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    Transfected T-cells and T-cell receptors for use in immunotherapy against cancers
    2.
    发明授权
    Transfected T-cells and T-cell receptors for use in immunotherapy against cancers 有权

    公开(公告)号：US10596242B2

    公开(公告)日：2020-03-24

    申请号：US16413939

    申请日：2019-05-16

    Applicant: Immatics Biotechnologies GmbH

    Inventor： Dominik Maurer ,  Leonie Alten ,  Sebastian Bunk

    IPC: C07K14/725 ,  A61K39/00 ,  A61K45/06 ,  C07K14/74 ,  G01N33/574 ,  C12N5/0783

    Abstract: The present description relates to T-cell receptors (TCRs) binding to tumor-associated antigens (TAAs) for targeting cancer cells, T-cells expressing same, methods for producing same, and methods for treating cancers using same. In particular, the present description relates to TCRs and their variants that bind to HLA class I or II molecules with a peptide, such as IGF2BP3-001 have the amino acid sequence of KIQEILTQV (SEQ ID NO:1). The present description further relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present description relates to the immunotherapy of cancer. The present description furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T-cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

    Transfected T-cells and T-cell receptors for use in immunotherapy against cancers
    3.
    发明授权
    Transfected T-cells and T-cell receptors for use in immunotherapy against cancers 有权

    公开(公告)号：US10538573B2

    公开(公告)日：2020-01-21

    申请号：US15460654

    申请日：2017-03-16

    Applicant: IMMATICS BIOTECHNOLOGIES GMBH

    Inventor： Dominik Maurer ,  Sebastian Bunk ,  Leonie Alten

    IPC: C07K14/725 ,  A61K38/00

    Abstract: Disclosed are T-cell receptors (TCRs) binding to tumor-associated antigens (TAAs) for targeting cancer cells, T-cells expressing same, methods for producing same, and methods for treating cancers using same. Disclosed are TCRs and their variants that bind to HLA class I or II molecules with a peptide, such as MAG-003 have the amino acid sequence of KVLEHVVRV (SEQ ID NO:1). The description further relates to peptides, proteins, nucleic acids, cells for use in immunotherapeutic methods, the immunotherapy of cancer, and tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T-cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

    T cell receptors and immune therapy using the same
    8.
    发明授权
    T cell receptors and immune therapy using the same 有权

    公开(公告)号：US11111294B2

    公开(公告)日：2021-09-07

    申请号：US16733845

    申请日：2020-01-03

    Applicant: Immatics Biotechnologies GmbH

    Inventor： Claudia Wagner ,  Leonie Alten ,  Sebastian Bunk ,  Dominik Maurer

    IPC: C07K14/725 ,  C07K16/26 ,  C07K14/81 ,  C07K16/28 ,  C07K16/38 ,  C12N5/0783 ,  C12N15/85

    Abstract: The present invention pertains to antigen recognizing constructs against tumor associated antigens (TAA), in particular the TAA Serine protease inhibitor Kazal-type 2 (SPINK2). The invention in particular provides novel T cell receptor (TCR) based molecules which are selective and specific for the tumor expressed antigen of the invention. The TCR of the invention, and SPINK2 binding fragments derived therefrom, are of use for the diagnosis, treatment and prevention of SPINK2 expressing cancerous diseases. Further provided are nucleic acids encoding the antigen recognizing constructs of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen recognizing constructs and pharmaceutical compositions comprising the compounds of the invention.

    Transfected T-cells and T-cell receptors for use in immunotherapy against cancers
    9.
    发明授权
    Transfected T-cells and T-cell receptors for use in immunotherapy against cancers 有权

    公开(公告)号：US10889629B2

    公开(公告)日：2021-01-12

    申请号：US16813248

    申请日：2020-03-09

    Applicant: IMMATICS BIOTECHNOLOGIES GMBH

    Inventor： Dominik Maurer ,  Sebastian Bunk ,  Leonie Alten

    IPC: C07K14/725 ,  A61K35/12 ,  A61K35/17 ,  C07K14/435 ,  C12N15/09 ,  C12N15/10 ,  A61K35/66 ,  A61K38/00

    Abstract: Disclosed are T-cell receptors (TCRs) binding to tumor-associated antigens (TAAs) for targeting cancer cells, T-cells expressing same, methods for producing same, and methods for treating cancers using same. Disclosed are TCRs and their variants that bind to HLA class I or II molecules with a peptide, such as MAG-003 have the amino acid sequence of KVLEHVVRV (SEQ ID NO:1). The description further relates to peptides, proteins, nucleic acids, cells for use in immunotherapeutic methods, the immunotherapy of cancer, and tmor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T-cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

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