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1.发明申请Benzofused heterozryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use 审中-公开可用作治疗剂的噻吩并吡啶的苯并稠合异嗪酰胺衍生物，包含它们的药物组合物及其使用方法公开(公告)号：US20060079548A1
公开(公告)日：2006-04-13
申请号：US11256477
申请日：2005-10-21
申请人： Michael Collins , Stephan Cripps , Judith Deal , Robert Kania , Jihong Lou , Mingying He , Cynthia Palmer , William Romines , Ru Zhou
发明人： Michael Collins , Stephan Cripps , Judith Deal , Robert Kania , Jihong Lou , Mingying He , Cynthia Palmer , William Romines , Ru Zhou
IPC分类号： A61K31/4743 , C07D498/02
CPC分类号： A61K31/4743 , C07D495/04
摘要： The invention relates to compounds represented by the formula I and to prodrugs or metabolites thereof, or pharmaceutically acceptable salts or solvates of said compounds, said prodrugs, and said metabolites, wherein Z, Y, R11 and R14, R15, R16, and R17 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
摘要翻译： 本发明涉及由式I表示的化合物及其前体药物或代谢物，或所述化合物，所述前药和所述代谢产物的药学上可接受的盐或溶剂合物，其中Z，Y，R 11和R R 15，R 16，R 16和R 17如本文所定义。 本发明还涉及含有式I化合物的药物组合物和通过施用式I化合物来治疗哺乳动物中过度增殖性疾病的方法。
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2.发明申请Napthalene carboxamides and their derivatives useful as new anti-angiogenic agents 审中-公开萘甲酰胺及其衍生物可用作新的抗血管生成剂公开(公告)号：US20050070508A1
公开(公告)日：2005-03-31
申请号：US10924528
申请日：2004-08-23
申请人： Jihong Lou , Robert Kania , Mingying He , Ru Zhou
发明人： Jihong Lou , Robert Kania , Mingying He , Ru Zhou
IPC分类号： A61P35/00 , C07D213/68 , C07D215/20 , C07D239/34 , C07D239/42 , C07D495/04 , A61K31/655 , A61K31/165 , A61K31/519
CPC分类号： C07D239/34 , C07D213/68 , C07D215/20 , C07D239/42 , C07D495/04
摘要： The invention relates to compounds represented by Formula (I): and to prodrugs thereof, pharmaceutically acceptable salts or solvates of said compounds or said prodrugs, wherein each of R1a-d, R2a-b, R3, and X1 are defined herein. The invention also relates to pharmaceutical compositions containing the compounds of Formula (I) and to methods of treating hyperproliferative disorders in a mammal by administering compounds of Formula (I).
摘要翻译： 本发明涉及由式（I）表示的化合物及其前药，所述化合物或所述前药的药学上可接受的盐或溶剂合物，其中R 1a-d，R 2a-b，R 3， ，X 1如本文所定义。 本发明还涉及含有式（I）化合物的药物组合物以及通过施用式（I）的化合物来治疗哺乳动物的过度增殖性疾病的方法。
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公开(公告)号：US20080280875A1
公开(公告)日：2008-11-13
申请号：US11746359
申请日：2007-05-09
申请人： Hao Bai , Simon Bailey , Dilip Ramakant Bhumralkar , Feng C. Bi , Fengli Guo , Mingying He , Paul Stuart Humphries , Anthony Lai Ling , Jihong Lou , Seiji Nukul , Ru Zhou
发明人： Hao Bai , Simon Bailey , Dilip Ramakant Bhumralkar , Feng C. Bi , Fengli Guo , Mingying He , Paul Stuart Humphries , Anthony Lai Ling , Jihong Lou , Seiji Nukul , Ru Zhou
IPC分类号： A61K31/497 , A61K31/4155 , A61K31/4192 , A61K31/42 , A61K31/4245 , A61K31/426 , A61K31/50 , A61K31/5375 , C07D205/02 , C07D271/06 , C07D261/02 , C07D249/04 , C07D241/02 , C07D239/02 , C07D237/02 , C07D231/02 , C07D221/00 , C07D213/02 , C07D295/00 , C07D285/12 , C07D277/02 , A61P3/00 , A61K31/505 , A61K31/433 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/4965
CPC分类号： C07D405/14 , C07D401/12 , C07D405/12
摘要： The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein: Ring A is (4-12)-membered heterocyclyl; Ring B is a fused benzene ring selected from the group consisting of: Ring A, ring B, ring C, R1, R1a, R2, R3, R4, L2, n, t, w, and z are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of glucokinase, the method comprising administering to a mammal an effective amount of a compound of formula (I).
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐或溶剂化物，其中：环A是（4-12） - 杂环基; 环B是选自以下的稠合苯环：环A，环B，环C，R 1，R 1a，R 2， R S，R 3，R 4，L 2，n，t，w和z如说明书中所定义。 本发明还涉及包含式（I）化合物的药物组合物和治疗由葡萄糖激酶调节介导的病症的方法，所述方法包括向哺乳动物施用有效量的式（I）化合物。
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公开(公告)号：US08119624B2
公开(公告)日：2012-02-21
申请号：US12913059
申请日：2010-10-27
申请人： Hao Bai , Simon Bailey , Dilip Ramakant Bhumralkar , Feng C. Bi , Fengli Guo , Mingying He , Paul Stuart Humphries , Anthony Lai Ling , Jihong Lou , Seiji Nukui , Ru Zhou
发明人： Hao Bai , Simon Bailey , Dilip Ramakant Bhumralkar , Feng C. Bi , Fengli Guo , Mingying He , Paul Stuart Humphries , Anthony Lai Ling , Jihong Lou , Seiji Nukui , Ru Zhou
IPC分类号： A61K31/44 , A61K31/415 , A61K31/47 , A61K31/42 , A61K31/397 , A61K31/4965 , A61K31/41 , C07D215/00 , C07D401/00 , C07D413/00 , C07D405/00 , C07D403/00 , C07D231/00
CPC分类号： C07D405/14 , C07D401/12 , C07D405/12
摘要： The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein:Ring A is (4-12)-membered heterocyclyl;Ring B is a fused benzene ring selected from the group consisting of: Ring A, ring B, ring C, R1, R1a, R2, R3, R4, L2, n, t, w, and z are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of glucokinase, the method comprising administering to a mammal an effective amount of a compound of formula (I).
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐或溶剂化物，其中：环A是（4-12） - 杂环基; 环B是选自环A，环B，环C，R 1，R 1a，R 2，R 3，R 4，L 2，n，t，w和z的稠合苯环如说明书中所定义。 本发明还涉及包含式（I）化合物的药物组合物和治疗由葡萄糖激酶调节介导的病症的方法，所述方法包括向哺乳动物施用有效量的式（I）化合物。
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公开(公告)号：US07842713B2
公开(公告)日：2010-11-30
申请号：US11746359
申请日：2007-05-09
申请人： Hao Bai , Simon Bailey , Dilip Ramakant Bhumralkar , Feng C. Bi , Fengli Guo , Mingying He , Paul Stuart Humphries , Anthony Lai Ling , Jihong Lou , Seiji Nukui , Ru Zhou
发明人： Hao Bai , Simon Bailey , Dilip Ramakant Bhumralkar , Feng C. Bi , Fengli Guo , Mingying He , Paul Stuart Humphries , Anthony Lai Ling , Jihong Lou , Seiji Nukui , Ru Zhou
IPC分类号： A61K31/4155 , C07D231/10
CPC分类号： C07D405/14 , C07D401/12 , C07D405/12
摘要： The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein:Ring A is (4-12)-membered heterocyclyl;Ring B is a fused benzene ring selected from the group consisting of: Ring A, ring B, ring C, R1, R1a, R2, R3, R4, L2, n, t, w, and z are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of glucokinase, the method comprising administering to a mammal an effective amount of a compound of formula (I).
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐或溶剂化物，其中：环A是（4-12） - 杂环基; 环B是选自环A，环B，环C，R 1，R 1a，R 2，R 3，R 4，L 2，n，t，w和z的稠合苯环如说明书中所定义。 本发明还涉及包含式（I）化合物的药物组合物和治疗由葡萄糖激酶调节介导的病症的方法，所述方法包括向哺乳动物施用有效量的式（I）化合物。
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公开(公告)号：US07045528B2
公开(公告)日：2006-05-16
申请号：US10796226
申请日：2004-03-09
申请人： Michael Collins , Stephan Cripps , Judith Deal , Robert Steven Kania , Jihong Lou , Mingying He , Cynthia Louise Palmer , William Henry Romines, III , Ru Zhou
发明人： Michael Collins , Stephan Cripps , Judith Deal , Robert Steven Kania , Jihong Lou , Mingying He , Cynthia Louise Palmer , William Henry Romines, III , Ru Zhou
IPC分类号： A61K31/4365 , C07D495/04
CPC分类号： A61K31/4743 , C07D495/04
摘要： The invention relates to compounds represented by the formula I and to prodrugs or metabolites thereof, or pharmaceutically acceptable salts or solvates of said compounds, said prodrugs, and said metabolites, wherein Z, Y, R11 and R14, R15, R16, and R17 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
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7.发明授权Indolyl-urea derivatives of thienopyridines useful as antiangiogenic agents, and methods for their use 失效可用作抗血管生成剂的噻吩并吡啶的吲哚基 - 脲衍生物及其用途公开(公告)号：US06833456B2
公开(公告)日：2004-12-21
申请号：US10371337
申请日：2003-02-21
申请人： William Henry Romines, III , Robert Steven Kania , Jihong Lou , Stephan Cripps , Ru Zhou , Mingying He
发明人： William Henry Romines, III , Robert Steven Kania , Jihong Lou , Stephan Cripps , Ru Zhou , Mingying He
IPC分类号： C07D49504
CPC分类号： C07D495/04
摘要： The invention relates to compounds represented by the formula I and to prodrugs thereof, pharmaceutically acceptable salts or solvates of said compounds or said prodrugs, wherein X, R1 and R11 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
摘要翻译： 本发明涉及由式I表示的化合物及其前药，所述化合物或所述前药的药学上可接受的盐或溶剂合物，其中X，R 1和R 11如本文所定义。 本发明还涉及含有式I化合物的药物组合物和通过施用式I化合物来治疗哺乳动物中过度增殖性疾病的方法。
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公开(公告)号：US20110039821A1
公开(公告)日：2011-02-17
申请号：US12913059
申请日：2010-10-27
申请人： Hao Bai , Simon Bailey , Dilip Ramakant Bhumralkar , Feng C. Bi , Fengli Guo , Mingying He , Paul Stuart Humphries , Anthony Lai Ling , Jihong Lou , Seiji Nukui , Ru Zhou
发明人： Hao Bai , Simon Bailey , Dilip Ramakant Bhumralkar , Feng C. Bi , Fengli Guo , Mingying He , Paul Stuart Humphries , Anthony Lai Ling , Jihong Lou , Seiji Nukui , Ru Zhou
IPC分类号： A61K31/397 , C07D405/12 , A61K31/443 , C07D401/14 , A61K31/4155 , C07D403/14 , C07D401/12 , A61K31/4709 , A61K31/4439 , C07D413/12 , A61K31/423 , C07D403/12 , A61K31/497 , A61K31/4192 , A61P3/00
CPC分类号： C07D405/14 , C07D401/12 , C07D405/12
摘要： The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein: Ring A is (4-12)-membered heterocyclyl; Ring B is a fused benzene ring selected from the group consisting of: Ring A, ring B, ring C, R1, R1a, R2, R3, R4, L2, n, t, w, and z are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of glucokinase, the method comprising administering to a mammal an effective amount of a compound of formula (I).
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐或溶剂化物，其中：环A是（4-12） - 杂环基; 环B是选自环A，环B，环C，R 1，R 1a，R 2，R 3，R 4，L 2，n，t，w和z的稠合苯环如说明书中所定义。 本发明还涉及包含式（I）化合物的药物组合物和治疗由葡萄糖激酶调节介导的病症的方法，所述方法包括向哺乳动物施用有效量的式（I）化合物。
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9.发明授权Benzofused heterozryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use 失效可用作治疗剂的噻吩并吡啶的苯并稠合异嗪酰胺衍生物，包含它们的药物组合物及其使用方法公开(公告)号：US06869962B2
公开(公告)日：2005-03-22
申请号：US10460010
申请日：2003-06-11
申请人： Michael Collins , Stephan Cripps , Judith Deal , Robert Steven Kania , Jihong Lou , Mingying He , Cynthia Louise Palmer , William Henry Romines, III , Ru Zhou
发明人： Michael Collins , Stephan Cripps , Judith Deal , Robert Steven Kania , Jihong Lou , Mingying He , Cynthia Louise Palmer , William Henry Romines, III , Ru Zhou
IPC分类号： A61K31/4365 , A61K31/444 , A61K31/506 , A61K31/5377 , A61P1/18 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P13/08 , A61P15/08 , A61P17/00 , A61P17/06 , A61P17/12 , A61P25/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D495/04 , C07D409/14
CPC分类号： A61K31/4743 , C07D495/04
摘要： The invention relates to compounds represented by the formula I and to prodrugs or metabolites thereof, or pharmaceutically acceptable salts or solvates of said compounds, said prodrugs, and said metabolites, wherein Z, Y, R11 and R14, R15, R16, and R17 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
摘要翻译： 本发明涉及由式I表示的化合物及其前体药物或代谢物，或所述化合物，所述前药和所述代谢产物的药学上可接受的盐或溶剂合物，其中Z，Y，R 11和R 14， R 16，R 17和R 17如本文所定义。 本发明还涉及含有式I化合物的药物组合物和通过施用式I化合物来治疗哺乳动物中过度增殖性疾病的方法。
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10.发明授权Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis 失效杀虫病毒化合物和组合物，其药物用途和用于其合成的材料公开(公告)号：US06995142B2
公开(公告)日：2006-02-07
申请号：US10289982
申请日：2002-11-06
申请人： Peter Scott Dragovich , Stephen Evan Webber , Thomas Jay Prins , Ru Zhou , Joseph Timothy Marakovits , Theodore O. Johnson, Jr.
发明人： Peter Scott Dragovich , Stephen Evan Webber , Thomas Jay Prins , Ru Zhou , Joseph Timothy Marakovits , Theodore O. Johnson, Jr.
IPC分类号： C07K5/06
CPC分类号： C07D207/26 , A61K38/00 , C07D261/18 , C07D413/12 , C07K5/0205 , Y02A50/463 , Y02A50/465
摘要： Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.
摘要翻译： 肽和肽模拟化合物的化学式为：化学式id =“CHEM-US-00001”num =“000
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