公开(公告)号：US20230174651A1

公开(公告)日：2023-06-08

申请号：US17844484

申请日：2022-06-20

Applicant: Janssen Biotech, Inc.

Inventor： Jun CHEN ,  Martin Jack BORROK, III ,  Rajkumar GANESAN ,  Degang SONG ,  Shixue SHEN ,  Bonnie WU

IPC: C07K16/28 ,  G01N33/50 ,  G01N33/68

CPC classification number: C07K16/2815 ,  G01N33/5005 ,  G01N33/68 ,  C07K2317/622 ,  C07K2317/565 ,  C07K2317/24 ,  C07K2317/21 ,  G01N2333/70517

Abstract: An antibody that binds a CD8α hinge region, wherein the antibody is capable of binding to a functional exogenous receptor, and wherein the functional exogenous receptor comprises an extracellular domain, the CD8α hinge region, a transmembrane domain, and an intracellular signaling domain.