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    2-O sulfatase compositions and related methods
    2.
    发明授权
    2-O sulfatase compositions and related methods 有权
    2-O硫酸酯酶组合物及相关方法

    公开(公告)号：US07270815B2

    公开(公告)日：2007-09-18

    申请号：US10753761

    申请日：2004-01-07

    申请人： Ram Sasisekharan ,  James R. Myette ,  Zachary Shriver ,  Ganesh Venkataraman

    发明人： Ram Sasisekharan ,  James R. Myette ,  Zachary Shriver ,  Ganesh Venkataraman

    IPC分类号： A61K38/46 ,  C12N9/14

    CPC分类号： C12N9/16 ,  A61K38/00 ,  C12P19/04 ,  G01N33/5041 ,  G01N2400/40

    摘要： The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.

    摘要翻译： 本发明涉及2-O硫酸酯酶及其用途。 特别地，本发明涉及编码这些分子的重组产生的2-O硫酸酯酶，功能变体和核酸分子。 本发明还提供了用于各种目的的2-O硫酸酯酶的方法，包括降解和分析样品中存在的糖胺聚糖（GAG）。 例如，2-O硫酸酯酶可用于测定样品中存在的糖胺聚糖的纯度，同一性，组成和顺序。 本发明还涉及抑制血管生成和细胞增殖的方法以及使用2-O硫酸酯酶降解产生的2- O硫酸酯酶和/或GAG片段来治疗癌症，神经变性疾病，动脉粥样硬化和微生物感染的方法。

    2-O sulfatase compositions and methods of analyzing therewith
    9.
    发明授权
    2-O sulfatase compositions and methods of analyzing therewith 有权
    2-O硫酸酯酶组合物及其分析方法

    公开(公告)号：US07429474B2

    公开(公告)日：2008-09-30

    申请号：US11433228

    申请日：2006-05-11

    申请人： Ram Sasisekharan ,  James R. Myette ,  Zachary Shriver ,  Ganesh Venkataraman

    发明人： Ram Sasisekharan ,  James R. Myette ,  Zachary Shriver ,  Ganesh Venkataraman

    IPC分类号： C12N9/16

    CPC分类号： C12N9/16 ,  A61K38/00 ,  C12P19/04 ,  G01N33/5041 ,  G01N2400/40

    摘要： The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.

    摘要翻译： 本发明涉及2-O硫酸酯酶及其用途。 特别地，本发明涉及编码这些分子的重组产生的2-O硫酸酯酶，功能变体和核酸分子。 本发明还提供了用于各种目的的2-O硫酸酯酶的方法，包括降解和分析样品中存在的糖胺聚糖（GAG）。 例如，2-O硫酸酯酶可用于测定样品中存在的糖胺聚糖的纯度，同一性，组成和顺序。 本发明还涉及抑制血管生成和细胞增殖的方法以及使用2-O硫酸酯酶降解产生的2- O硫酸酯酶和/或GAG片段来治疗癌症，神经变性疾病，动脉粥样硬化和微生物感染的方法。

    2-O sulfatase compositions and methods of hydrolyzing therewith
    10.
    发明授权
    2-O sulfatase compositions and methods of hydrolyzing therewith 有权
    2-O硫酸酯酶组合物及其水解方法

    公开(公告)号：US07247445B2

    公开(公告)日：2007-07-24

    申请号：US11432824

    申请日：2006-05-11

    申请人： Ram Sasisekharan ,  James R. Myette ,  Zachary Shriver ,  Ganesh Venkataraman

    发明人： Ram Sasisekharan ,  James R. Myette ,  Zachary Shriver ,  Ganesh Venkataraman

    IPC分类号： C12Q1/44 ,  C12N9/16

    CPC分类号： C12N9/16 ,  A61K38/00 ,  C12P19/04 ,  G01N33/5041 ,  G01N2400/40

    摘要： The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.

    摘要翻译： 本发明涉及2-O硫酸酯酶及其用途。 特别地，本发明涉及编码这些分子的重组产生的2-O硫酸酯酶，功能变体和核酸分子。 本发明还提供了用于各种目的的2-O硫酸酯酶的方法，包括降解和分析样品中存在的糖胺聚糖（GAG）。 例如，2-O硫酸酯酶可用于测定样品中存在的糖胺聚糖的纯度，同一性，组成和顺序。 本发明还涉及抑制血管生成和细胞增殖的方法以及使用2-O硫酸酯酶降解产生的2- O硫酸酯酶和/或GAG片段来治疗癌症，神经变性疾病，动脉粥样硬化和微生物感染的方法。