专利检索 ap:("Janssen Pharmaceutica NV") AND inv:"Mark J. WALL" 第 1 页

1.

发明申请
IMMUNOGLOBULINS AND USES THEREOF 有权

公开(公告)号：US20210094998A1

公开(公告)日：2021-04-01

申请号：US17085128

申请日：2020-10-30

申请人： Janssen Pharmaceutica NV

发明人： Mark MACIELAG , Raymond J. PATCH , Rui ZHANG , Martin A. CASE , Mark J. WALL , Yue-Mei ZHANG , Shamina M. RANGWALA , James N. LEONARD , Raul C. CAMACHO , Michael J. HUNTER , Katharine E. D'AQUINO , Wilson EDWARDS , Ronald V. SWANSON , Wenying JIAN , Ellen CHI

IPC分类号： C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00

摘要： The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.

2.

发明申请
Cyclic Peptide Tyrosine Tyrosine Compounds as Modulators of Neuropeptide Y Receptors 有权

公开(公告)号：US20210206822A1

公开(公告)日：2021-07-08

申请号：US17168325

申请日：2021-02-05

申请人： Janssen Pharmaceutica NV

发明人： Mark MACIELAG , Raymond J. PATCH , Rui ZHANG , Martin A. CASE , Mark J. WALL , Yue-Mei ZHANG

IPC分类号： C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00

摘要： The present invention comprises compounds of Formula I. wherein: Z4, Z7, Z9, Z11, Z22, Z23, Z26, Z30, Z34, Z35, p, m, n, q, and BRIDGE are defined in the specification. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel compounds are useful for preventing, treating or ameliorating diseases and disorders, such as obesity, type 2 diabetes, the metabolic syndrome, insulin resistance, and dyslipidemia, among others.

3.

发明申请
GLUCAGON LIKE PEPTIDE 1 (GLP-1) FUSION PEPTIDE COUPLED CYCLIC PEPTIDE TYROSINE TYROSINE CONJUGATES AND USES THEREOF 审中-公开

公开(公告)号：US20190330296A1

公开(公告)日：2019-10-31

申请号：US16392898

申请日：2019-04-24

申请人： Janssen Pharmaceutica NV

发明人： Yue-Mei ZHANG , Raul C. CAMACHO , Martin A. CASE , Ellen CHI , Suzanne EDAVETTAL , Wilson EDWARDS , Lisa NORQUAY , Mark J. WALL , Rui ZHANG , Songmao ZHENG

IPC分类号： C07K14/605 , A61K47/66 , A61P3/06 , A61P3/10 , A61P5/50 , C07K7/64

摘要： The present invention comprises conjugates comprising a glucagon-like peptide 1 (GLP-1) fusion peptide coupled to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.

4.

发明公开
CYCLIC PEPTIDE TYROSINE TYROSINE COMPOUNDS AS MODULATORS OF NEUROPEPTIDE Y RECEPTORS 审中-公开

公开(公告)号：US20240018208A1

公开(公告)日：2024-01-18

申请号：US18343689

申请日：2023-06-28

申请人： Janssen Pharmaceutica NV

发明人： Mark MACIELAG , Raymond J. PATCH , Rui ZHANG , Martin A. CASE , Mark J. WALL , Yue-Mei ZHANG

IPC分类号： C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00

CPC分类号： C07K14/575 , A61K47/6845 , C07K16/24 , A61K47/68 , A61K47/6883 , A61K9/0019 , A61K38/1709 , A61K38/26 , C07K1/061 , C07K1/1072 , C07K14/57545 , A61K47/64 , A61P3/10 , A61K38/17 , A61K49/0032 , A61K49/0052 , A61K49/0056 , C07K1/12 , C07K1/18 , C07K5/0205 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , A61K47/6811 , C07K16/00 , C07K2317/14 , C07K2317/56 , C07K2317/71 , C07K2317/33 , A61K38/00

摘要： The present invention comprises compounds of Formula I.

wherein:
Z4, Z7, Z9, Z11, Z22, Z23, Z26, Z30, Z34, Z35, p, m, n, q, and BRIDGE are defined in the specification. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel compounds are useful for preventing, treating or ameliorating diseases and disorders, such as obesity, type 2 diabetes, the metabolic syndrome, insulin resistance, and dyslipidemia, among others.

5.

发明申请
IMMUNOGLOBULINS AND USES THEREOF 审中-公开

公开(公告)号：US20190367577A1

公开(公告)日：2019-12-05

申请号：US16542751

申请日：2019-08-16

申请人： Janssen Pharmaceutica NV

发明人： Mark MACIELAG , Raymond J. PATCH , Rui ZHANG , Martin A. CASE , Shamina M. RANGWALA , James N. LEONARD , Raul C. CAMACHO , Michael J. HUNTER , Katharine E. D'AQUINO , Wilson EDWARDS , Ronald V. SWANSON , Wenying JIAN , Yue-Mei ZHANG , Mark J. WALL , Ellen CHI

IPC分类号： C07K14/575 , A61K47/64 , A61P3/10 , A61K38/17 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , A61K47/68 , C07K16/00

摘要： The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.

6.

发明申请
GLUCAGON LIKE PEPTIDE 1 (GLP-1) FUSION PEPTIDE COUPLED CYCLIC PEPTIDE TYROSINE TYROSINE CONJUGATES AND USES THEREOF 有权

公开(公告)号：US20210253661A1

公开(公告)日：2021-08-19

申请号：US15733776

申请日：2019-04-24

申请人： Janssen Pharmaceutica NV

发明人： Yue-Mei ZHANG , Raul CAMACHO , Martin A. CASE , Ellen CHI , Suzanne EDAVETTAL , Wilson EDWARDS , Lisa NORQUAY , Mark J. WALL , Rui ZHANG , Songmao ZHENG

IPC分类号： C07K14/605 , C07K14/575 , A61K47/64 , A61P3/04 , A61K9/00

摘要： The present invention comprises conjugates comprising a glucagon-like peptide 1 (GLP-1) fusion peptide coupled to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.

7.

发明申请
ANTIBODY-COUPLED CYCLIC PEPTIDE TYROSINE TYROSINE COMPOUNDS AS MODULATORS OF NEUROPEPTIDE Y RECEPTORS 审中-公开

公开(公告)号：US20190298849A1

公开(公告)日：2019-10-03

申请号：US16344174

申请日：2017-10-26

申请人： Janssen Pharmaceutica NV

发明人： Mark MACIELAG , Raymond J. PATCH , Rui ZHANG , Martin A. CASE , Shamina M. RANGWALA , James N. LEONARD , Raul C. CAMACHO , Michael J. HUNTER , Katharine E. D'AQUINO , Wilson EDWARDS , Ronald V. SWANSON , Wenying JIAN , Yue-Mei ZHANG , Mark J. WALL , Ellen CHI

IPC分类号： A61K47/68 , A61K9/00 , A61K38/26 , A61K38/17 , A61P3/04

摘要： The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.

8.

发明申请
METHOD OF INHIBITING C-KIT KINASE 审中-公开
标题翻译：抑制C-kit激酶的方法

公开(公告)号：US20150094520A1

公开(公告)日：2015-04-02

申请号：US14563126

申请日：2014-12-08

申请人： Janssen Pharmaceutica NV

发明人： Carl R. ILLIG , Shelley K. BALLENTINE , Jinsheng CHEN , Sanath K. MEEGALLA , M. Jonathan RUDOLPH , Mark J. WALL , Kenneth J. WILSON , Renee Louise DESJARLAIS , Carl M. MANTHEY , Christopher J. MOLLOY

IPC分类号： A61K31/5377 , A61K31/496 , A61K45/06 , C07D401/12 , A61K31/454 , A61N5/10 , C07D407/12 , C07D401/14 , A61K31/4545 , A61K31/4178 , C07D409/14 , C07D409/12 , C07D307/68

CPC分类号： A61K31/5377 , A61K31/4178 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K45/06 , A61N5/10 , A61N2005/1098 , C07D307/68 , C07D401/12 , C07D401/14 , C07D407/12 , C07D409/12 , C07D409/14 , C12N9/99

摘要： A method of reducing or inhibiting kinase activity of C-KIT in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to C-KIT using a compound of the present invention: or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof.The present invention is further directed to methods for treating conditions such as cancers and other cell proliferative disorders.

摘要翻译： 降低或抑制细胞或受试者中C-KIT的激酶活性的方法，以及使用这些化合物在受试者中预防或治疗细胞增殖性疾病和/或与C-KIT相关的病症的方法，本发明：或其溶剂合物，水合物，互变异构体或其药学上可接受的盐。本发明还涉及治疗诸如癌症和其它细胞增殖性疾病的病症的方法。