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公开(公告)号：US20230250171A1
公开(公告)日：2023-08-10
申请号：US18307146
申请日：2023-04-26
发明人： Patrick John Doonan , Rajkumar Ganesan , Mehabaw Getahun Derebe , Sathyadevi Venkataramani , Sanjaya Singh , Iqbal S. Grewal , Karla R. Wiehagen
CPC分类号： C07K16/2803 , C07K16/2809 , C07K16/2815 , C07K16/2827 , C07K16/2866 , C07K16/2818 , A61P35/00 , A61K39/4631 , A61K39/464411 , C07K2317/622 , C07K2319/31 , C07K2317/31 , C07K2317/22 , C07K2317/21
摘要： The invention provides antigen binding domains that bind myeloid cell surface antigen CD33 protein comprising the antigen binding domains that bind CD33, polynucleotides encoding them, vectors, host cells, methods of making and using them.
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公开(公告)号：US20220306739A1
公开(公告)日：2022-09-29
申请号：US17186704
申请日：2021-02-26
发明人： Rajkumar Ganesan , Iqbal S. Grewal , Sanjaya Singh
摘要： Anti-TRGV9 molecules, such as anti-TRGV9 antibodies or antigen binding fragments thereof, are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases.
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公开(公告)号：US11639396B2
公开(公告)日：2023-05-02
申请号：US17672471
申请日：2022-02-15
发明人： Sanjaya Singh , Rajkumar Ganesan , Jun Chen , Iqbal S. Grewal
摘要： Molecules, including antibodies and antigen-binding fragments thereof that specifically bind to a linker peptide, and methods of producing and using the described antibodies and antigen-binding fragments are presented herein. Also presented herein methods of generating antibodies that specifically bind to an immunorecessive epitope.
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公开(公告)号：US20210214440A1
公开(公告)日：2021-07-15
申请号：US17125162
申请日：2020-12-17
摘要： An isolated molecule, comprising: a first antigen binding domain and a second antigen binding domain, wherein the first antigen binding domain specifically binds CD8 and the second antigen binding domain specifically binds a T cell receptor (TCR) complex.
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公开(公告)号：US20210284730A1
公开(公告)日：2021-09-16
申请号：US17200287
申请日：2021-03-12
发明人： Rajkumar Ganesan , Iqbal S. Grewal , Sanjaya Singh
摘要： Anti-TRDV2 multispecific antibodies or antigen binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases.
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公开(公告)号：US20210032338A1
公开(公告)日：2021-02-04
申请号：US16869401
申请日：2020-05-07
发明人： Rajkumar Ganesan , Iqbal S. Grewal , Sanjaya Singh
摘要： Anti-TRGV9 antibodies or antigen binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases, such as cancer.
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公开(公告)号：US20240247063A1
公开(公告)日：2024-07-25
申请号：US18609023
申请日：2024-03-19
IPC分类号： C07K16/28 , A61P35/00 , C07K16/30 , C12N5/0783 , A61K39/00
CPC分类号： C07K16/2809 , A61P35/00 , C07K16/28 , C07K16/2866 , C07K16/2878 , C07K16/3069 , C12N5/0636 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/565 , C07K2317/92
摘要： Anti-Vβ17 antibodies or antigen binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases.
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公开(公告)号：US11926667B2
公开(公告)日：2024-03-12
申请号：US17499597
申请日：2021-10-12
CPC分类号： C07K16/2812 , C07K16/2815 , C07K16/468 , C07K2317/34 , C07K2317/565
摘要： Provided herein, in certain aspects, are antibodies that bind to CD8, as well as recombinant cells containing the vectors, and compositions comprising the antibodies. Also provided herein, in certain aspects, are antibodies that bind to CD4, as well as recombinant cells containing the vectors, and compositions comprising the antibodies. Also provided herein, in certain aspects, are multispecific antibodies that bind to CD4 and CD8, as well as recombinant cells containing the vectors, and compositions comprising the antibodies. Methods of making the antibodies are also provided.
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公开(公告)号：US20230365683A1
公开(公告)日：2023-11-16
申请号：US18307076
申请日：2023-04-26
发明人： Patrick John Doonan , Rajkumar Ganesan , Mehabaw Getahun Derebe , Sathyadevi Venkataramani , Sanjaya Singh , Iqbal S. Grewal , Karla R. Wiehagen
CPC分类号： C07K16/2803 , A61K39/4631 , A61K39/464411 , A61K39/4611 , C07K16/2809 , A61K51/1096 , A61K51/1027 , A61P35/00 , C07K2317/622 , C07K2317/22 , C07K2317/92 , C07K2317/24 , C07K2317/31 , C07K2317/77 , C07K2317/73
摘要： The invention provides antigen binding domains that bind myeloid cell surface antigen CD33 protein comprising the antigen binding domains that bind CD33, polynucleotides encoding them, vectors, host cells, methods of making and using them.
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公开(公告)号：US11667712B2
公开(公告)日：2023-06-06
申请号：US16869401
申请日：2020-05-07
发明人： Rajkumar Ganesan , Iqbal S. Grewal , Sanjaya Singh
CPC分类号： C07K16/2809 , A61K38/1709 , C07K16/2866 , C07K2317/24 , C07K2317/31 , C07K2317/565
摘要： Anti-TRGV9 antibodies or antigen binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases, such as cancer.
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