公开(公告)号：US20030148289A1

公开(公告)日：2003-08-07

申请号：US10067029

申请日：2002-02-04

Applicant: Intel Corporation

Inventor： Narayan Sundararajan ,  Andrew A. Berlin ,  Mineo Yamakawa ,  Valluri Rao

IPC: C12Q001/68 ,  G01N033/551

CPC classification number: B82Y30/00 ,  B82Y5/00 ,  C12Q1/6816 ,  G01N33/551 ,  G01N33/58 ,  Y10T436/23 ,  C12Q2565/601 ,  C12Q2563/155

Abstract: A novel device and method for characterization of molecules is provides that improves characterization accuracy by utilizing larger numbers of reactive molecules that are smaller or shorter in chain length for the analysis procedure. Modification of markers such as nanotubes form nanotube assemblies that are easily detected using a number of surface analysis devices such as AFM and STM. The novel method shown using carbon nanotubes to mark a signature on reactive molecules permits a larger distribution and smaller molecule size of reactive molecules used in characterization of a sample molecule. The modification of the carbon nanotubes allows the characterization procedure to detect the nanotube markers more easily, thus decreasing characterization errors, and allowing faster characterization speeds.

Abstract translation: 提供了用于表征分子的新型装置和方法，其通过利用较大数量的链长度较小或较短的分析过程来提高表征精度。 诸如纳米管之类的标记的修饰形成使用许多表面分析装置如AFM和STM容易检测的纳米管组件。 使用碳纳米管标记反应性分子上的标记的新颖方法允许用于表征样品分子的反应性分子更大的分布和更小的分子大小。 碳纳米管的修改允许表征过程更容易地检测纳米管标记，从而减少表征误差，并允许更快的表征速度。

公开(公告)号：US20040219596A1

公开(公告)日：2004-11-04

申请号：US10861644

申请日：2004-06-04

Applicant: Intel Corporation

Inventor： Narayan Sundararajan ,  Andrew A. Berlin ,  Mineo Yamakawa ,  Valluri Rao

IPC: C12Q001/68 ,  G01N033/53 ,  G01N033/00

CPC classification number: B82Y30/00 ,  B82Y5/00 ,  C12Q1/6816 ,  G01N33/551 ,  G01N33/58 ,  Y10T436/23 ,  C12Q2565/601 ,  C12Q2563/155

Abstract: A novel device and method for characterization of molecules is provides that improves characterization accuracy by utilizing larger numbers of reactive molecules that are smaller or shorter in chain length for the analysis procedure. Modification of markers such as nanotubes form nanotube assemblies that are easily detected using a number of surface analysis devices such as AFM and STM. The novel method shown using carbon nanotubes to mark a signature on reactive molecules permits a larger distribution and smaller molecule size of reactive molecules used in characterization of a sample molecule. The modification of the carbon nanotubes allows the characterization procedure to detect the nanotube markers more easily, thus decreasing characterization errors, and allowing faster characterization speeds.

Abstract translation: 提供了用于表征分子的新型装置和方法，其通过利用较大数量的链长度较小或较短的分析过程来提高表征精度。 诸如纳米管之类的标记的修饰形成使用许多表面分析装置如AFM和STM容易检测的纳米管组件。 使用碳纳米管标记反应性分子上的标记的新颖方法允许用于表征样品分子的反应性分子更大的分布和更小的分子大小。 碳纳米管的修改允许表征过程更容易地检测纳米管标记，从而减少表征误差，并允许更快的表征速度。

公开(公告)号：US20040115654A1

公开(公告)日：2004-06-17

申请号：US10320041

申请日：2002-12-16

Applicant: Intel Corporation

Inventor： Valluri Rao ,  Mineo Yamakawa ,  Andrew A. Berlin

IPC: C12Q001/68 ,  B05D003/00 ,  C12M001/34

CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B01J2219/00441 ,  B01J2219/00527 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00689 ,  B01J2219/00711 ,  B01J2219/00722

Abstract: A method and apparatus for forming a polymer array on a substrate suitable for synthesizing polymer sequences. This includes forming an array, each location of the array having at least one strand end, forming photosensitive protection on the strand ends, and selectively scanning and modulating at least one energy beam to expose a pattern on the photosensitive protection. In some embodiments, the method further includes removing a protective group from selected strand ends based on the exposed pattern. The method then includes adding a predetermined one or more polymeric subunits to the deprotected strand ends. In some embodiments the photosensitive protection includes a layer of photoresist to cover the strand ends. Some embodiments use an ultra-violet laser.

Abstract translation: 一种在适于合成聚合物序列的基材上形成聚合物阵列的方法和装置。 这包括形成阵列，阵列的每个位置具有至少一个绞合端，在绞合端上形成感光保护，并且选择性地扫描和调制至少一个能量束以暴露感光保护上的图案。 在一些实施方案中，该方法还包括基于暴露图案从选定的链末端去除保护基团。 该方法然后包括将预定的一个或多个聚合物亚单位加入去保护的末端。 在一些实施例中，感光保护包括一层光致抗蚀剂以覆盖绞合端。 一些实施例使用紫外激光。