公开(公告)号：US20240327927A1

公开(公告)日：2024-10-03

申请号：US18618857

申请日：2024-03-27

申请人： IMMUNIS.AI, Inc.

发明人： Amin I. Kassis ,  Geoffrey Erickson ,  Ricard Henao ,  Kirk Wojno ,  Harry Stylli ,  Leander Van Neste

IPC分类号： C12Q1/6886

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158

摘要： The present disclosure relates to compositions, methods, and systems useful for assessing whether a patient with prostate cancer is a candidate for active surveillance of the prostate cancer, as well as compositions, methods, and systems for assessing and identifying prostate cancer. The disclosure provides algorithm-based assays comprising subtraction-normalized immunocyte signature profiling from a sample obtained from a prostate cancer patient. Measurement of expression of signature markers identify on an individual basis, via an active surveillance risk score, prostate cancer patients that are to enter, continue, or stop an active surveillance pathway.

公开(公告)号：US20230280346A1

公开(公告)日：2023-09-07

申请号：US18171569

申请日：2023-02-20

申请人： IMMUNIS.AI, INC.

发明人： Amin I. Kassis ,  Harry Stylli ,  Colleen Kelly ,  Geoffrey Erickson ,  Kirk J. Wojno

IPC分类号： G01N33/574 ,  C12Q1/6886

CPC分类号： G01N33/57434 ,  C12Q1/6886 ,  G01N2800/52 ,  C12Q2600/158 ,  G01N2500/00 ,  G01N2333/90 ,  G01N2333/7158 ,  G01N2333/46 ,  C12Q2600/106 ,  C12Q2600/118 ,  G01N2500/04 ,  G01N2800/50 ,  G01N2800/54

摘要： The invention described herein provides biological markers for the diagnosis, prognosis, and monitoring of prostate cancer

公开(公告)号：US20240327930A1

公开(公告)日：2024-10-03

申请号：US18681604

申请日：2022-08-05

申请人： IMMUNIS.AI, INC.

发明人： Amin I. Kassis ,  Geoffrey Erickson ,  Kirk J. Wojno ,  Leander Van Neste ,  Ricardo Henao ,  Harry Stylli

IPC分类号： C12Q1/6886 ,  G01N33/50 ,  G01N33/569 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  G01N33/5047 ,  G01N33/56972 ,  G01N33/57434 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N2800/56

摘要： The present disclosure relates to compositions and methods for assessing prostate cancer (e.g., identification of the aggressiveness or indolence of prostate cancer) in a subject. The compositions and methods include obtaining subject specific information (e.g., age, digital rectal exam (DRE) data, prostate volume, prostate density, total prostate-specific antigen (PSA)) and obtaining a biological sample from a subject and determining a measurement for a panel of biomarkers in the biological sample. Compositions and methods of the disclosure find use in both clinical and research settings, for example, within the fields of biology, immunology, medicine, and oncology.

公开(公告)号：US12037645B2

公开(公告)日：2024-07-16

申请号：US16700777

申请日：2019-12-02

申请人： IMMUNIS.AI, INC.

发明人： Amin I. Kassis ,  Harry Stylli ,  Colleen Kelly ,  Geoffrey Erickson ,  Kirk J. Wonjo

IPC分类号： C12Q1/6886 ,  G01N33/50 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  G01N33/5023 ,  G01N33/5055 ,  G01N33/57407 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N2800/52 ,  G01N2800/60

摘要： This invention provides a set of biological markers that are useful for detecting cancer. This invention further provides methods of using those biological markers for the diagnosis, prognosis, or monitoring of cancer.

公开(公告)号：US11585814B2

公开(公告)日：2023-02-21

申请号：US14773599

申请日：2014-03-07

申请人： IMMUNIS.AI, INC.

发明人： Amin I. Kassis ,  Harry Stylli ,  Colleen Kelly ,  Geoffrey Erickson ,  Kirk J. Wojno

IPC分类号： C12Q1/6886 ,  G01N33/574

摘要： The invention described herein provides biological markers for the diagnosis, prognosis, and monitoring of prostate cancer.