公开(公告)号：US20040219596A1

公开(公告)日：2004-11-04

申请号：US10861644

申请日：2004-06-04

Applicant: Intel Corporation

Inventor： Narayan Sundararajan ,  Andrew A. Berlin ,  Mineo Yamakawa ,  Valluri Rao

IPC: C12Q001/68 ,  G01N033/53 ,  G01N033/00

CPC classification number: B82Y30/00 ,  B82Y5/00 ,  C12Q1/6816 ,  G01N33/551 ,  G01N33/58 ,  Y10T436/23 ,  C12Q2565/601 ,  C12Q2563/155

Abstract: A novel device and method for characterization of molecules is provides that improves characterization accuracy by utilizing larger numbers of reactive molecules that are smaller or shorter in chain length for the analysis procedure. Modification of markers such as nanotubes form nanotube assemblies that are easily detected using a number of surface analysis devices such as AFM and STM. The novel method shown using carbon nanotubes to mark a signature on reactive molecules permits a larger distribution and smaller molecule size of reactive molecules used in characterization of a sample molecule. The modification of the carbon nanotubes allows the characterization procedure to detect the nanotube markers more easily, thus decreasing characterization errors, and allowing faster characterization speeds.

Abstract translation: 提供了用于表征分子的新型装置和方法，其通过利用较大数量的链长度较小或较短的分析过程来提高表征精度。 诸如纳米管之类的标记的修饰形成使用许多表面分析装置如AFM和STM容易检测的纳米管组件。 使用碳纳米管标记反应性分子上的标记的新颖方法允许用于表征样品分子的反应性分子更大的分布和更小的分子大小。 碳纳米管的修改允许表征过程更容易地检测纳米管标记，从而减少表征误差，并允许更快的表征速度。

公开(公告)号：US20040219072A1

公开(公告)日：2004-11-04

申请号：US10856372

申请日：2004-05-27

Applicant: INTEL CORPORATION

Inventor： Mineo Yamakawa ,  John Heck ,  Selena Chan ,  Narayan Sundararajan

IPC: B01L003/00

CPC classification number: B01L3/502715 ,  B01J2219/00639 ,  B01L3/50255 ,  B01L3/502753 ,  B01L2300/0636 ,  B01L2300/0681 ,  B01L2300/0887 ,  B81B2201/0214 ,  Y10T137/2224

Abstract: Microfluidic apparatus including integrated porous substrate/sensors that may be used for detecting targeted biological and chemical molecules and compounds. In one aspect, upper and lower microfluidic channels are defined in respective halves of a substrate, which are sandwiched around a porous membrane upon assembly. In other aspect, the upper and lower channels are formed such that a portion of the lower channel passes beneath a portion of the upper channel to form a cross-channel area, wherein the membrane is disposed between the two channels. In various embodiments, one or more porous membranes are disposed proximate to corresponding cross-channel areas defined by one or more upper and lower channels. The porous membrane may also have sensing characteristics, such that it produces a change in an optical and/or electronic characteristic. Accordingly, the apparatus may further include instrumentation or detection equipment to measure the changes, such as optic-based detectors and electronic instrumentation.

Abstract translation: 微流体设备包括可用于检测目标生物和化学分子和化合物的综合多孔底物/传感器。 在一个方面，上和下微流体通道限定在基底的相应的两半中，其在组装时夹在多孔膜周围。 在另一方面，上通道和下通道形成为使得下通道的一部分穿过上通道的一部分以形成交叉通道区域，其中隔膜设置在两个通道之间。 在各种实施例中，一个或多个多孔膜设置在由一个或多个上部和下部通道限定的相应交叉通道区域附近。 多孔膜也可以具有感测特性，使得其产生光学和/或电子特性的变化。 因此，该装置还可以包括用于测量变化的仪器或检测设备，例如基于光学的检测器和电子仪器。

公开(公告)号：US20030148289A1

公开(公告)日：2003-08-07

申请号：US10067029

申请日：2002-02-04

Applicant: Intel Corporation

Inventor： Narayan Sundararajan ,  Andrew A. Berlin ,  Mineo Yamakawa ,  Valluri Rao

IPC: C12Q001/68 ,  G01N033/551

CPC classification number: B82Y30/00 ,  B82Y5/00 ,  C12Q1/6816 ,  G01N33/551 ,  G01N33/58 ,  Y10T436/23 ,  C12Q2565/601 ,  C12Q2563/155

Abstract: A novel device and method for characterization of molecules is provides that improves characterization accuracy by utilizing larger numbers of reactive molecules that are smaller or shorter in chain length for the analysis procedure. Modification of markers such as nanotubes form nanotube assemblies that are easily detected using a number of surface analysis devices such as AFM and STM. The novel method shown using carbon nanotubes to mark a signature on reactive molecules permits a larger distribution and smaller molecule size of reactive molecules used in characterization of a sample molecule. The modification of the carbon nanotubes allows the characterization procedure to detect the nanotube markers more easily, thus decreasing characterization errors, and allowing faster characterization speeds.

Abstract translation: 提供了用于表征分子的新型装置和方法，其通过利用较大数量的链长度较小或较短的分析过程来提高表征精度。 诸如纳米管之类的标记的修饰形成使用许多表面分析装置如AFM和STM容易检测的纳米管组件。 使用碳纳米管标记反应性分子上的标记的新颖方法允许用于表征样品分子的反应性分子更大的分布和更小的分子大小。 碳纳米管的修改允许表征过程更容易地检测纳米管标记，从而减少表征误差，并允许更快的表征速度。