公开(公告)号：US12098210B2

公开(公告)日：2024-09-24

申请号：US18052174

申请日：2022-11-02

Applicant: JANSSEN BIOTECH, INC.

Inventor： Jenna Goldberg ,  Jagoda Jasielec ,  Raluca Verona ,  Brendan Weiss

IPC: C07K16/28 ,  A61K31/454 ,  A61K31/573 ,  A61K39/00 ,  A61K39/395 ,  A61P35/00 ,  C07K16/30

CPC classification number: C07K16/2878 ,  A61K31/454 ,  A61K31/573 ,  A61K39/3955 ,  A61K39/39558 ,  A61P35/00 ,  C07K16/2809 ,  C07K16/2896 ,  C07K16/30 ,  A61K2039/507 ,  A61K2039/545 ,  C07K2317/31

Abstract: Disclosed are methods of treating cancers and enhancing efficacy of BCMAxCD3 bispecific antibodies. In particular, methods are disclosed of using a BCMAxCD3 bispecific antibody, an anti-CD38 antibody and/or pomalidomide to treat cancers, particularly relapsed or refractory multiple myeloma.

公开(公告)号：US20240076376A1

公开(公告)日：2024-03-07

申请号：US18452751

申请日：2023-08-21

Applicant: JANSSEN BIOTECH, INC.

Inventor： Jenna Goldberg ,  Arnob Banerjee

IPC: C07K16/28 ,  A61K31/138 ,  A61K31/167 ,  A61K31/573 ,  A61K39/395 ,  A61K47/12 ,  A61K47/18 ,  A61K47/26 ,  A61P35/00

CPC classification number: C07K16/2809 ,  A61K31/138 ,  A61K31/167 ,  A61K31/573 ,  A61K39/3955 ,  A61K47/12 ,  A61K47/183 ,  A61K47/26 ,  A61P35/00 ,  C07K16/2878 ,  A61K2039/505 ,  C07K2317/24

Abstract: Described herein are approved products and methods of using approved products for treating relapsed or refractory multiple myeloma in a patient. Also described herein are methods of selling or offering for sale an approved product.

公开(公告)号：US20230295292A1

公开(公告)日：2023-09-21

申请号：US18052172

申请日：2022-11-02

Applicant: Janssen Biotech, Inc.

Inventor： Jenna Goldberg ,  Shun Xin Wang Lin ,  Thomas J. Prior ,  Raluca Verona ,  Brendan Weiss

IPC: C07K16/28 ,  A61P35/00 ,  A61K31/454 ,  A61K31/573 ,  A61K39/395

CPC classification number: C07K16/28 ,  A61K31/454 ,  A61K31/573 ,  A61K39/3955 ,  A61P35/00 ,  C07K16/2809 ,  C07K16/2896 ,  A61K2039/545 ,  C07K2317/31

Abstract: Disclosed are methods of treating cancers and enhancing efficacy of T cell redirecting therapeutics. In particular, methods are disclosed of using a GPRC5DxCD3 bispecific antibody, an anti-CD38 antibody and/or pomalidomide to treat cancers.

公开(公告)号：US20230272102A1

公开(公告)日：2023-08-31

申请号：US18052174

申请日：2022-11-02

Applicant: JANSSEN BIOTECH, INC.

Inventor： Jenna Goldberg ,  Jagoda Jasielec ,  Raluca Verona ,  Brendan Weiss

IPC: C07K16/28 ,  A61K31/454 ,  A61K31/573 ,  A61P35/00 ,  A61K39/395 ,  C07K16/30

CPC classification number: C07K16/2878 ,  C07K16/2809 ,  C07K16/2896 ,  A61K31/454 ,  A61K31/573 ,  A61P35/00 ,  A61K39/3955 ,  A61K39/39558 ,  C07K16/30 ,  A61K2039/545

Abstract: Disclosed are methods of treating cancers and enhancing efficacy of BCMAxCD3 bispecific antibodies. In particular, methods are disclosed of using a BCMAxCD3 bispecific antibody, an anti-CD38 antibody and/or pomalidomide to treat cancers, particularly relapsed or refractory multiple myeloma.

公开(公告)号：US20220373550A1

公开(公告)日：2022-11-24

申请号：US17742076

申请日：2022-05-11

Applicant: Janssen Biotech, Inc.

Inventor： Kodandaram Pillarisetti ,  Suzette Girgis ,  Jenna Goldberg ,  Shun Xin Wang Lin

IPC: G01N33/574

Abstract: Methods of monitoring progression of multiple myeloma or plasmacytoma, particularly relapsed or refractory multiple myeloma, are described. Also described are methods of treating or determining response to a treatment for multiple myeloma or plasmacytoma in a subject.

公开(公告)号：US20240352140A1

公开(公告)日：2024-10-24

申请号：US18439951

申请日：2024-02-13

Applicant: Janssen Biotech, Inc.

Inventor： Homer Adams, III ,  Arnob Banerjee ,  Suzette Girgis ,  Jenna Goldberg ,  Tara Stephenson ,  Raluca Verona ,  Shun xin Wang lin

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  C07K16/46

CPC classification number: C07K16/2878 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61P35/00 ,  C07K16/2809 ,  C07K16/468 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/76

Abstract: Methods of treating cancers using a BCMA×CD3 bispecific antibody arc described.

公开(公告)号：US11952426B2

公开(公告)日：2024-04-09

申请号：US17317789

申请日：2021-05-11

Applicant: Janssen Biotech Inc.

Inventor： Homer Adams ,  Arnob Banerjee ,  Suzette Girgis ,  Jenna Goldberg ,  Tara Stephenson ,  Raluca Verona ,  Shun xin Wang lin

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  C07K16/46 ,  A61K39/00

CPC classification number: C07K16/2878 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61P35/00 ,  C07K16/2809 ,  C07K16/468 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/76

Abstract: Methods of treating cancers using a BCMAxCD3 bispecific antibody are described.

公开(公告)号：US20230061503A1

公开(公告)日：2023-03-02

申请号：US17740665

申请日：2022-05-10

Applicant: Janssen Biotech, Inc. ,  Legend Biotech USA Inc.

Inventor： Muhammad S. AKRAM ,  Kevin C. De Braganca ,  Jenna Goldberg ,  Carolyn Chang Jackson ,  Erin C. Lee ,  Nikoletta Lendvai ,  Maria Marquez de Mondelo ,  Yunsi Olyslager ,  Jun Qiu ,  Enrique Zudaire Ubani ,  Jean Xu

IPC: A61K35/17 ,  A61P35/00 ,  A61K31/573 ,  A61K45/06 ,  G01N33/68

Abstract: The present disclosure relates to methods of early identification and detection of neurotoxicity associated with the administration of chimeric antigen receptor (CAR) T cell therapy and mitigation strategies to reduce the occurrence and/or severity of treatment associated neurotoxicity.