公开(公告)号：US11530218B2

公开(公告)日：2022-12-20

申请号：US17153065

申请日：2021-01-20

申请人： Incyte Corporation

发明人： Le Zhao ,  Xiaozhao Wang ,  Wenyu Zhu ,  Haolin Yin ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： C07D471/20 ,  C07D471/22 ,  C07D491/20 ,  C07D498/20

摘要： Disclosed are spirocyclic compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and treating cancer, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

公开(公告)号：US20210269434A1

公开(公告)日：2021-09-02

申请号：US17144374

申请日：2021-01-08

申请人： Incyte Corporation

发明人： Xiaozhao Wang ,  Wenyu Zhu ,  Jeffrey Yang ,  Alexander Sokolsky ,  Chunhong He ,  Zhenwu Li ,  Chao Qi ,  Yong Li ,  Pei Gan ,  Peter Carlsen ,  Gia Hoang ,  Heeoon Han ,  Chenyin Marshall Law ,  Fenglei Zhang ,  Padmaja Polam ,  Le Zhao ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： C07D471/04 ,  A61P35/00 ,  C07D519/00 ,  C07D471/14

摘要： Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

公开(公告)号：US20210061809A1

公开(公告)日：2021-03-04

申请号：US17002045

申请日：2020-08-25

申请人： Incyte Corporation

发明人： Heeoon Han ,  Le Zhao ,  Wenqing Yao ,  Xiaozhao Wang

IPC分类号： C07D487/04

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US20230226040A1

公开(公告)日：2023-07-20

申请号：US17991482

申请日：2022-11-21

申请人： Incyte Corporation

发明人： Alejandro Amador Arjona ,  Angela Abdollahi ,  Margaret Favata ,  Jonathan Rios-Doria ,  Hui Wang ,  Susan Wee ,  Pei Gan ,  Jeffrey C. Yang ,  Yong Li ,  Le Zhao ,  Chunhong He ,  Chunyin Marshall Law ,  Wenyu Zhu ,  Xiaozhao Wang ,  Wenqing Yao ,  Peter Niels Carlsen ,  Fenglei Zhang ,  Qinda Ye ,  Matthew S. McCammant ,  Rocco Policarpo ,  Artem Shvartsbart ,  Jeremy Roach ,  Gia Hoang ,  Bin Hu ,  Gencheng Li ,  Robert Susick ,  Padmaja Polam ,  Chao Qi ,  Alexander Sokolsky ,  Haolin Yin ,  Chang Min

IPC分类号： A61K31/4745 ,  A61P35/00 ,  A61P11/00 ,  A61K31/5377 ,  A61K31/519 ,  A61K31/498 ,  A61K31/506 ,  A61K45/06

CPC分类号： A61K31/4745 ,  A61P35/00 ,  A61P11/00 ,  A61K31/5377 ,  A61K31/519 ,  A61K31/498 ,  A61K31/506 ,  A61K45/06

摘要： The present disclosure relates to methods of treating cancer by administering a compound, which is a Fibroblast Growth Factor Receptor (FGFR) inhibitor, in combination with a Kirsten rat sarcoma (KRAS) inhibitor.

公开(公告)号：US11673894B2

公开(公告)日：2023-06-13

申请号：US17077713

申请日：2020-10-22

申请人： Incyte Corporation

发明人： Xiaozhao Wang ,  Pei Gan ,  Taisheng Huang ,  Chao Qi ,  Ding-Quan Qian ,  Liangxing Wu ,  Wenqing Yao ,  Zhiyong Yu ,  Fenglei Zhang ,  Le Zhao ,  Chunhong He

IPC分类号： C07D497/04 ,  C07D487/04 ,  C07D491/056 ,  C07D519/00 ,  A61P35/00 ,  A61P25/00 ,  A61P9/00 ,  A61P29/00

CPC分类号： C07D487/04 ,  A61P9/00 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  C07D491/056 ,  C07D519/00

摘要： This application relates to compounds of Formula (I):




or pharmaceutically acceptable salts or stereoisomers thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US11168089B2

公开(公告)日：2021-11-09

申请号：US16415610

申请日：2019-05-17

申请人： Incyte Corporation

发明人： Xiaozhao Wang ,  Heeoon Han ,  Matthew S. McCammant ,  Liangxing Wu ,  Wenqing Yao ,  Zhiyong Yu ,  Le Zhao

IPC分类号： C07D487/04 ,  C07D519/00

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US20230056631A1

公开(公告)日：2023-02-23

申请号：US17810915

申请日：2022-07-06

申请人： Incyte Corporation

发明人： Pei Gan ,  Jeffrey Yang ,  Yong Li ,  Le Zhao ,  Chunhong He ,  Chunyin Marshall Law ,  Xiaozhao Wang ,  Wenqing Yao

IPC分类号： C07D471/04 ,  A61P35/00

摘要： Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

公开(公告)号：US20210230162A1

公开(公告)日：2021-07-29

申请号：US17153065

申请日：2021-01-20

申请人： Incyte Corporation

发明人： Le Zhao ,  Xiaozhao Wang ,  Wenyu Zhu ,  Haolin Yin ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： C07D471/20 ,  C07D491/20 ,  C07D471/22 ,  C07D498/20

摘要： Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

公开(公告)号：US11873304B2

公开(公告)日：2024-01-16

申请号：US17159345

申请日：2021-01-27

申请人： Incyte Corporation

发明人： Xiaozhao Wang ,  Heeoon Han ,  Matthew S. McCammant ,  Liangxing Wu ,  Wenqing Yao ,  Zhiyong Yu ,  Le Zhao

IPC分类号： A61P35/00 ,  A61P35/04 ,  A61K31/519 ,  C07D487/04 ,  C07D519/00

CPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00 ,  A61P35/04 ,  C07D519/00

摘要： This application relates to compounds of Formula (I):




or pharmaceutically acceptable salts thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US20230357255A1

公开(公告)日：2023-11-09

申请号：US18300349

申请日：2023-04-13

申请人： Incyte Corporation

发明人： Xiaozhao Wang ,  Pei Gan ,  Taisheng Huang ,  Chao Qi ,  Ding-Quan Qian ,  Liangxing Wu ,  Wenqing Yao ,  Zhiyong Yu ,  Fenglei Zhang ,  Le Zhao ,  Chunhong He

IPC分类号： C07D487/04 ,  C07D491/056 ,  C07D519/00 ,  A61P35/00 ,  A61P25/00 ,  A61P9/00 ,  A61P29/00

CPC分类号： C07D487/04 ,  C07D491/056 ,  C07D519/00 ,  A61P35/00 ,  A61P25/00 ,  A61P9/00 ,  A61P29/00

摘要： This application relates to compounds of Formula (I):




or pharmaceutically acceptable salts or stereoisomers thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.