公开(公告)号：US20060240492A1

公开(公告)日：2006-10-26

申请号：US11272467

申请日：2005-11-11

Applicant: James Rusling ,  Fotios Papadimitrakopoulos

Inventor： James Rusling ,  Fotios Papadimitrakopoulos

IPC: G01N33/574

CPC classification number: G01N33/551

Abstract: An immunoassay device comprises a plurality of carbon nanotubes having a first end and a second end, wherein the nanotubes are aligned substantially parallel relative to one another; a substrate responsive to an electrochemical signal, the substrate being attached to the first end of at least a portion of the plurality of nanotubes; and a capture antibody attached to at least a portion of the nanotubes not at the first end. An immunoassay method comprises providing the disclosed immunoassay device, contacting the immunoassay with a test sample under conditions suitable for binding of an analyte to the capture antibody, wherein binding of the analyte generates, directly or indirectly, an electrochemical signal and detecting the signal. Methods of making the disclosed immunoassay device are also disclosed.

Abstract translation: 免疫测定装置包括具有第一端和第二端的多个碳纳米管，其中所述纳米管相对于彼此基本平行排列; 响应于电化学信号的衬底，所述衬底附接到所述多个纳米管的至少一部分的第一端; 以及不在第一端附着于纳米管的至少一部分的捕获抗体。 免疫测定方法包括提供所公开的免疫测定装置，在适于将分析物与捕获抗体结合的条件下，将免疫测定与测试样品接触，其中分析物的结合直接或间接产生电化学信号并检测信号。 还公开了制备所公开的免疫测定装置的方法。

公开(公告)号：US09402574B2

公开(公告)日：2016-08-02

申请号：US13164656

申请日：2011-06-20

Applicant: Liangliang Qiang ,  Santhisagar Vaddiraju ,  Fotios Papadimitrakopoulos

Inventor： Liangliang Qiang ,  Santhisagar Vaddiraju ,  Fotios Papadimitrakopoulos

IPC: A61B5/00 ,  A61B5/1486 ,  A61B5/1473

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/1495 ,  A61B2560/0223 ,  A61B2562/028 ,  A61B2562/0285 ,  A61B2562/04 ,  A61B2562/125

Abstract: Disclosed herein is a sensor comprising a conduit; the conduit comprising an organic polymer; a working electrode; the working electrode being etched and decorated with a nanostructured material; a reference electrode; and a counter electrode; the working electrode, the reference electrode and the counter electrode being disposed in the conduit; the working electrode, the reference electrode and the counter electrode being separated from each other by an electrically insulating material; and wherein a cross-sectional area of the conduit that comprises a section of the working electrode, a section of the reference electrode and a section of the counter electrode is exposed to detect analytes.

Abstract translation: 本文公开了一种传感器，其包括导管; 导管包含有机聚合物; 工作电极 工作电极用纳米结构材料进行蚀刻和装饰; 参考电极; 和对电极; 工作电极，参比电极和对电极设置在导管中; 工作电极，参考电极和对电极通过电绝缘材料彼此分离; 并且其中包括所述工作电极的一部分，参考电极的一部分和所述对电极的一部分的所述导管的横截面面积被暴露以检测分析物。

公开(公告)号：US08193430B2

公开(公告)日：2012-06-05

申请号：US12348631

申请日：2009-01-05

Applicant: Fotios Papadimitrakopoulos ,  Sang-Yong Ju

Inventor： Fotios Papadimitrakopoulos ,  Sang-Yong Ju

IPC: B01D21/26 ,  C02F1/38

CPC classification number: B01D15/08 ,  B01D15/34 ,  B01D15/363 ,  B03D3/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/174 ,  C01B2202/02 ,  C01B2202/20 ,  C07H19/207 ,  Y10S977/742 ,  Y10S977/751 ,  Y10S977/842 ,  Y10S977/845

Abstract: Disclosed herein too is a method that includes dispersing nanotubes in media that comprises flavin moieties substituted with solubilizing side chains, and/or non-flavin containing molecular species; self-assembling the flavin moieties and other non-flavin containing molecular species in a pattern that is orderly wrapped around the nanotubes to form a composite; introducing desired amounts of an optional reagent that competes with self-assembly in order to disturb the wrapping around nanotubes with moderate order; and centrifuging the mass of the nanotubes and the composites to extract the composite from other nanotubes that are not in composite form.

Abstract translation: 本文还公开了一种方法，其包括将纳米管分散在包含被增溶侧链取代的黄素部分和/或含有非黄素的分子种类的介质中; 以有序地缠绕在纳米管周围形成复合材料的图案自组装黄素部分和其它含有非黄素的分子物质; 引入所需量的与自组装竞争的任选试剂，以便以适度的顺序扰乱纳米管周围的缠绕; 并离心纳米管和复合物的质量以从不是复合形式的其他纳米管中提取复合材料。

公开(公告)号：US07115168B2

公开(公告)日：2006-10-03

申请号：US11045034

申请日：2005-05-03

Applicant: Daniel Harrison Grantham ,  Thomas Samuel Phely-Bobin ,  Fotios Papadimitrakopoulos ,  Faquir C. Jain

Inventor： Daniel Harrison Grantham ,  Thomas Samuel Phely-Bobin ,  Fotios Papadimitrakopoulos ,  Faquir C. Jain

IPC: C23C14/04

CPC classification number: C23C14/044 ,  C23C14/22 ,  H01L51/001

Abstract: Scanning localized evaporation and deposition of an evaporant on a substrate utilizes a mask assembly comprised of a series of mask elements with openings thereon and spaced apart in a stack. The openings are aligned so as to direct the evaporant therethrough onto the substrate. The mask elements are heated and the stack may include a movable shutter element to block openings in adjacent mask elements. The evaporant streams are usually vertical but some may be oblique to the substrate, and they may be of different materials.

Abstract translation: 将蒸发器的局部蒸发和沉积扫描在基底上使用掩模组件，该掩模组件由其上具有开口的一系列掩模元件组成并且在堆叠中间隔开。 开口对准，以将蒸发器引导到基板上。 掩模元件被加热并且堆叠可以包括可移动的快门元件以阻挡相邻的掩模元件中的开口。 蒸发剂流通常是垂直的，但是一些可以与衬底倾斜，并且它们可以是不同的材料。

公开(公告)号：US20060118047A1

公开(公告)日：2006-06-08

申请号：US11327756

申请日：2006-01-09

Applicant: Fotios Papadimitrakopoulos ,  Thomas Phely-Bobin ,  Deniel Grantham ,  Faquir Jain

Inventor： Fotios Papadimitrakopoulos ,  Thomas Phely-Bobin ,  Deniel Grantham ,  Faquir Jain

IPC: C23C16/00

CPC classification number: C23C14/042 ,  C23C14/246 ,  C23C14/26 ,  C23C14/568 ,  H01L51/56

Abstract: The invention decribes an apparatus, Scanning Localized Evaporation Methodology (SLEM) for the close proximity deposition of thin films with high feature definition, high deposition rates, and significantly improved material economy. An array of fixed thin film heating elements, each capable of being individually energized, is mounted on a transport mechanism inside a vacuum chamber. The evaporable material is deposited on a heating element. The SLEM system loads the surface of heating elements, made of foils, with evaporable material. The loaded thin film heating element is transported to the substrate site for re-evaporation. The re-evaporation onto a substrate, which is maintained at the desired temperature, takes place through a mask. The mask, having patterned openings dictated by the structural requirements of the fabrication, may be heated to prevent clogging of the openings. The translation of the substrate past the evaporation site permits replication of the pattern over its entire surface. A multiplicity of fixed thin film heating element arrays is provided that can operate simultaneously or in sequence. Multi-layered structures of evaporable materials with high in-plane spatial pattern resolution can be deposited using this apparatus. In one version of the invention, the transport of the evaporant-loaded thin film heating elements is accomplished by the use of cylindrical rotors on whose circumference the heating elements are mounted.

Abstract translation: 本发明描述了用于紧密沉积具有高特征定义，高沉积速率和显着改善的材料经济性的薄膜的扫描定位蒸发方法（SLEM）的装置。 一组固定的薄膜加热元件，每个固定的薄膜加热元件均能分别通电，安装在真空室内的输送机构上。 蒸发材料沉积在加热元件上。 SLEM系统用可蒸发材料加载由箔制成的加热元件的表面。 负载的薄膜加热元件被输送到基底部位以进行再蒸发。 通过掩模将保持在所需温度下的基底上的再蒸发发生。 可以加热具有由制造的结构要求所规定的图案化开口的掩模，以防止开口堵塞。 衬底经过蒸发位置的平移允许在其整个表面上复制图案。 提供了可以同时或依次操作的多个固定薄膜加热元件阵列。 可以使用该装置沉积具有高面内空间图案分辨率的蒸发材料的多层结构。 在本发明的一个实施例中，通过使用圆周转子来实现蒸发负载的薄膜加热元件的输送，圆柱形转子的圆周上装有加热元件。

公开(公告)号：US20050006656A1

公开(公告)日：2005-01-13

申请号：US10805070

申请日：2004-03-22

Applicant: Faquir Jain ,  Fotios Papadimitrakopoulos

Inventor： Faquir Jain ,  Fotios Papadimitrakopoulos

IPC: C09K11/02 ,  C09K11/08 ,  C09K11/64 ,  C09K11/88 ,  H01L33/18 ,  H05B33/14 ,  H05B33/00

CPC classification number: B82Y30/00 ,  B82Y20/00 ,  C09K11/025 ,  C09K11/0883 ,  C09K11/64 ,  C09K11/883 ,  H01L33/18 ,  H05B33/14 ,  Y10S428/917 ,  Y10S977/952

Abstract: This invention discloses novel device structures for full color flat panel displays utilizing pseudomorphically cladded quantum dot nanocrystals. Different colors are obtained by changing the core size and composition of the quantum dots while maintaining a nearly defect-free lattice at the core-cladding interface. Light emission from the quantum dot core is obtained either by injection or by avalanche electroluminescence. A nanotip emitter device is also presented. These generic devices can be addressed using a variety of conventional display drivers, including active and passive matrix configurations.

Abstract translation: 本发明公开了利用假构造的量子点纳米晶体的全彩平板显示器的新型器件结构。 通过改变核心尺寸和量子点的组成，同时在芯 - 包层界面处保持几乎无缺陷的晶格，可获得不同的颜色。 通过注射或雪崩电致发光获得量子点核的发光。 还提出了一种纳米尖端发射器件。 这些通用设备可以使用各种常规显示驱动器来解决，包括主动和被动矩阵配置。

公开(公告)号：US5946550A

公开(公告)日：1999-08-31

申请号：US818382

申请日：1997-03-14

Applicant: Fotios Papadimitrakopoulos

Inventor： Fotios Papadimitrakopoulos

IPC: H01L51/00 ,  H01L51/30 ,  H01L51/50 ,  H01L35/24 ,  B23B27/00 ,  H01L33/00

CPC classification number: H01L51/5012 ,  B82Y10/00 ,  B82Y30/00 ,  H01L51/0077 ,  H01L51/0079 ,  H01L51/0034 ,  H01L51/0595 ,  Y10S257/918 ,  Y10T428/31551 ,  Y10T428/31573

Abstract: A method for producing a ultrathin semiconducting film, utilizes a substrate with a reactive functionalized surface which is contacted with a reactant compound of a divalent and trivalent chelating metal to produce a metallo-functionalized surface. The metallo-functionalized surface is contacted with bisquinoline or a bisquinoline to produce a deposit of an oligomeric metallo-bisquinoline chelate, which is then contacted with the reactant metal compound to produce a fresh metallo-functionalized surface on the deposit. The fresh metallo-functionalized surface is contacted with the bisquinoline reactant to produce a further deposit of the oligomeric metallo-bisquinoline chelate, and these steps are repeated until a desired thickness of the deposit has been attained.

Abstract translation: 一种制造超薄半导体膜的方法，利用具有与二价和三价螯合金属的反应物化合物接触的反应性官能化表面的基底以产生金属官能化表面。 金属官能化的表面与双喹啉或双喹啉接触以产生低聚金属 - 双喹啉螯合物的沉积物，然后与反应物金属化合物接触以在沉积物上产生新的金属官能化表面。 新鲜的金属官能化表面与双喹啉反应物接触以产生低聚金属 - 双喹啉螯合物的进一步沉积，并重复这些步骤，直至达到所需的沉积厚度。

公开(公告)号：US09509400B2

公开(公告)日：2016-11-29

申请号：US15149908

申请日：2016-05-09

Applicant: Faquir C Jain ,  Fotios Papadimitrakopoulos ,  Robert A Croce, Jr. ,  Pawan Gogna ,  Syed Kamrul Islam ,  Liang Zuo ,  Kai Zhu

Inventor： Faquir C Jain ,  Fotios Papadimitrakopoulos ,  Robert A Croce, Jr. ,  Pawan Gogna ,  Syed Kamrul Islam ,  Liang Zuo ,  Kai Zhu

IPC: H04J14/02 ,  H04B10/11 ,  G01N27/414 ,  A61B5/00 ,  A61B5/145

CPC classification number: H04B10/11 ,  A61B5/0031 ,  A61B5/14503 ,  G01N27/4145 ,  H04B10/1149 ,  H04J14/02

Abstract: An implantable bio-sensing platform architecture that enables the wireless selection, calibration and reading of multiple sensors, as well as checking the power levels of the solar powering source energizing various electronic and optoelectronic devices and circuits embedded in the platform. It also permits checking the operation of the potentiostats interfacing with each amperometric analyte sensor. The platform is flexible to include FET based sensors for protein sensing as well as other applications including pH sensing. In addition, other physiological sensors can be integrated in the platform.

公开(公告)号：US09101301B2

公开(公告)日：2015-08-11

申请号：US13586436

申请日：2012-08-15

Applicant: Fotios Papadimitrakopoulos ,  Santhisagar Vaddiraju

Inventor： Fotios Papadimitrakopoulos ,  Santhisagar Vaddiraju

IPC: A61B5/145 ,  A61B5/1459 ,  A61B5/1486 ,  A61B5/1495 ,  C12Q1/00 ,  G01N33/52

CPC classification number: A61B5/145 ,  A61B5/14503 ,  A61B5/1459 ,  A61B5/14865 ,  A61B5/1495 ,  A61B2562/18 ,  A61B2562/247 ,  C12Q1/001 ,  G01N33/52

Abstract: Disclosed herein is a device comprising a biosensor having disposed upon it a coating; the coating comprising a polymer matrix; where the polymer matrix is operative to facilitate the inwards and outwards diffusion of analytes and byproducts to and from the sensing element of the biosensor; and a sacrificial moiety; the sacrificial moiety being dispersed in the polymer matrix, where the sacrificial moiety erodes with time and increases the porosity of the polymer matrix thus offsetting decreases in analyte permeability as a result of biofouling.

Abstract translation: 本文公开了一种包括生物传感器的装置，其上设置有涂层; 所述涂层包含聚合物基质; 其中聚合物基质可操作以促进分析物和副产物向和从生物传感器的感测元件向外和向外扩散; 和牺牲部分; 牺牲部分分散在聚合物基体中，其中牺牲部分随时间而侵蚀，并增加聚合物基体的孔隙率，从而抵消作为生物污损的结果的分析物渗透性的降低。

公开(公告)号：US08608922B2

公开(公告)日：2013-12-17

申请号：US12614893

申请日：2009-11-09

Applicant: Fotios Papadimitrakopoulos ,  Santhisagar Vaddiraju ,  Faquir Chand Jain ,  Ioannis C. Tomazos

Inventor： Fotios Papadimitrakopoulos ,  Santhisagar Vaddiraju ,  Faquir Chand Jain ,  Ioannis C. Tomazos

IPC: G01N27/327

CPC classification number: C12Q1/002 ,  G01N33/6803

Abstract: A biosensor comprises a substrate; a reference electrode; a working electrode; a counter electrode; and a plurality of permeability adjusting spacers. The reference electrode, the working electrode and the plurality of permeability adjusting spacers are all being disposed to be substantially parallel to each other to create a plurality of enzyme containing porous sections. The enzyme containing porous sections contain an enzyme; where the enzyme is operative to react with a metabolite to determine the concentration of the metabolite. By combining a number of the aforementioned biosensors, the differential concentration of a target enzyme or protein is determined by monitoring the changes on its metabolite substrates.

Abstract translation: 生物传感器包括基底; 参考电极; 工作电极 对电极 和多个导磁率调节间隔件。 参考电极，工作电极和多个磁导率调节间隔物都被设置成基本上彼此平行，以产生多个含酶多孔部分。 含有多孔切片的酶含有酶; 其中酶可用于与代谢物反应以确定代谢物的浓度。 通过组合上述生物传感器，通过监测其代谢物底物的变化来确定靶酶或蛋白质的不同浓度。