公开(公告)号：US5976836A

公开(公告)日：1999-11-02

申请号：US852401

申请日：1997-05-07

申请人： J. Mark Weber ,  Paul E. Hessler ,  Peter E. Larsen ,  Minh B. Luu

发明人： J. Mark Weber ,  Paul E. Hessler ,  Peter E. Larsen ,  Minh B. Luu

IPC分类号： C07K14/395 ,  C12P19/62 ,  C12P21/06 ,  C07H21/04 ,  C12N1/20 ,  C12N9/24

CPC分类号： C12P19/62 ,  C07K14/395

摘要： The present invention provides isolated and purified polypeptides that increase antibiotic production, polynucleotides that encode those polypeptides, expression vectors containing those polynucleotides, host cells transformed with those expression vectors, a process of making the polypeptides using those polynucleotides and vectors, and processes using those polypeptides and polynucleotides.

摘要翻译： 本发明提供增加抗生素产生的分离和纯化的多肽，编码那些多肽的多核苷酸，含有这些多核苷酸的表达载体，用那些表达载体转化的宿主细胞，使用这些多核苷酸和载体制备多肽的方法，以及使用这些多肽 和多核苷酸。

公开(公告)号：US06420177B1

公开(公告)日：2002-07-16

申请号：US09153599

申请日：1998-09-15

申请人： J. Mark Weber ,  Minh B. Luu

发明人： J. Mark Weber ,  Minh B. Luu

IPC分类号： C12N1574

CPC分类号： C12N9/0071 ,  C12P19/62

摘要： The present invention relates to a method of improving the strain used for the production of erythromycin through the disruption of the melA gene.

摘要翻译： 本发明涉及通过破坏melA基因改进用于生产红霉素的菌株的方法。

公开(公告)号：US09367106B2

公开(公告)日：2016-06-14

申请号：US13542714

申请日：2012-07-06

申请人： Shareef F. Alshinnawi ,  Gary D. Cudak ,  Edward S. Suffern ,  J. Mark Weber

发明人： Shareef F. Alshinnawi ,  Gary D. Cudak ,  Edward S. Suffern ,  J. Mark Weber

IPC分类号： G06F9/00 ,  G06F9/24 ,  G06F15/177 ,  G06F1/22 ,  G06F1/18

CPC分类号： G06F1/22 ,  G06F1/18 ,  G06F1/183 ,  G06F1/184

摘要： A unit of information technology equipment (ITE), such as a compute node or a network switch, comprises a system board in communication with network connectors that selectively connect to a network interconnect, a gravity sensor for detecting a first orientation and a second orientation of the system board, and a basic input/output system (BIOS) in communication with the gravity sensor to receive a signal identifying whether the system board is in the first or second orientation. The ITE further comprises a network ASIC (application specific integrated circuit) that inverts the pinout of transmit and receive signals in the network connectors in response to a command from the BIOS indicating that the system board is in the second orientation. A system may comprise a first ITE in a first orientation that interlocks with a second ITE in a second orientation that is inverted 180 degrees from the first orientation.

摘要翻译： 诸如计算节点或网络交换机的信息技术设备（ITE）的单元包括与网络连接器通信的系统板，网络连接器选择性地连接到网络互连，重力传感器用于检测第一取向和第二取向 系统板和与重力传感器通信的基本输入/输出系统（BIOS），以接收识别系统板是处于第一还是第二方向的信号。 ITE还包括网络ASIC（专用集成电路），其响应于来自BIOS的来自BIOS的指示系统板处于第二方向的命令，反转网络连接器中的发送和接收信号的引脚分布。 系统可以包括处于第一取向的第一ITE，其以与第一取向相反180度的第二取向互锁于第二ITE。

公开(公告)号：US06350591B1

公开(公告)日：2002-02-26

申请号：US09250585

申请日：1999-02-16

申请人： J. Mark Weber ,  David C. Demirjian ,  Malcolm J. Casadaban ,  Veronika Vonstein ,  Nikos C. Pagratis

发明人： J. Mark Weber ,  David C. Demirjian ,  Malcolm J. Casadaban ,  Veronika Vonstein ,  Nikos C. Pagratis

IPC分类号： C12N1574

CPC分类号： C12N9/0006 ,  C12N9/1077 ,  C12N15/74 ,  C12N15/902

摘要： We have developed a new gene transfer system for extreme thermophiles of the genus Thermus, including Thermus flavus., using a chromosomal gene, and a thermostable derivative of the kanamycin-resistance gene (kantr2). A plasmid mediated gene-replacement process is used to insert it into the chromosome resulting in the production of Leu−Kmr transformants. This system not only allows stable, single-copy gene insertion into the chromosome of an extreme thermophile, but can be used in the thermo-genetic process described here to generate thermo-stabilized enzymes and proteins for industrial processes. This host-vector environment makes it possible to generate further thermo-stabilizing mutations in the kan gene beyond those levels previously reported.

摘要翻译： 我们开发了一种新的基因转移系统，用于嗜热栖热菌（Thermus）的嗜热菌（Thermus flavus），使用染色体基因，以及卡那霉素抗性基因（kantr2）的热稳定衍生物。 使用质粒介导的基因置换方法将其插入染色体，导致产生Leu-Kmr转化体。 该系统不仅允许稳定的单拷贝基因插入到极端嗜热菌的染色体中，而且可用于本文所述的热遗传过程中以产生用于工业过程的热稳定的酶和蛋白质。 这种宿主载体环境使得可能在以前报道的那些水平之外在kan基因中产生进一步的热稳定突变。

公开(公告)号：US5872238A

公开(公告)日：1999-02-16

申请号：US912794

申请日：1997-08-18

申请人： J. Mark Weber ,  David C. Demirjian ,  Malcolm J. Casadaban ,  Veronika Vonstein ,  Nikos C. Pagratis

发明人： J. Mark Weber ,  David C. Demirjian ,  Malcolm J. Casadaban ,  Veronika Vonstein ,  Nikos C. Pagratis

IPC分类号： C12N9/04 ,  C12N9/10 ,  C12N15/31 ,  C12N15/74 ,  C12N15/90

CPC分类号： C12N9/0006 ,  C12N15/74 ,  C12N15/902 ,  C12N9/1077

摘要： We have developed a new gene transfer system for extreme thermophiles of the genus Thermus, including Thermus flavus., using a chromosomal gene, and a thermostable derivative of the kanamycin-resistance gene (kan.sup.tr2). A plasmid mediated gene-replacement process is used to insert it into the chromosome resulting in the production of Leu.sup.- Km.sup.r transformants. This system not only allows stable, single-copy gene insertion into the chromosome of an extreme thermophile, but can be used in the thermo-genetic process described here to generate thermo-stabilized enzymes and proteins for industrial processes. This host-vector environment makes it possible to generate further thermo-stabilizing mutations in the kan gene beyond those levels previously reported.

摘要翻译： 我们开发了一种新的基因转移系统，用于嗜热栖热菌（Thermus）的嗜热菌（Thermus flavus），使用染色体基因，以及卡那霉素抗性基因（kantr2）的热稳定衍生物。 使用质粒介导的基因替换过程将其插入染色体，导致Leu- Kmr转化体的产生。 该系统不仅允许稳定的单拷贝基因插入到极端嗜热菌的染色体中，而且可用于本文所述的热遗传过程中以产生用于工业过程的热稳定的酶和蛋白质。 这种宿主载体环境使得可能在以前报道的那些水平之外在kan基因中产生进一步的热稳定突变。

公开(公告)号：US08830672B2

公开(公告)日：2014-09-09

申请号：US13560617

申请日：2012-07-27

申请人： Shareef F. Alshinnawi ,  Gary D. Cudak ,  Christopher J. Hardee ,  Randall C. Humes ,  Adam Roberts ,  Edward S. Suffern ,  J. Mark Weber

发明人： Shareef F. Alshinnawi ,  Gary D. Cudak ,  Christopher J. Hardee ,  Randall C. Humes ,  Adam Roberts ,  Edward S. Suffern ,  J. Mark Weber

IPC分类号： G06F1/20 ,  H05K7/20

CPC分类号： G06F1/20 ,  H05K7/20 ,  H05K7/20736 ,  H05K7/20772

摘要： A computer system includes a rack-mountable server unit with a closed server housing. The server housing has a channel with a recessed channel wall in conductive thermal communication with a processor or other heat-generating component. An elongate conduit is received into the channel of the server housing in conductive thermal communication with an external surface of the server housing. The server is cooled by conductive fluid flow through the conduit, with no appreciable airflow through the server housing. The system may be operated in an optional burst cooling mode, wherein a volume of cooling fluid is trapped in the conduit for a period of time before being quickly released.

摘要翻译： 计算机系统包括具有封闭的服务器外壳的可机架安装的服务器单元。 服务器壳体具有通道，其具有与处理器或其它发热部件导电热连通的凹陷通道壁。 细长的管道被容纳在与服务器壳体的外表面导电热连通的服务器壳体的通道中。 服务器由导电流体流经管道冷却，没有明显的气流穿过服务器外壳。 系统可以以可选的突发冷却模式操作，其中在快速释放之前将一定体积的冷却流体捕获在管道中一段时间​​。

公开(公告)号：US20140029193A1

公开(公告)日：2014-01-30

申请号：US13560617

申请日：2012-07-27

申请人： Shareef F. Alshinnawi ,  Gary D. Cudak ,  Christopher J. Hardee ,  Randall C. Humes ,  Adam Roberts ,  Edward S. Suffern ,  J. Mark Weber

发明人： Shareef F. Alshinnawi ,  Gary D. Cudak ,  Christopher J. Hardee ,  Randall C. Humes ,  Adam Roberts ,  Edward S. Suffern ,  J. Mark Weber

IPC分类号： G06F1/20

CPC分类号： G06F1/20 ,  H05K7/20 ,  H05K7/20736 ,  H05K7/20772

摘要： A computer system includes a rack-mountable server unit with a closed server housing. The server housing has a channel with a recessed channel wall in conductive thermal communication with a processor or other heat-generating component. An elongate conduit is received into the channel of the server housing in conductive thermal communication with an external surface of the server housing. The server is cooled by conductive fluid flow through the conduit, with no appreciable airflow through the server housing. The system may be operated in an optional burst cooling mode, wherein a volume of cooling fluid is trapped in the conduit for a period of time before being quickly released.

摘要翻译： 计算机系统包括具有封闭的服务器外壳的可机架安装的服务器单元。 服务器壳体具有通道，其具有与处理器或其它发热部件导电热连通的凹陷通道壁。 细长的管道被容纳在与服务器壳体的外表面导电热连通的服务器壳体的通道中。 服务器由导电流体流经管道冷却，没有明显的气流穿过服务器外壳。 系统可以以可选的突发冷却模式操作，其中在快速释放之前将一定体积的冷却流体捕获在管道中一段时间​​。

公开(公告)号：US08553578B2

公开(公告)日：2013-10-08

申请号：US13042563

申请日：2011-03-08

申请人： Shareef F. Alshinnawi ,  John J. Struble, Jr. ,  Edward S. Suffern ,  J. Mark Weber

发明人： Shareef F. Alshinnawi ,  John J. Struble, Jr. ,  Edward S. Suffern ,  J. Mark Weber

IPC分类号： G06F13/00

CPC分类号： G06F13/128 ,  G06F13/387

摘要： A networking system includes a host adapter card including a card connector having four transceiver pairs and a mechanical connector configuration, and a controller having control logic for detecting whether a single-channel connection or a four-channel connection is made to the card connector. The controller further includes control logic for communicating over a network using a default, four-channel-protocol in response to detecting the four-channel connection or using an alternative, single-channel-protocol in response to detecting the single-channel connection. The system further includes an alternative-network compatibility device including a first connector configured for releasably mating with the card connector and a second connector having a different mechanical connector configuration than the card connector. The alternative-network compatibility device includes a transceiver lane from the first connector end to the second connector end, which transceiver lane is placed in connection with one of the four transceiver pairs when mated with the card connector.

摘要翻译： 网络系统包括主机适配器卡，其包括具有四个收发器对和机械连接器配置的卡连接器，以及具有用于检测是否对卡连接器进行单通道连接或四通道连接的控制逻辑的控制器。 控制器还包括用于响应于检测到四信道连接或使用替代的单信道协议来响应于检测到单信道连接而使用默认的四信道协议通过网络进行通信的控制逻辑。 该系统还包括替代网络兼容设备，其包括配置为可释放地与卡连接器配合的第一连接器和具有与卡连接器不同的机械连接器配置的第二连接器。 替代网络兼容设备包括从第一连接器端到第二连接器端的收发器通道，当与卡连接器配合时，该收发器通道与四个收发器对中的一个放置在一起。

公开(公告)号：US20130115869A1

公开(公告)日：2013-05-09

申请号：US13289435

申请日：2011-11-04

申请人： Shareef F. Alshinnawi ,  Robert W. Stegner ,  Edward S. Suffern ,  J. Mark Weber

发明人： Shareef F. Alshinnawi ,  Robert W. Stegner ,  Edward S. Suffern ,  J. Mark Weber

IPC分类号： H05K5/02 ,  F24F7/00 ,  F24F13/02

CPC分类号： H05K7/20736

摘要： A user-customizable air guide comprises a duct having four side panels, an open front end, an open back end, and a flange extending from at least two of the side panels at the front end. The four side panels have a plurality of frangible links that are generally parallel and spaced apart along the rectangular duct between the front end and the back end, wherein each frangible link extends around the four side panels of the rectangular duct. The frangible links are manually breakable to customize the length of the duct extending from the open front end.

摘要翻译： 用户可定制的空气引导件包括具有四个侧板，敞开的前端，敞开的后端以及从前端的至少两个侧板延伸的凸缘的管道。 四个侧板具有多个易碎连杆，它们在前端和后端之间沿着矩形管道大致平行且间隔开，其中每个易碎连杆围绕矩形管道的四个侧板延伸。 易碎的链接是手动破坏的，以便定制从开放的前端延伸的管道的长度。

公开(公告)号：US20130042778A1

公开(公告)日：2013-02-21

申请号：US13213128

申请日：2011-08-19

申请人： Shareef F. Alshinnawi ,  Margaret M. Quinn ,  Edward S. Suffern ,  J. Mark Weber

发明人： Shareef F. Alshinnawi ,  Margaret M. Quinn ,  Edward S. Suffern ,  J. Mark Weber

IPC分类号： B41F33/00 ,  B41J11/44

CPC分类号： B41J11/0095 ,  B41J11/008

摘要： A method of printing on a sheet of paper comprises drawing a first sheet of paper from a first paper source into a printer having an optical scanner and a print head, scanning a first face of the first sheet to determine the presence or absence of print thereon. In response to detecting print on the first face, the print head is caused to print an obstruction on the first face. In response to detecting no print on the first face, the print head is caused to print new matter on the first face. The method enables a printer to accept used paper while eliminating confusion over which face contains the new matter.

摘要翻译： 一种在一张纸上打印的方法包括将第一张纸从第一纸张来源拉入具有光学扫描仪和打印头的打印机中，扫描第一张纸的第一面以确定其上是否有印刷 。 响应于检测到第一面上的打印，使得打印头在第一面上印刷障碍物。 响应于在第一面上没有检测到打印，使打印头在第一面上印刷新物质。 该方法使得打印机能够接受使用过的纸张，同时消除对包含新物质的面部的混淆。