公开(公告)号：US07981597B2

公开(公告)日：2011-07-19

申请号：US11898655

申请日：2007-09-13

Applicant: Jürgen Patzke

Inventor： Jürgen Patzke

IPC: C12Q1/00 ,  C12Q1/56 ,  G01N33/554

CPC classification number: G01N33/554 ,  C12N5/0644 ,  G01N33/86 ,  G01N2333/755

Abstract: The present invention relates to a method for preparing agglutinatable platelet fragments, in which native platelets are treated with ultrasound and a fixative. The platelet fragments are suitable for use in diagnostic assay methods which include an agglutination reaction, such as, for example, in a method for determining VWF activity.

Abstract translation: 本发明涉及一种制备可凝集血小板片段的方法，其中天然血小板用超声和固定剂治疗。 血小板片段适用于包括凝集反应的诊断测定方法，例如在用于测定VWF活性的方法中。

公开(公告)号：US08178309B2

公开(公告)日：2012-05-15

申请号：US13106183

申请日：2011-05-12

Applicant: Jürgen Patzke

Inventor： Jürgen Patzke

IPC: G01N33/567 ,  G01N33/564

CPC classification number: G01N33/554 ,  C12N5/0644 ,  G01N33/86 ,  G01N2333/755

Abstract: The present invention relates to a method for preparing agglutinatable platelet fragments, in which native platelets are treated with ultrasound and a fixative. The platelet fragments are suitable for use in diagnostic assay methods which include an agglutination reaction, such as, for example, in a method for determining VWF activity.

Abstract translation: 本发明涉及一种制备可凝集血小板片段的方法，其中天然血小板用超声和固定剂治疗。 血小板片段适用于包括凝集反应的诊断测定方法，例如在用于测定VWF活性的方法中。

公开(公告)号：US06773923B2

公开(公告)日：2004-08-10

申请号：US09809062

申请日：2001-03-16

Applicant: Jürgen Patzke

Inventor： Jürgen Patzke

IPC: G01N3386

CPC classification number: G01N33/86 ,  G01N33/80

Abstract: The invention relates to a method for measuring the aggregation or agglutination of platelets, where a reaction mixture is mixed in a first reaction phase, and is mixed less vigorously or not at all in a second reaction phase following the first, and the measurement is preferably carried out in the second reaction phase.

Abstract translation: 本发明涉及一种用于测量血小板聚集或凝集的方法，其中反应混合物在第一反应相中混合，并且在第一反应阶段之后的第二反应阶段中不太有力或不完全混合，并且测量优选 在第二反应阶段进行。

公开(公告)号：US06610291B2

公开(公告)日：2003-08-26

申请号：US09739649

申请日：2000-12-20

Applicant: Jürgen Patzke ,  Konrad Braun

Inventor： Jürgen Patzke ,  Konrad Braun

IPC: C12N500

CPC classification number: G01N33/80 ,  G01N33/86 ,  G01N2333/755

Abstract: The present invention relates to a ready-to-use ristocetin cofactor test reagent possessing long-term stability for use in coagulation tests.

Abstract translation: 本发明涉及具有长期稳定性用于凝血试验的即用型瑞斯托菌素辅因子试剂。

公开(公告)号：US06317702B1

公开(公告)日：2001-11-13

申请号：US09503152

申请日：2000-02-11

Applicant: Jürgen Patzke

Inventor： Jürgen Patzke

IPC: G01N3100

CPC classification number: G01N33/557

Abstract: The present invention relates to a method for instrument determination of measured variable L(t) which changes with time, the intention being to determine the maximum rate value of L(t) in a region with a linear reaction profile, and the time as well as the duration of the reaction time window being variable with the linear region and depending on the nature of the reaction and the reaction conditions. Specifically, the present invention relates to the determination of protein concentrations with the aid of light scatter, which is produced by specific antibodies, in homogeneous solutions. In particular, the invention relates to reactions which take place slowly and have a largely linear profile over a relatively long time, the rate of formation of antigen-antibody complexes in the linear section of the reaction (VMaxLin) being determined as the measured variable.

Abstract translation: 本发明涉及一种随时间变化的测量变量L（t）的仪器确定方法，其目的是确定具有线性反应曲线的区域中L（t）的最大速率值，以及时间 因为反应时间窗口的持续时间随线性区域而变化，并且取决于反应的性质和反应条件。 具体地，本发明涉及在均匀溶液中借助特异性抗体产生的光散射来测定蛋白质浓度。 特别地，本发明涉及缓慢发生并且在较长时间内具有很大线性分布的反应，将反应线性部分中的抗原 - 抗体复合物的形成速率（VMaxLin）确定为测量变量。