61M2025/024
摘要： Systems and methods for treating a tissue region employ an expandable structure projecting beyond the distal end of a catheter tube. A distal tail projects beyond the far end of the basket assembly. The distal tail includes a guidewire lumen that accommodates passage of a guidewire without threading the guidewire through the catheter tube.
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公开(公告)号：US09125665B2
公开(公告)日：2015-09-08
申请号：US14055077
申请日：2013-10-16
申请人： David S. Utley , Scott West , John Gaiser
发明人： David S. Utley , Scott West , John Gaiser , Rachel Croft
IPC分类号： A61B18/18 , A61B18/14 , A61B1/00 , A61B8/12 , A61B18/02 , A61B17/00 , A61B18/00 , A61B18/04 , A61B18/20
CPC分类号： A61B18/1485 , A61B1/00087 , A61B8/12 , A61B18/02 , A61B18/1477 , A61B18/149 , A61B18/18 , A61B2017/00106 , A61B2018/00011 , A61B2018/00023 , A61B2018/00029 , A61B2018/00267 , A61B2018/005 , A61B2018/00553 , A61B2018/00642 , A61B2018/00702 , A61B2018/00791 , A61B2018/00982 , A61B2018/00994 , A61B2018/046 , A61B2018/1869 , A61B2018/2005
摘要： A sphincter tissue region is treated using a support structure sized for advancement into the anal canal. At least one electrode is carried by the structure. A mechanism is coupled to the electrode to move the electrode between a first position retracted in the support structure and a second position extended from the support structure through surface tissue to penetrate a subsurface tissue region at or near a sphincter in the anal canal. A cable is coupled to the electrode to conduct energy for application by the electrode to form a lesion in the subsurface tissue region.
摘要翻译： 括约肌组织区域使用尺寸适合进入肛管的支撑结构来治疗。 该结构承载至少一个电极。 机构耦合到电极以在缩回到支撑结构中的第一位置和从支撑结构延伸穿过表面组织的第二位置之间移动电极，以穿透肛管内的括约肌处或附近的下表面组织区域。 电缆耦合到电极以传导电极施加的能量，以在地下组织区域中形成病变。
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3.发明授权Operative devices that can be removably fitted on catheter bodies to treat tissue regions in the body 有权可拆卸地安装在导管体上以处理身体组织区域的手术装置公开(公告)号：US06544226B1
公开(公告)日：2003-04-08
申请号：US09524432
申请日：2000-03-13
申请人： John Gaiser , David S. Utley , Scott West
发明人： John Gaiser , David S. Utley , Scott West
IPC分类号： A61F712
CPC分类号： A61B1/00089 , A61B1/00101 , A61B1/00135 , A61B2017/00026 , A61B2017/00084 , A61B2017/00296 , A61B2017/00477 , A61B2018/00482 , A61B2018/00494 , A61B2018/00553 , A61B2018/00982 , A61B2018/143 , A61B2018/1475 , A61B2018/1495 , A61B2090/3782
摘要： A targeted tissue region in a body is treated by a tissue heating element attached to a carrier. The carrier is intended, in use, to be temporarily mounted to an exterior of a catheter body, such as an endoscope. The catheter body is deployed, with the carrier mounted on it, into the targeted tissue region. The tissue heating element is operated, e.g., to form one or more tissue lesions, after which the catheter body is retrieved from the targeted tissue region. The carrier can then be removed from the catheter body, allowing the catheter body to be subsequently used for another purpose.
摘要翻译： 身体中的靶组织区域被附着于载体的组织加热元件处理。 在使用中，载体被暂时安装到诸如内窥镜的导管体的外部。 将载体安装在其上的导管体部署到目标组织区域中。 组织加热元件操作，例如，以形成一个或多个组织损伤，之后从目标组织区域取回导管主体。 然后可以从导管主体移除载体，允许导管主体随后用于另一目的。
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公开(公告)号：US06464697B1
公开(公告)日：2002-10-15
申请号：US09304737
申请日：1999-05-04
申请人： Stuart Edwards , John Gaiser , David S Utley , Scott West , Jay Chin
发明人： Stuart Edwards , John Gaiser , David S Utley , Scott West , Jay Chin
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Systems and methods treat a tissue region. In one arrangement, the systems and methods deploy an electrode on a support structure in a tissue region at or near the cardia of the stomach. The support structure has a proximal region and a distal region. The proximal region is enlarged in comparison to the distal region, and the electrode is carried by the enlarged proximal surface. The systems and methods advance the electrode in a path to penetrate the tissue region and couple the electrode to a source of radio frequency energy to ohmically heat tissue and create a lesion in the tissue region. In another arrangement, the systems and methods treat abnormal epithelium tissue at or near the lower esophageal sphincter by bringing an array of surface electrodes into contact with abnormal epithelium tissue. The systems and methods couple the surface electrodes to a source of radio frequency energy to ohmically heat tissue and cause necrosis of the abnormal epithelium tissue.
摘要翻译： 系统和方法处理组织区域。 在一种布置中，系统和方法将电极部署在胃贲门处或附近的组织区域中的支撑结构上。 支撑结构具有近端区域和远侧区域。 近端区域与远侧区域相比放大，并且电极由扩大的近侧表面承载。 系统和方法使电极在路径中前进以穿透组织区域并将电极耦合到射频能量源以欧姆加热组织并在组织区域中产生损伤。 在另一种布置中，系统和方法通过使表面电极阵列与异常上皮组织接触来治疗食管下括约肌或其附近的异常上皮组织。 系统和方法将表面电极耦合到射频能量源以欧姆加热组织并引起异常上皮组织的坏死。
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5.发明授权Control systems for multiple electrode arrays to create lesions in tissue regions at or near a sphincter 有权用于多个电极阵列的控制系统以在括约肌处或附近的组织区域中产生损伤公开(公告)号：US06355031B1
公开(公告)日：2002-03-12
申请号：US09304733
申请日：1999-05-04
申请人： Stuart Edwards , John Gaiser , David S Utley , Scott West , Jay Qin
发明人： Stuart Edwards , John Gaiser , David S Utley , Scott West , Jay Qin
IPC分类号： A61B1818
CPC分类号： A61B18/1206 , A61B18/12 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00494 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Multiple electrodes are coupled together in monopolar or bipolar arrays to form lesion patterns in tissue regions at or near a sphincter. A controller couples the electrodes to a generator so that a single power channel serves more than a single electrode.
摘要翻译： 多个电极以单极或双极阵列耦合在一起，以在括约肌处或附近的组织区域中形成病变图案。 控制器将电极耦合到发生器，使得单个功率通道服务于单个电极。
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公开(公告)号：US07507238B2
公开(公告)日：2009-03-24
申请号：US11420719
申请日：2006-05-26
申请人： Stuart D Edwards , John Gaiser , David S Utley , Scott West , Jay Qin
发明人： Stuart D Edwards , John Gaiser , David S Utley , Scott West , Jay Qin
CPC分类号： A61B18/1492 , A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Methods of accessing and ablating abnormal epithelium tissue in an alimentary canal are provided. The methods can include steps of (i) inserting a vacuum source comprising one or more suction ports into an alimentary canal; (ii) inserting an operative element comprising a conduit for a tissue ablation source into the alimentary canal; (iii) positioning the vacuum source and the operative element proximate a portion of the alimentary canal having a site of abnormal tissue to be ablated; (iv) applying a vacuum to at least one of each suction port to draw the tissue against the operative element; and (v) applying the tissue ablation source to the tissue through the conduit to effect tissue ablation.
摘要翻译： 提供了在消化道中获取和消融异常上皮组织的方法。 所述方法可以包括以下步骤：（i）将包括一个或多个吸入口的真空源插入消化道; （ii）将包括用于组织消融源的导管的操作元件插入消化道中; （iii）将真空源和操作元件定位在具有要消融的异常组织部位的消化道的一部分附近; （iv）向每个抽吸口中的至少一个施加真空以将组织拉向操作元件; 和（v）通过导管将组织消融源施加到组织以实现组织消融。
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公开(公告)号：US06402744B2
公开(公告)日：2002-06-11
申请号：US09304750
申请日：1999-05-04
申请人： Stuart D Edwards , John Gaiser , David S Utley , Scott West , Jay Qin
发明人： Stuart D Edwards , John Gaiser , David S Utley , Scott West , Jay Qin
IPC分类号： A61B1818
CPC分类号： A61B18/1206 , A61B18/12 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Systems and methods manipulate a support structure to form a composite lesion in a tissue region at or near a sphincter. The support structure carries an array of electrodes attachable to a source of energy capable of heating tissue when transmitted by the electrodes. The systems and methods advance the electrodes to penetrate the tissue region and form, when the energy is transmitted, a first pattern of lesions. The systems and methods retract the electrodes, and shift the position of the electrodes, either rotationally, or axially, or both rotationally and axially. The systems and methods advance the electrodes a second time to form, when the energy is transmitted, a second pattern of lesions either rotationally or axially or both rotationally and axially shifted from the first pattern of lesions. The first and second patterns of lesion together comprise the composite lesion.
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公开(公告)号：US06562034B2
公开(公告)日：2003-05-13
申请号：US10046637
申请日：2002-01-14
申请人： Stuart D Edwards , John Gaiser , David S Utley , Scott West , Jay Qin
发明人： Stuart D Edwards , John Gaiser , David S Utley , Scott West , Jay Qin
IPC分类号： A61B1818
CPC分类号： A61B18/1485 , A61B18/1477 , A61B18/1492 , A61B2017/00867 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00553 , A61B2018/00738 , A61B2018/046 , A61B2018/1425 , A61B2090/036 , C08L2201/12
摘要： Improved electrode assemblies for treating a tissue region at or near a sphincter comprise a support structure and an electrode carried by the support structure for advancement in a path to penetrate the tissue region. In one arrangement, the electrode has a non-cylindrical cross section selected to resist deflection when advanced to penetrate the tissue region. In another arrangement, the electrode includes a tissue stop to resist tissue penetration beyond a selected depth. In another arrangement, the electrode includes a proximal portion formed from a first material and a distal tissue penetrating portion formed of a second material different than the first material. The first material can comprise, e.g., stainless steel, and the second material can comprise, e.g., nickel titanium.
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9.发明授权公开(公告)号：US06423058B1
公开(公告)日：2002-07-23
申请号：US09304770
申请日：1999-05-04
申请人： Stuart D Edwards , John Gaiser , David S Utley , Scott West , Jay Qin
发明人： Stuart D Edwards , John Gaiser , David S Utley , Scott West , Jay Qin
IPC分类号： A61B1818
CPC分类号： A61B18/1206 , A61B18/12 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Assemblies for treating a tissue region at or near a sphincter have a support structure with a distal end and an electrode carried by the support structure for contact with the tissue region. A lumen in the support structure accommodates passage of a body through the support structure and beyond the distal end of the support structure. The body can comprise a guide wire to guide deployment of the support structure, or an endoscope to permit visualization of the support structure from beyond the distal end of the support structure.
摘要翻译： 用于治疗括约肌处或附近的组织区域的组件具有支撑结构，其具有远端和由支撑结构承载的用于与组织区域接触的电极。 支撑结构中的内腔容纳主体通过支撑结构并超出支撑结构的远端的通道。 主体可以包括引导线以引导支撑结构的展开，或内窥镜，以允许从支撑结构的远端超出支撑结构的可视化。
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公开(公告)号：US20060149185A1
公开(公告)日：2006-07-06
申请号：US11366650
申请日：2006-03-02
申请人： John Gaiser , Scott West , David Utley , David Huynh
发明人： John Gaiser , Scott West , David Utley , David Huynh
IPC分类号： A61J7/00
CPC分类号： A61B18/1492 , A61B1/00154 , A61M16/0493 , A61M25/02 , A61M2025/024
摘要： Systems and methods for treating a tissue region employ an expandable structure projecting beyond the distal end of a catheter tube. A distal tail projects beyond the far end of the basket assembly. The distal tail includes a guidewire lumen that accommodates passage of a guidewire without threading the guidewire through the catheter tube.
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