公开(公告)号：US20110189088A1

公开(公告)日：2011-08-04

申请号：US12977957

申请日：2010-12-23

申请人： Jide Xu ,  Nathaniel G. Butlin ,  Darren Magda

发明人： Jide Xu ,  Nathaniel G. Butlin ,  Darren Magda

IPC分类号： A61K51/04 ,  C07F15/02 ,  C07F7/00 ,  C07F5/00 ,  C07H23/00 ,  C07K16/00

CPC分类号： C07D213/89 ,  C07D487/22 ,  C07D498/22

摘要： The invention provides compounds such as chelating agents useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.

摘要翻译： 本发明提供了可用于螯合金属离子，特别是放射性核素的化合物，例如螯合剂，以提供金属离子络合物。 本发明还提供了使用本发明的化合物和复合物的方法，例如在治疗和诊断应用中。

公开(公告)号：US20120214253A1

公开(公告)日：2012-08-23

申请号：US13392506

申请日：2010-08-24

申请人： Nathaniel G. Butlin ,  Kenneth N. Raymond ,  Jide Xu ,  Anthony D'Aleo

发明人： Nathaniel G. Butlin ,  Kenneth N. Raymond ,  Jide Xu ,  Anthony D'Aleo

IPC分类号： G01N21/76 ,  C07F5/00 ,  C07D401/14 ,  C07D471/22

CPC分类号： G01N33/582 ,  C07D487/18 ,  C07D498/22 ,  G01N21/6428 ,  G01N33/533 ,  G01N2021/6432 ,  G01N2021/6439

摘要： The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds comprise hydroxypyridinonyl moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability.

摘要翻译： 本发明提供了一类新的大环化合物以及在金属（例如镧系元素）离子和本发明的化合物之间形成的络合物。 优选的配合物在水性介质中表现出高稳定性以及镧系元素离子发光的高量子产率，而不需要第二活化剂。 优选的化合物在其大环结构内包含羟基吡啶基部分，其特征在于与多种多肽如抗体和蛋白质具有惊人的低，非特异性结合以及高动力学稳定性。

公开(公告)号：US20080213780A1

公开(公告)日：2008-09-04

申请号：US12020470

申请日：2008-01-25

申请人： Nathaniel G. Butlin ,  Todd M. Corneillie ,  Jide Xu

发明人： Nathaniel G. Butlin ,  Todd M. Corneillie ,  Jide Xu

IPC分类号： C12Q1/68 ,  C07D259/00 ,  G01N21/76 ,  C09K11/06 ,  C12N1/00 ,  C12Q1/02

CPC分类号： C07D487/18 ,  A61K49/0043 ,  A61K49/0052 ,  C09B11/24 ,  C09B57/10 ,  C09K11/06 ,  C09K2211/145 ,  C09K2211/1466 ,  C09K2211/182 ,  G01N33/533

摘要： The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.

摘要翻译： 本发明提供了一类新的大环化合物以及在金属（例如镧系元素）离子和本发明的化合物之间形成的络合物。 优选的配合物在水性介质中表现出高稳定性以及镧系元素离子发光的高量子产率，而不需要第二活化剂。 优选的化合物在其大环结构内掺入羟基间苯二酰胺部分，其特征在于与各种多肽例如抗体和蛋白质以及高动力学稳定性令人惊奇的低非特异性结合。 这些特征将它们与已知的开放结构的配体区分开来。

公开(公告)号：US09273059B2

公开(公告)日：2016-03-01

申请号：US13392506

申请日：2010-08-24

申请人： Nathaniel G. Butlin ,  Kenneth N. Raymond ,  Jide Xu ,  Anthony D'Aleo

发明人： Nathaniel G. Butlin ,  Kenneth N. Raymond ,  Jide Xu ,  Anthony D'Aleo

IPC分类号： G01N21/76 ,  C07D487/18 ,  C07D498/22 ,  G01N33/533

CPC分类号： G01N33/582 ,  C07D487/18 ,  C07D498/22 ,  G01N21/6428 ,  G01N33/533 ,  G01N2021/6432 ,  G01N2021/6439

摘要： The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds comprise hydroxypyridinonyl moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability.

摘要翻译： 本发明提供了一类新的大环化合物以及在金属（例如镧系元素）离子和本发明的化合物之间形成的络合物。 优选的配合物在水性介质中表现出高稳定性以及镧系元素离子发光的高量子产率，而不需要第二活化剂。 优选的化合物在其大环结构内包含羟基吡啶基部分，其特征在于与多种多肽如抗体和蛋白质具有惊人的低，非特异性结合以及高动力学稳定性。

公开(公告)号：US08507199B2

公开(公告)日：2013-08-13

申请号：US12521910

申请日：2008-01-25

申请人： Nathaniel G. Butlin ,  Todd M. Corneillie ,  Jide Xu

发明人： Nathaniel G. Butlin ,  Todd M. Corneillie ,  Jide Xu

IPC分类号： C12Q1/68 ,  C07D259/00

CPC分类号： C07D487/18 ,  A61K49/0043 ,  A61K49/0052 ,  C09B11/24 ,  C09B57/10 ,  C09K11/06 ,  C09K2211/145 ,  C09K2211/1466 ,  C09K2211/182 ,  G01N33/533

摘要： The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.

摘要翻译： 本发明提供了一类新的大环化合物以及在金属（例如镧系元素）离子和本发明的化合物之间形成的络合物。 优选的配合物在水性介质中表现出高稳定性以及镧系元素离子发光的高量子产率，而不需要第二活化剂。 优选的化合物在其大环结构内掺入羟基间苯二酰胺部分，其特征在于与各种多肽例如抗体和蛋白质以及高动力学稳定性令人惊奇的低非特异性结合。 这些特征将它们与已知的开放结构的配体区分开来。

公开(公告)号：US20100167289A1

公开(公告)日：2010-07-01

申请号：US12521910

申请日：2008-01-25

申请人： Nathaniel G. Butlin ,  Todd M. Corneillie ,  Jide Xu

发明人： Nathaniel G. Butlin ,  Todd M. Corneillie ,  Jide Xu

IPC分类号： C12Q1/68 ,  C07D487/18 ,  C07H19/00

CPC分类号： C07D487/18 ,  A61K49/0043 ,  A61K49/0052 ,  C09B11/24 ,  C09B57/10 ,  C09K11/06 ,  C09K2211/145 ,  C09K2211/1466 ,  C09K2211/182 ,  G01N33/533

摘要： The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.

摘要翻译： 本发明提供了一类新的大环化合物以及在金属（例如镧系元素）离子和本发明的化合物之间形成的络合物。 优选的配合物在水性介质中表现出高稳定性以及镧系元素离子发光的高量子产率，而不需要第二活化剂。 优选的化合物在其大环结构内掺入羟基间苯二酰胺部分，其特征在于与各种多肽例如抗体和蛋白质以及高动力学稳定性令人惊奇的低非特异性结合。 这些特征将它们与已知的开放结构的配体区分开来。

公开(公告)号：US20110028863A1

公开(公告)日：2011-02-03

申请号：US12905739

申请日：2010-10-15

申请人： Nathaniel G. Butlin ,  Charles A. Martin

发明人： Nathaniel G. Butlin ,  Charles A. Martin

IPC分类号： A61B5/00

CPC分类号： A61B10/0051 ,  A61B10/0096

摘要： A sample collection container adapted to be connected to, and disconnected from, a sample collection adapter and a sample collection container cap. The sample collection adapter has a downward sloping interior surface that provides a free-flowing path for samples provided by a subject to the sample collection container. The sample collection adapter may have a three-dimensional rim that is curved in two different non-parallel planes.

摘要翻译： 样品收集容器，其适于连接到样品收集适配器和样品收集容器盖上并与其分离。 样品采集适配器具有向下倾斜的内表面，其提供由受试者提供给样品采集容器的样品的自由流动路径。 样品采集适配器可以具有在两个不同的非平行平面中弯曲的三维边缘。

公开(公告)号：US07267994B2

公开(公告)日：2007-09-11

申请号：US10854735

申请日：2004-05-24

申请人： Claude F. Meares ,  Carlito B. Lebrilla ,  Nathaniel G. Butlin ,  Sarah M. Cheal ,  Todd M. Corneillie ,  Susan Lee ,  Paul A. Whetstone ,  Nicolas L. Young

发明人： Claude F. Meares ,  Carlito B. Lebrilla ,  Nathaniel G. Butlin ,  Sarah M. Cheal ,  Todd M. Corneillie ,  Susan Lee ,  Paul A. Whetstone ,  Nicolas L. Young

IPC分类号： G01N33/532 ,  G01N33/24 ,  G01N24/00 ,  G01N33/53 ,  C07K1/14 ,  C07D257/02

CPC分类号： G01N33/582 ,  C12Q1/6886 ,  G01N2458/40 ,  Y10S435/81 ,  Y10S435/973 ,  Y10S435/975 ,  Y10T436/145555 ,  Y10T436/24

摘要： The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules. More particularly, the invention provides Element Coded Affinity Tags comprising a metal chelate and a metal ion and methods of using the tags to detect, analyze, and identify biomolecules including polypeptides, nucleic acids, lipids, and polysaccharides.

摘要翻译： 本发明提供用于检测，分析和鉴定生物分子的组合物和方法。 更具体地，本发明提供了包含金属螯合物和金属离子的元件编码亲和标签，以及使用标签来检测，分析和鉴定包括多肽，核酸，脂质和多糖的生物分子的方法。

公开(公告)号：US08647285B2

公开(公告)日：2014-02-11

申请号：US12905739

申请日：2010-10-15

申请人： Nathaniel G. Butlin ,  Charles A. Martin

发明人： Nathaniel G. Butlin ,  Charles A. Martin

IPC分类号： A61B5/00 ,  B65D81/00

CPC分类号： A61B10/0051 ,  A61B10/0096

摘要： A sample collection container adapted to be connected to, and disconnected from, a sample collection adapter and a sample collection container cap. The sample collection adapter has a downward sloping interior surface that provides a free-flowing path for samples provided by a subject to the sample collection container. The sample collection adapter may have a three-dimensional rim that is curved in two different non-parallel planes.

摘要翻译： 样品收集容器，其适于连接到样品收集适配器和样品收集容器盖上并与其分离。 样品采集适配器具有向下倾斜的内表面，其提供由受试者提供给样品采集容器的样品的自由流动路径。 样品采集适配器可以具有在两个不同的非平行平面中弯曲的三维边缘。

公开(公告)号：US20100151591A1

公开(公告)日：2010-06-17

申请号：US12611035

申请日：2009-11-02

申请人： Nathaniel G. Butlin ,  Larry Mimms

发明人： Nathaniel G. Butlin ,  Larry Mimms

IPC分类号： G01N33/53

CPC分类号： G01N33/542 ,  G01N2458/40

摘要： The present invention provides compositions and methods for detecting the presence of an analyte in a sample. Exemplary compositions comprise macrocyclic lanthanide complexes that are useful for transferring energy to an energy transfer acceptor to indicate the presence of the analyte. The compositions and methods are particularly suited for detecting antibodies in a sample.

摘要翻译： 本发明提供了用于检测样品中分析物的存在的组合物和方法。 示例性组合物包含可用于将能量转移到能量转移受体以指示分析物的存在的大环镧系元素络合物。 组合物和方法特别适用于检测样品中的抗体。