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公开(公告)号：US20210094998A1
公开(公告)日：2021-04-01
申请号：US17085128
申请日：2020-10-30
Applicant: Janssen Pharmaceutica NV
Inventor： Mark MACIELAG , Raymond J. PATCH , Rui ZHANG , Martin A. CASE , Mark J. WALL , Yue-Mei ZHANG , Shamina M. RANGWALA , James N. LEONARD , Raul C. CAMACHO , Michael J. HUNTER , Katharine E. D'AQUINO , Wilson EDWARDS , Ronald V. SWANSON , Wenying JIAN , Ellen CHI
IPC: C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00
Abstract: The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.
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2.发明申请公开(公告)号：US20190298849A1
公开(公告)日：2019-10-03
申请号：US16344174
申请日：2017-10-26
Applicant: Janssen Pharmaceutica NV
Inventor： Mark MACIELAG , Raymond J. PATCH , Rui ZHANG , Martin A. CASE , Shamina M. RANGWALA , James N. LEONARD , Raul C. CAMACHO , Michael J. HUNTER , Katharine E. D'AQUINO , Wilson EDWARDS , Ronald V. SWANSON , Wenying JIAN , Yue-Mei ZHANG , Mark J. WALL , Ellen CHI
Abstract: The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.
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公开(公告)号：US20250026803A1
公开(公告)日：2025-01-23
申请号：US18904962
申请日：2024-10-02
Applicant: Janssen Pharmaceutica NV
Inventor： Mark MACIELAG , Raymond J. PATCH , Rui ZHANG , Martin A. CASE , Mark J. WALL , Yue-Mei ZHANG , Shamina M. RANGWALA , James N. LEONARD , Raul C. CAMACHO , Michael J. HUNTER , Katharine E. D'AQUINO , Wilson EDWARDS , Ronald V. SWANSON , Wenying JIAN , Ellen CHI
IPC: C07K14/575 , A61K9/00 , A61K38/00 , A61K38/17 , A61K38/22 , A61K38/26 , A61K39/00 , A61K45/06 , A61K47/60 , A61K47/64 , A61K47/68 , A61K49/00 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , C07K1/06 , C07K1/107 , C07K1/12 , C07K1/18 , C07K5/02 , C07K16/00 , C07K16/24
Abstract: The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.
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公开(公告)号：US20210206822A1
公开(公告)日：2021-07-08
申请号：US17168325
申请日：2021-02-05
Applicant: Janssen Pharmaceutica NV
Inventor： Mark MACIELAG , Raymond J. PATCH , Rui ZHANG , Martin A. CASE , Mark J. WALL , Yue-Mei ZHANG
IPC: C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00
Abstract: The present invention comprises compounds of Formula I. wherein: Z4, Z7, Z9, Z11, Z22, Z23, Z26, Z30, Z34, Z35, p, m, n, q, and BRIDGE are defined in the specification. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel compounds are useful for preventing, treating or ameliorating diseases and disorders, such as obesity, type 2 diabetes, the metabolic syndrome, insulin resistance, and dyslipidemia, among others.
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公开(公告)号：US20210163566A1
公开(公告)日：2021-06-03
申请号：US17168503
申请日：2021-02-05
Applicant: Janssen Pharmaceutica NV
Inventor： Mark MACIELAG , Raymond J. PATCH , Rui ZHANG , Martin A. CASE , Shamina M. RANGWALA , James N. LEONARD , Raul C. CAMACHO , Michael J. HUNTER , Katharine E. D'AQUINO , Wilson EDWARDS , Ronald V. SWANSON , Wenying JIAN , Yue-Mei ZHANG , Mark J. WALL , Ellen CHI
IPC: C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00
Abstract: The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20200283491A1
公开(公告)日：2020-09-10
申请号：US16820174
申请日：2020-03-16
Applicant: Janssen Pharmaceutica NV
Inventor： Mark MACIELAG , Raymond J. PATCH , Rui ZHANG , Martin A. CASE , Shamina M. RANGWALA , James N. LEONARD , Raul C. CAMACHO , Michael J. HUNTER , Katharine E. D'AQUINO , Wilson EDWARDS , Ronald V. SWANSON , Wenying JIAN , Yue-Mei ZHANG , Mark J. WALL , Ellen CHI
IPC: C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00
Abstract: The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.
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公开(公告)号：US20190263879A1
公开(公告)日：2019-08-29
申请号：US16344263
申请日：2017-10-26
Applicant: Janssen Pharmaceutica NV
Inventor： Mark MACIELAG , Raymond J. PATCH , Rui ZHANG , Martin A. CASE , Mark J. WALL , Yue-Mei ZHANG , Shamina M. RANGWALA , James N. LEONARD , Raul C. CAMACHO , Michael J. HUNTER , Katharine E. D'AQUINO , Wilson EDWARDS , Ronald V. SWANSON , Wenying JIAN , Ellen CHI
IPC: C07K14/575 , C07K16/00 , C07K16/24 , A61K47/68
Abstract: The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.
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公开(公告)号：US20240018208A1
公开(公告)日：2024-01-18
申请号：US18343689
申请日：2023-06-28
Applicant: Janssen Pharmaceutica NV
Inventor： Mark MACIELAG , Raymond J. PATCH , Rui ZHANG , Martin A. CASE , Mark J. WALL , Yue-Mei ZHANG
IPC: C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00
CPC classification number: C07K14/575 , A61K47/6845 , C07K16/24 , A61K47/68 , A61K47/6883 , A61K9/0019 , A61K38/1709 , A61K38/26 , C07K1/061 , C07K1/1072 , C07K14/57545 , A61K47/64 , A61P3/10 , A61K38/17 , A61K49/0032 , A61K49/0052 , A61K49/0056 , C07K1/12 , C07K1/18 , C07K5/0205 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , A61K47/6811 , C07K16/00 , C07K2317/14 , C07K2317/56 , C07K2317/71 , C07K2317/33 , A61K38/00
Abstract: The present invention comprises compounds of Formula I.
wherein:
Z4, Z7, Z9, Z11, Z22, Z23, Z26, Z30, Z34, Z35, p, m, n, q, and BRIDGE are defined in the specification. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel compounds are useful for preventing, treating or ameliorating diseases and disorders, such as obesity, type 2 diabetes, the metabolic syndrome, insulin resistance, and dyslipidemia, among others.-
9.发明公开公开(公告)号：US20230365644A1
公开(公告)日：2023-11-16
申请号：US18154020
申请日：2023-01-12
Applicant: Janssen Pharmaceutica NV
Inventor： Mark MACIELAG , Raymond J. PATCH , Rui ZHANG , Martin A. CASE , Shamina M. RANGWALA , James N. LEONARD , Raul C. CAMACHO , Michael J. HUNTER , Katharine E. D'AQUINO , Wilson EDWARDS , Ronald V. SWANSON , Wenying JIAN , Yue-Mei ZHANG , Mark WALL , Ellen CHI
IPC: C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00
CPC classification number: C07K14/575 , A61K47/6845 , C07K16/24 , A61K47/68 , A61K47/6883 , A61K9/0019 , A61K38/1709 , A61K38/26 , C07K1/061 , C07K1/1072 , C07K14/57545 , A61K47/64 , A61P3/10 , A61K38/17 , A61K49/0032 , A61K49/0052 , A61K49/0056 , C07K1/12 , C07K1/18 , C07K5/0205 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , A61K47/6811 , C07K16/00 , C07K2317/14 , C07K2317/56 , C07K2317/71 , C07K2317/33 , A61K38/00
Abstract: The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.
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公开(公告)号：US20190367577A1
公开(公告)日：2019-12-05
申请号：US16542751
申请日：2019-08-16
Applicant: Janssen Pharmaceutica NV
Inventor： Mark MACIELAG , Raymond J. PATCH , Rui ZHANG , Martin A. CASE , Shamina M. RANGWALA , James N. LEONARD , Raul C. CAMACHO , Michael J. HUNTER , Katharine E. D'AQUINO , Wilson EDWARDS , Ronald V. SWANSON , Wenying JIAN , Yue-Mei ZHANG , Mark J. WALL , Ellen CHI
IPC: C07K14/575 , A61K47/64 , A61P3/10 , A61K38/17 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , A61K47/68 , C07K16/00
Abstract: The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.
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