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公开(公告)号：US20210094998A1
公开(公告)日：2021-04-01
申请号：US17085128
申请日：2020-10-30
发明人： Mark MACIELAG , Raymond J. PATCH , Rui ZHANG , Martin A. CASE , Mark J. WALL , Yue-Mei ZHANG , Shamina M. RANGWALA , James N. LEONARD , Raul C. CAMACHO , Michael J. HUNTER , Katharine E. D'AQUINO , Wilson EDWARDS , Ronald V. SWANSON , Wenying JIAN , Ellen CHI
IPC分类号： C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00
摘要： The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.
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2.发明申请公开(公告)号：US20190298849A1
公开(公告)日：2019-10-03
申请号：US16344174
申请日：2017-10-26
发明人： Mark MACIELAG , Raymond J. PATCH , Rui ZHANG , Martin A. CASE , Shamina M. RANGWALA , James N. LEONARD , Raul C. CAMACHO , Michael J. HUNTER , Katharine E. D'AQUINO , Wilson EDWARDS , Ronald V. SWANSON , Wenying JIAN , Yue-Mei ZHANG , Mark J. WALL , Ellen CHI
摘要： The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.
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3.发明公开公开(公告)号：US20230365644A1
公开(公告)日：2023-11-16
申请号：US18154020
申请日：2023-01-12
发明人： Mark MACIELAG , Raymond J. PATCH , Rui ZHANG , Martin A. CASE , Shamina M. RANGWALA , James N. LEONARD , Raul C. CAMACHO , Michael J. HUNTER , Katharine E. D'AQUINO , Wilson EDWARDS , Ronald V. SWANSON , Wenying JIAN , Yue-Mei ZHANG , Mark WALL , Ellen CHI
IPC分类号： C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00
CPC分类号： C07K14/575 , A61K47/6845 , C07K16/24 , A61K47/68 , A61K47/6883 , A61K9/0019 , A61K38/1709 , A61K38/26 , C07K1/061 , C07K1/1072 , C07K14/57545 , A61K47/64 , A61P3/10 , A61K38/17 , A61K49/0032 , A61K49/0052 , A61K49/0056 , C07K1/12 , C07K1/18 , C07K5/0205 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , A61K47/6811 , C07K16/00 , C07K2317/14 , C07K2317/56 , C07K2317/71 , C07K2317/33 , A61K38/00
摘要： The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.
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公开(公告)号：US20190367577A1
公开(公告)日：2019-12-05
申请号：US16542751
申请日：2019-08-16
发明人： Mark MACIELAG , Raymond J. PATCH , Rui ZHANG , Martin A. CASE , Shamina M. RANGWALA , James N. LEONARD , Raul C. CAMACHO , Michael J. HUNTER , Katharine E. D'AQUINO , Wilson EDWARDS , Ronald V. SWANSON , Wenying JIAN , Yue-Mei ZHANG , Mark J. WALL , Ellen CHI
IPC分类号： C07K14/575 , A61K47/64 , A61P3/10 , A61K38/17 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , A61K47/68 , C07K16/00
摘要： The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.
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公开(公告)号：US20210163566A1
公开(公告)日：2021-06-03
申请号：US17168503
申请日：2021-02-05
发明人： Mark MACIELAG , Raymond J. PATCH , Rui ZHANG , Martin A. CASE , Shamina M. RANGWALA , James N. LEONARD , Raul C. CAMACHO , Michael J. HUNTER , Katharine E. D'AQUINO , Wilson EDWARDS , Ronald V. SWANSON , Wenying JIAN , Yue-Mei ZHANG , Mark J. WALL , Ellen CHI
IPC分类号： C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00
摘要： The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.
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6.发明申请公开(公告)号：US20200283491A1
公开(公告)日：2020-09-10
申请号：US16820174
申请日：2020-03-16
发明人： Mark MACIELAG , Raymond J. PATCH , Rui ZHANG , Martin A. CASE , Shamina M. RANGWALA , James N. LEONARD , Raul C. CAMACHO , Michael J. HUNTER , Katharine E. D'AQUINO , Wilson EDWARDS , Ronald V. SWANSON , Wenying JIAN , Yue-Mei ZHANG , Mark J. WALL , Ellen CHI
IPC分类号： C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00
摘要： The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.
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公开(公告)号：US20190263879A1
公开(公告)日：2019-08-29
申请号：US16344263
申请日：2017-10-26
发明人： Mark MACIELAG , Raymond J. PATCH , Rui ZHANG , Martin A. CASE , Mark J. WALL , Yue-Mei ZHANG , Shamina M. RANGWALA , James N. LEONARD , Raul C. CAMACHO , Michael J. HUNTER , Katharine E. D'AQUINO , Wilson EDWARDS , Ronald V. SWANSON , Wenying JIAN , Ellen CHI
IPC分类号： C07K14/575 , C07K16/00 , C07K16/24 , A61K47/68
摘要： The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.
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