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公开(公告)号：US11845725B2
公开(公告)日：2023-12-19
申请号：US17946587
申请日：2022-09-16
发明人： Ian Cooper , David Orr , Andrew Wilkinson , Jonathan Finlayson , Adam Bunt , Pia Appelqvist , Hans Wallberg , Fredrik Wångsell
IPC分类号： C07D207/48 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/12 , A61P31/04 , C07D207/36 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/04 , C07D487/04
CPC分类号： C07D207/48 , A61P31/04 , C07D207/36 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D417/04 , C07D487/04
摘要： This invention relates to compounds of formula (I) and methods of treatment using the compounds. The compounds of the invention can be used in combination with antibacterial agents to treat bacterial infections. More specifically, the compounds of formula (I) can be used in combination with a class of antibacterial agents known as carbapenems. The novel compounds of the present invention are enzyme inhibitors and more particularly are metallo-β-lactamase inhibitors.
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公开(公告)号：US20210230115A1
公开(公告)日：2021-07-29
申请号：US17055506
申请日：2019-05-16
发明人： Ian Cooper , David ORR , Andrew Wilkinson , Jonathan Finlayson , Adam Bunt , Pia Appelqvist , Hans Wallberg , Fredrik Wångsell
IPC分类号： C07D207/48 , C07D403/04 , C07D401/04 , C07D401/10 , C07D403/14 , C07D207/36 , C07D401/14 , C07D487/04 , C07D417/04 , C07D403/12 , A61P31/04
摘要： This invention relates to compounds of formula (I) and methods of treatment using the compounds. The compounds of the invention can be used in combination with antibacterial agents to treat bacterial infections. More specifically, the compounds of formula (I) can be used in combination with a class of antibacterial agents known as carbapenems. The novel compounds of the present invention are enzyme inhibitors and more particularly are metallo-β-lactamase inhibitors.
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公开(公告)号：US11459296B2
公开(公告)日：2022-10-04
申请号：US17055506
申请日：2019-05-16
发明人： Ian Cooper , David Orr , Andrew Wilkinson , Jonathan Finlayson , Adam Bunt , Pia Appelqvist , Hans Wallberg , Fredrik Wångsell
IPC分类号： C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D207/48 , C07D403/04 , C07D403/12 , C07D403/14 , C07D487/04 , C07D417/04 , A61P31/04 , C07D207/36
摘要： This invention relates to compounds of formula (I) and methods of treatment using the compounds. The compounds of the invention can be used in combination with antibacterial agents to treat bacterial infections. More specifically, the compounds of formula (I) can be used in combination with a class of antibacterial agents known as carbapenems. The novel compounds of the present invention are enzyme inhibitors and more particularly are metallo-β-lactamase inhibitors.
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公开(公告)号：US20230060011A1
公开(公告)日：2023-02-23
申请号：US17946587
申请日：2022-09-16
发明人： Ian Cooper , David Orr , Andrew Wilkinson , Jonathan Finlayson , Adam Bunt , Pia Appelqvist , Hans Wallberg , Fredrik Wångsell
IPC分类号： C07D207/48 , A61P31/04 , C07D207/36 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D417/04 , C07D487/04 , C07D401/12
摘要： This invention relates to compounds of formula (I) and methods of treatment using the compounds. The compounds of the invention can be used in combination with antibacterial agents to treat bacterial infections. More specifically, the compounds of formula (I) can be used in combination with a class of antibacterial agents known as carbapenems. The novel compounds of the present invention are enzyme inhibitors and more particularly are metallo-β-lactamase inhibitors.
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公开(公告)号：US20230018460A1
公开(公告)日：2023-01-19
申请号：US17778261
申请日：2020-11-19
发明人： Andrew Wilkinson , Ian Cooper , David Orr , Jonathan Finlayson , Adam Bunt , Pia Appelqvist , Hans Wallberg , Fredrik Wångsell , James Kirkham
IPC分类号： A61K31/40 , A61K31/407 , A61K31/431 , A61K31/4162 , A61K31/427 , C07D207/48 , C07D401/12 , C07D403/12 , C07D487/10 , C07D401/04 , C07D403/04 , C07D401/06 , C07D401/14 , C07D471/08 , A61P31/04 , A61K31/454 , A61K31/4025 , A61K31/5377 , A61K31/4178 , A61K31/541 , A61K31/4439 , A61K31/496 , A61K31/438 , A61K31/403
摘要： This invention relates to compounds of formula (I) and methods of treatment using the compounds. The compounds of the invention can be used in combination with antibacterial agents to treat bacterial infections. More specifically, the compounds of formula (I) can be used in combination with a class of antibacterial agents known as carbapenems. The novel compounds of the present invention are enzyme inhibitors and more particularly are metallo-β-lactamase inhibitors.
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