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公开(公告)号：US11369275B2
公开(公告)日：2022-06-28
申请号：US16709908
申请日：2019-12-10
申请人： IMEC VZW , STICHTING IMEC NEDERLAND
IPC分类号： A61B5/0295 , A61B5/0205 , A61B5/1455 , A61B5/00 , A61B5/024
摘要： A device for read-out of a photoplethysmography (PPG) signal comprises: a photodiode, which is configured to detect a PPG signal, the photodiode comprising a first and a second terminal; and a read-out circuitry for reading out the PPG signal, wherein an input stage is connected to receive a first and a second input signal from the terminals and a DC bias voltage, and wherein the input stage is configured for current sensing to provide a fully differential amplification of the input signals to a first and a second current signal, and wherein an output stage is configured to receive the current signals, wherein the current signals comprise an AC and a DC component of the PPG signal, and wherein the output stage is configured to generate a differential output voltage through a gain component.
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公开(公告)号：US11864876B2
公开(公告)日：2024-01-09
申请号：US16886714
申请日：2020-05-28
发明人： Qiuyang Lin , Jiawei Xu , Shuang Song , Nick Van Helleputte , Filip Tavernier
CPC分类号： A61B5/02427 , A61B5/0042 , A61B5/0075 , A61B5/6826 , G01J1/44 , G01J2001/446
摘要： A light-to-digital converter (2) comprises a light-to-current converter (10); a current integrator (4) with an integrator output (30) resettable to a baseline level; and a counter (18) with a digital output (26), wherein the light-to-current converter (10) is switchably connectable as a positive integration input to the current integrator (4), for, during a light-collecting phase (404-406), integrating a current from the light-to-current converter (10), the integrator output (30) starting from the baseline value and ending at a value to be digitized; a reference current source (14) is switchably connectable as a negative integration input to the current integrator (4), for, during a counting phase (406-408) subsequent to the light-collecting phase (404-406), integrating a reference current from the reference current source (14), the integrator output (30) starting from the value to be digitized and ending at the baseline value, the time spent integrating the reference current corresponding to the value to be digitized; and the counter (18) is configured for measuring the time.
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公开(公告)号：US11689209B2
公开(公告)日：2023-06-27
申请号：US17590211
申请日：2022-02-01
IPC分类号： H03M1/06
CPC分类号： H03M1/0604
摘要： An analog-to-digital converter, ADC, circuitry, comprises: an integrator connected to a capacitor, the integrator being configured to switch between integrating an analog input signal for ramping an integrator output and integrating a reference input signal for returning integrator output towards a threshold; a comparator for comparing integrator output to the threshold; and a timer for determining a time duration during which the reference input signal is integrated, the time duration providing a digital representation of an analog input signal value; the ADC circuitry further comprising a feedforward noise shaping loop configured to store a quantization error signal based on digitizing a first sample, the comparator being configured to receive a feedforward noise shaping signal for changing the threshold for digitizing a later sample of the analog input signal following the first sample.
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公开(公告)号：US11559220B2
公开(公告)日：2023-01-24
申请号：US16784235
申请日：2020-02-06
申请人： IMEC VZW , STICHTING IMEC NEDERLAND
发明人： Hyunsoo Ha , Nick Van Helleputte
IPC分类号： A61B5/053 , A61B5/0245 , A61B5/08 , A61B5/00
摘要： A measurement unit for measuring a bio-impedance of a body, the measurement unit comprising a current generator circuit, a readout circuit, and a baseline cancellation current circuit, wherein the current generator circuit is configured to amplify a reference current to form a measurement current to be driven through a body to generate a measurement voltage representing the bio-impedance; wherein the readout circuit comprises a Instrumentation amplifier (IA) which has a transconductance stage and a transimpedance stage, wherein the IA is configured to: produce a first current in the transconductance stage, the first current being proportional to the measurement voltage, receive a second current from the baseline cancellation current circuit, produce an output voltage in the transimpedance stage, the output voltage being proportional to a difference between the first current and the second current and representative of the measured bio-impedance; wherein the baseline cancellation current circuit is configured to amplify the reference current by a factor to form the second current and deliver it to the IA, wherein the factor is such that that the absolute value of the difference between the first and the second current is below a threshold such that a baseline of the first current is cancelled by the second current.
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公开(公告)号：US11576623B2
公开(公告)日：2023-02-14
申请号：US16716991
申请日：2019-12-17
发明人： Dwaipayan Biswas , Luke Everson , Mario Konijnenburg , Christiaan Van Hoof , Nick Van Helleputte
摘要： A method of generating a model for generating a synthetic electrocardiography (ECG) signal comprises: receiving subject-specific training data for machine learning, said training data comprising a photoplethysmography (PPG) signal acquired from the subject and an ECG signal acquired from the subject, wherein the ECG signal provides a ground truth of the subject for associating the ECG signal with the PPG signal; using associated pairs of a time-series of the PPG signal and a corresponding time-series of the ECG signal as input to a deep neural network, DNN; and determining, through the DNN, a subject-specific model relating the PPG signal of the subject to the ECG signal of the subject for converting the PPG signal to a synthetic ECG signal using the subject-specific model.
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公开(公告)号：US20220015712A1
公开(公告)日：2022-01-20
申请号：US17376543
申请日：2021-07-15
申请人： IMEC VZW , Stichting IMEC Nederland
摘要： The disclosure includes a biosignal monitoring system for reducing a motion artifact from a biopotential electrical signal input, including a signal processing module, a motion artifact extraction module, and a subtraction module. The motion artifact extraction module and the signal processing module receive the biopotential electrical signal input and the subtraction module receives an extracted signal from an output of the motion artifact extraction module and a biopotential electrical signal from an output of the signal processing module. The subtraction module subtracts the extracted signal from the biopotential electrical signal. The motion artifact extraction module is an analog domain electronic circuit and includes a filter network configured for attenuating differential mode signals of the biopotential electrical signal input from a first frequency, and passing the motion artifact signal from the biopotential electrical signal input up to a second frequency at the output of the motion artifact extraction module.
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7.发明授权System and method for acquisition of biopotential signals with motion artifact reduction 有权用于获取生物电位信号的运动神经减影的系统和方法公开(公告)号：US09375182B2
公开(公告)日：2016-06-28
申请号：US14573714
申请日：2014-12-17
申请人： IMEC VZW
IPC分类号： A61B5/04 , A61B5/00 , A61B5/0428 , A61B5/0402
CPC分类号： A61B5/7207 , A61B5/04017 , A61B5/0402 , A61B5/0428 , A61B5/7214 , A61B5/7246
摘要： A biopotential signal acquisition system including an analog readout unit configured to receive an analog biopotential signal, which may be acquired from at least one electrode attached to a body; and to extract an analog measured biopotential signal and an analog reference signal. The system also includes an ADC unit configured to provide a digital version of the analog measured biopotential signal and the analog reference signal, a digital filter unit configured to calculate a digital motion artifact estimate based on the digital version of the measured biopotential signal and the reference signal. The system further comprises a reference signal processing unit configured to convert the reference signal into a new reference signal being provided to the digital filter unit based on the correlation between the measured biopotential signal and the reference signal.
摘要翻译： 生物电位信号采集系统，包括被配置为接收模拟生物电位信号的模拟读出单元，模拟生物电位信号可以从附着于身体的至少一个电极获取; 并提取模拟测量的生物电位信号和模拟参考信号。 该系统还包括被配置为提供模拟测量生物电位信号和模拟参考信号的数字版本的ADC单元，数字滤波器单元，被配置为基于测量的生物电位信号和参考的数字版本来计算数字运动伪影估计 信号。 该系统还包括参考信号处理单元，其被配置为基于所测量的生物电位信号和参考信号之间的相关性将参考信号转换为提供给数字滤波器单元的新参考信号。
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8.发明申请System and Method for Acquisition of Biopotential Signals with Motion Artifact Reduction in Real Time Operation 有权用于实时运算减少运动神经元的生物电位信号采集系统和方法公开(公告)号：US20150216481A1
公开(公告)日：2015-08-06
申请号：US14615150
申请日：2015-02-05
申请人： IMEC VZW
IPC分类号： A61B5/00 , A61B5/0488 , A61B5/0476 , A61B5/0402 , A61B5/04
CPC分类号： A61B5/7207 , A61B5/04012 , A61B5/04017 , A61B5/0402 , A61B5/0476 , A61B5/0488 , A61B5/7214
摘要： A biopotential signal acquisition system comprising an analogue readout unit configured to receive an analogue biopotential signal and to extract an analogue measured biopotential signal and an analogue reference signal, and an ADC unit configured to provide a digital version of the analogue measured biopotential signal and the analogue reference signal. The system also includes a first digital filter unit comprising a cascaded integrator-comb filter configured to provide a first digital filtered version of the digital measured biopotential signal and the reference signal, and a second digital filter unit configured to calculate a digital motion artifact estimate based on the first digital filtered version signals.
摘要翻译： 生物电位信号采集系统，包括模拟读出单元，其被配置为接收模拟生物电位信号并提取模拟测量的生物电位信号和模拟参考信号，以及ADC单元，被配置为提供所述模拟测量生物电位信号和模拟 参考信号。 该系统还包括第一数字滤波器单元，其包括级联的积分器梳状滤波器，其被配置为提供数字测量的生物电位信号和参考信号的第一数字滤波版本，以及第二数字滤波器单元，被配置为基于数字滤波器单元 在第一个数字滤波版本信号上。
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公开(公告)号：US20240218441A1
公开(公告)日：2024-07-04
申请号：US18397221
申请日：2023-12-27
申请人： IMEC VZW
IPC分类号： C12Q1/6869 , C12Q1/6825
CPC分类号： C12Q1/6869 , C12Q1/6825
摘要： The present disclosure relates to single-peptide sequencing. A method for sequencing peptides is provided that includes attaching a base end of a peptide to a channel region surface of a biosensor field effect transistor (bio-FET) and obtaining a first measurement of a parameter of the bio-FET, the parameter depending on the bio-FET's threshold voltage. The method further includes providing first molecular probes into the electrolyte gate, each first molecular probe being linked to a respective charge tag, and obtaining a second measurement of the parameter. Then, the method includes determining whether a shift of the parameter occurred between the first and second measurements, which indicates that a first molecular probe attached to an amino acid at a free end of the peptide. If the shift of the parameter occurred, the method includes determining a type of the amino acid based on a type of the first molecular probe.
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10.发明授权System and method for acquisition of biopotential signals with motion artifact reduction in real time operation 有权用于在实时操作中获取具有运动伪影的生物电位信号的系统和方法公开(公告)号：US09326733B2
公开(公告)日：2016-05-03
申请号：US14615150
申请日：2015-02-05
申请人： IMEC VZW
IPC分类号： A61B5/04 , A61B5/00 , A61B5/0402 , A61B5/0476 , A61B5/0488
CPC分类号： A61B5/7207 , A61B5/04012 , A61B5/04017 , A61B5/0402 , A61B5/0476 , A61B5/0488 , A61B5/7214
摘要： A biopotential signal acquisition system comprising an analog readout unit configured to receive an analog biopotential signal and to extract an analog measured biopotential signal and an analog reference signal, and an ADC unit configured to provide a digital version of the analog measured biopotential signal and the analog reference signal. The system also includes a first digital filter unit comprising a cascaded integrator-comb filter configured to provide a first digital filtered version of the digital measured biopotential signal and the reference signal, and a second digital filter unit configured to calculate a digital motion artifact estimate based on the first digital filtered version signals.
摘要翻译： 生物电位信号采集系统，包括模拟读出单元，其被配置为接收模拟生物电位信号并提取模拟测量的生物电位信号和模拟参考信号;以及ADC单元，被配置为提供模拟测量的生物电位信号的数字版本和模拟 参考信号。 该系统还包括第一数字滤波器单元，其包括级联的积分器梳状滤波器，其被配置为提供数字测量的生物电位信号和参考信号的第一数字滤波版本，以及第二数字滤波器单元，被配置为基于数字滤波器单元 在第一个数字滤波版本信号。
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