公开(公告)号：US10308686B2

公开(公告)日：2019-06-04

申请号：US16205500

申请日：2018-11-30

申请人： Jianfeng Cai ,  Youhong Niu ,  Haifan Wu ,  Shruti Padhee

发明人： Jianfeng Cai ,  Youhong Niu ,  Haifan Wu ,  Shruti Padhee

IPC分类号： C07K7/02 ,  C07K7/56 ,  A61K47/54 ,  C07K1/16 ,  C07K1/10 ,  C07K7/64 ,  C07K7/06 ,  A61K49/00 ,  A61K45/06 ,  A61K38/12 ,  A61K38/08 ,  G01N33/569 ,  A61K38/00

摘要： The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

公开(公告)号：US20150274782A1

公开(公告)日：2015-10-01

申请号：US14374018

申请日：2013-01-23

申请人： Jianfeng Cai ,  Youhong Niu ,  Haifan Wu ,  Shruti Padhee

发明人： Jianfeng Cai ,  Youhong Niu ,  Haifan Wu ,  Shruti Padhee

IPC分类号： C07K7/64 ,  A61K45/06 ,  A61K49/00 ,  C07K7/06

CPC分类号： C07K7/56 ,  A61K38/00 ,  A61K38/08 ,  A61K38/12 ,  A61K45/06 ,  A61K47/543 ,  A61K49/0056 ,  C07K1/10 ,  C07K1/16 ,  C07K7/06 ,  C07K7/64 ,  G01N33/569 ,  Y02A50/40 ,  Y02A50/401 ,  Y02A50/402 ,  Y02A50/411 ,  Y02A50/469 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/478 ,  Y02A50/479 ,  Y02A50/481 ,  Y02A50/483 ,  Y02A50/52 ,  Y02A50/56 ,  Y02A50/59

摘要： The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

摘要翻译： 本发明涉及一种称为γ-AA肽的新型抗微生物剂。 本发明提供各种类型的γ-AA肽，例如线性γ-AA肽，环状γ-AA肽和脂质化的γ-AA肽。 本发明的γ-AA肽被设计成在稳定和无毒的同时发挥抗菌活性。 γ-AA肽也似乎不会导致处理微生物中微生物抗性的发展。 因此，所公开的γ-AA肽可用于治疗与病原微生物相关的各种医学病症。

公开(公告)号：US10144764B2

公开(公告)日：2018-12-04

申请号：US15292162

申请日：2016-10-13

申请人： Jianfeng Cai ,  Youhong Niu ,  Haifan Wu ,  Shruti Padhee

发明人： Jianfeng Cai ,  Youhong Niu ,  Haifan Wu ,  Shruti Padhee

IPC分类号： A61K38/00 ,  C07K7/56 ,  A61K38/08 ,  A61K38/12 ,  G01N33/569 ,  A61K45/06 ,  A61K49/00 ,  C07K7/06 ,  C07K7/64 ,  C07K1/10 ,  C07K1/16 ,  A61K47/54

摘要： The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

公开(公告)号：US09499587B2

公开(公告)日：2016-11-22

申请号：US14374018

申请日：2013-01-23

申请人： Jianfeng Cai ,  Youhong Niu ,  Haifan Wu ,  Shruti Padhee

发明人： Jianfeng Cai ,  Youhong Niu ,  Haifan Wu ,  Shruti Padhee

IPC分类号： A61K38/04 ,  C07K5/12 ,  A61K38/00 ,  A61K38/12 ,  C07K7/64 ,  A61K38/08 ,  G01N33/569 ,  A61K45/06 ,  A61K49/00 ,  C07K7/06

CPC分类号： C07K7/56 ,  A61K38/00 ,  A61K38/08 ,  A61K38/12 ,  A61K45/06 ,  A61K47/543 ,  A61K49/0056 ,  C07K1/10 ,  C07K1/16 ,  C07K7/06 ,  C07K7/64 ,  G01N33/569 ,  Y02A50/40 ,  Y02A50/401 ,  Y02A50/402 ,  Y02A50/411 ,  Y02A50/469 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/478 ,  Y02A50/479 ,  Y02A50/481 ,  Y02A50/483 ,  Y02A50/52 ,  Y02A50/56 ,  Y02A50/59

摘要： The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

摘要翻译： 本发明涉及一种称为γ-AA肽的新型抗微生物剂。 本发明提供各种类型的γ-AA肽，例如线性γ-AA肽，环状γ-AA肽和脂质化的γ-AA肽。 本发明的γ-AA肽被设计成在稳定和无毒的同时发挥抗菌活性。 γ-AA肽也似乎不会导致处理微生物中微生物抗性的发展。 因此，所公开的γ-AA肽可用于治疗与病原微生物相关的各种医学病症。

公开(公告)号：US09234007B2

公开(公告)日：2016-01-12

申请号：US13920693

申请日：2013-06-18

申请人： Jianfeng Cai ,  Youhong Niu ,  Weibo Cai ,  Hao Hong

发明人： Jianfeng Cai ,  Youhong Niu ,  Weibo Cai ,  Hao Hong

IPC分类号： A61K51/00 ,  A61M36/14 ,  C07K7/64 ,  C07K5/08 ,  A61K51/08 ,  C07K5/02 ,  C07K5/09

CPC分类号： C07K7/64 ,  A61K51/08 ,  A61K51/082 ,  A61K51/088 ,  C07K5/0215 ,  C07K5/08 ,  C07K5/0817

摘要： Embodiments of the present disclosure provide for RGD mimetic γ-AApeptide compounds, γ-AApeptide compounds capable of binding an RGD binding site on integrin αvβ3, linear γ-AApeptide compounds, cyclic γ-AApeptide compounds and multimeric RGD mimetic γ-AApeptide compounds, methods of making each, and methods of using each, and the like. In embodiments, the RGD mimetic γ-AApeptide compounds can be used in imaging, diagnostics, and treatment of angiogenesis related conditions.

摘要翻译： 本公开的实施方案提供RGD模拟γ-AA肽化合物，能够结合整联蛋白αv＆bgr; 3，线性γ-AA肽化合物，环状γ-AA肽化合物和多聚RGD模拟γ-AA肽化合物的RGD结合位点的γ-AA肽化合物 ，各种方法，使用方法等。 在实施方案中，RGD模拟γ-AA肽化合物可用于血管生成相关病症的成像，诊断和治疗。

公开(公告)号：US20140004039A1

公开(公告)日：2014-01-02

申请号：US13920693

申请日：2013-06-18

申请人： Jianfeng Cai ,  Youhong Niu ,  Weibo Cai ,  Hao Hong

发明人： Jianfeng Cai ,  Youhong Niu ,  Weibo Cai ,  Hao Hong

IPC分类号： C07K7/64 ,  A61K51/08 ,  C07K5/08

CPC分类号： C07K7/64 ,  A61K51/08 ,  A61K51/082 ,  A61K51/088 ,  C07K5/0215 ,  C07K5/08 ,  C07K5/0817

摘要： Embodiments of the present disclosure provide for RGD mimetic γ-AApeptide compounds, γ-AApeptide compounds capable of binding an RGD binding site on integrin αvβ3, linear γ-AApeptide compounds, cyclic γ-AApeptide compounds and multimeric RGD mimetic γ-AApeptide compounds, methods of making each, and methods of using each, and the like. In embodiments, the RGD mimetic γ-AApeptide compounds can be used in imaging, diagnostics, and treatment of angiogenesis related conditions.

摘要翻译： 本公开的实施方案提供了RGD模拟γ-AA肽化合物，能够结合整合素α2β3，线性γ-AA肽化合物，环状γ-AA肽化合物和多聚RGD模拟γ-AA肽化合物的RGD结合位点的γ-AA肽化合物，方法 各自的使用方法和使用方法等。 在实施方案中，RGD模拟γ-AA肽化合物可用于血管生成相关病症的成像，诊断和治疗。