公开(公告)号：US20220064254A1

公开(公告)日：2022-03-03

申请号：US16936719

申请日：2020-07-23

Applicant: Janssen Biotech, Inc.

Inventor： Raymond BRITTINGHAM ,  Rajkumar GANESAN ,  Sherry LA PORTE ,  John T. LEE ,  Jinquan LUO ,  Theresa MCDEVITT ,  Fei SHEN ,  Sanjaya SINGH ,  Degang SONG ,  Sathyadevi VENKATARAMANI ,  Fang YI ,  Yonghong ZHAO

IPC: C07K14/725 ,  A61K35/17 ,  C07K16/40 ,  C07K14/705

Abstract: The present disclosure provides for chimeric antigen receptors (CARs) that specifically target a human Kallikrein-2 (hK2), and immunoresponsive cells comprising such CARs, for the treatment of cancer.

公开(公告)号：US20230174651A1

公开(公告)日：2023-06-08

申请号：US17844484

申请日：2022-06-20

Applicant: Janssen Biotech, Inc.

Inventor： Jun CHEN ,  Martin Jack BORROK, III ,  Rajkumar GANESAN ,  Degang SONG ,  Shixue SHEN ,  Bonnie WU

IPC: C07K16/28 ,  G01N33/50 ,  G01N33/68

CPC classification number: C07K16/2815 ,  G01N33/5005 ,  G01N33/68 ,  C07K2317/622 ,  C07K2317/565 ,  C07K2317/24 ,  C07K2317/21 ,  G01N2333/70517

Abstract: An antibody that binds a CD8α hinge region, wherein the antibody is capable of binding to a functional exogenous receptor, and wherein the functional exogenous receptor comprises an extracellular domain, the CD8α hinge region, a transmembrane domain, and an intracellular signaling domain.