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1.发明申请DELTA 4, 5 GLYCURONIDASE COMPOSITIONS AND METHODS RELATED THERETO 审中-公开DELTA 4，5 GLYCURONIDASE组合物及其相关方法公开(公告)号：US20120045425A1
公开(公告)日：2012-02-23
申请号：US13082745
申请日：2011-04-08
申请人： JAMES R. MYETTE , ZACHARY SHRIVER , GANESH VENKATARAMAN , RAM SASISEKHARAN , MAITLAND W. MCLEAN
发明人： JAMES R. MYETTE , ZACHARY SHRIVER , GANESH VENKATARAMAN , RAM SASISEKHARAN , MAITLAND W. MCLEAN
IPC分类号： A61K38/47 , C02F3/34 , A61P7/00 , A61K31/711 , A61P35/00
CPC分类号： C12Y302/01056 , A61K38/00 , C07H21/04 , C12N9/2402 , C12Q1/34 , C12Y302/01166 , Y02A50/481
摘要： The invention relates to Δ4,5 glycuronidase, related compositions, and methods of use thereof.
摘要翻译： 本发明涉及＆amp; 4,5g糖醛酸糖苷酶，相关组合物及其使用方法。
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公开(公告)号：US20110288046A1
公开(公告)日：2011-11-24
申请号：US13086054
申请日：2011-04-13
IPC分类号： A61K31/727 , A61P7/02 , G01N30/02 , C08B37/10
CPC分类号： G01N33/66 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333 , Y10T436/17 , Y10T436/24
摘要： The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described.
摘要翻译： 本发明涉及与分析和监测硫酸多糖的异质种群相关的方法和产品。 特别是包括低分子量肝素产品的治疗性肝素产品以及分析和监测这些产品的方法进行了描述。
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公开(公告)号：US20120027744A1
公开(公告)日：2012-02-02
申请号：US13076066
申请日：2011-03-30
申请人： DONGFANG LIU , KEVIN POJASEK , ZACHARY SHRIVER , KRISTINE HOLLEY , YOSUF EL-SHABRAWI , GANESH VENKATARAMAN , RAM SASISEKHARAN
发明人： DONGFANG LIU , KEVIN POJASEK , ZACHARY SHRIVER , KRISTINE HOLLEY , YOSUF EL-SHABRAWI , GANESH VENKATARAMAN , RAM SASISEKHARAN
IPC分类号： A61K38/51 , A61P35/00 , A61P35/04 , C12N5/09 , A61K31/7016
CPC分类号： C12P19/26 , A61K31/726 , A61K38/51 , C08B37/0075 , C12N9/88 , C12Q1/527 , G01N2333/988 , G01N2500/02 , Y10S530/811 , A61K31/00 , A61K2300/00
摘要： The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
摘要翻译： 本发明涉及肝素酶III及其突变体。 根据本发明已经发现具有降低的酶活性的修饰形式的肝素酶III可用于各种目的，包括肝素样糖胺聚糖（HLGAG）的测序，从溶液中除去活性硫酸乙酰肝素，血管生成抑制等 。 本发明在其它方面涉及使用肝素酶III或通过HLGAG的肝素酶III的酶切割产生的产物来治疗癌症并抑制肿瘤细胞生长和/或转移的方法。
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4.发明申请公开(公告)号：US20090119027A1
公开(公告)日：2009-05-07
申请号：US12260992
申请日：2008-10-29
IPC分类号： G06F19/00
CPC分类号： C07K1/00 , G16B50/00 , G16C20/20 , Y10S707/99936 , Y10S707/99943
摘要： The invention relates to methods of identifying and characterizing properties of polymers to provide information about the polymer such as the charge of the polymer, the number and types or characteristics of units of the polymer and the sequence of the polymers. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction.
摘要翻译： 本发明涉及确定和表征聚合物性质以提供关于聚合物的信息的方法，例如聚合物的电荷，聚合物单元的数量，类型或特性以及聚合物的顺序。 本发明还涉及聚合物如核酸，多肽和多糖的测序方法以及鉴定多糖 - 蛋白质相互作用的方法。
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公开(公告)号：US20090061411A1
公开(公告)日：2009-03-05
申请号：US12203629
申请日：2008-09-03
IPC分类号： C12Q1/00
CPC分类号： G01N33/66 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333 , Y10T436/17 , Y10T436/24
摘要： The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described.
摘要翻译： 本发明涉及与分析和监测硫酸多糖的异质种群相关的方法和产品。 特别是包括低分子量肝素产品的治疗性肝素产品以及分析和监测这些产品的方法进行了描述。
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