公开(公告)号：US20190183912A1

公开(公告)日：2019-06-20

申请号：US16327631

申请日：2017-08-22

Applicant: Merck Sharp & Dohme Corp. ,  IDENIX PHARMACEUTICALS LLC

Inventor： Daniel Da Costa ,  Cyril B. Dousson ,  David Dukhan ,  Jean-Laurent Paparin ,  Houcine Rahali ,  Izzat Raheem

IPC: A61K31/675 ,  A61P31/12

CPC classification number: A61K31/675 ,  A61K45/05 ,  A61K45/06 ,  A61P31/00 ,  A61P31/12 ,  C07F9/65616

Abstract: Compounds of Formula I: and pharmaceutically acceptable salts and co-crystals thereof are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.

公开(公告)号：US10717758B2

公开(公告)日：2020-07-21

申请号：US15981813

申请日：2018-05-16

Applicant: IDENIX PHARMACEUTICALS LLC

Inventor： Benjamin Alexander Mayes ,  Adel M. Moussa ,  Alistair James Stewart ,  David Dukhan

IPC: C07H19/20 ,  A61K31/403 ,  C07H19/10 ,  A61K31/7072 ,  A61K45/06 ,  A61K31/7076 ,  A61K31/708 ,  A61K31/4709 ,  A61K31/497 ,  A61K38/21 ,  A61K38/55 ,  C07H19/16 ,  A61K31/7056

Abstract: Provided herein are compounds, compositions and methods for the treatment of liver disease and conditions, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

公开(公告)号：US10238680B2

公开(公告)日：2019-03-26

申请号：US14954815

申请日：2015-11-30

Applicant: IDENIX PHARMACEUTICALS LLC ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE MONTPELLIER

Inventor： Benjamin Alexander Mayes ,  Adel M. Moussa ,  Cyril B. Dousson ,  Gilles Gosselin ,  Claire Pierra ,  David Dukhan

IPC: C07H19/10 ,  A61K31/7068 ,  A61K31/7072 ,  A61K45/06 ,  A61K9/00

Abstract: Provided herein are compounds, compositions, and methods for the treatment of viral infections, for example, Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are D-amino acid phosphoramidate halogeno pyrimidine nucleoside analog compounds which display remarkable efficacy and bioavailability for the treatment of, for example, HCV infection in a human. In certain embodiments, the compounds are of Formula I: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof, wherein: PD, X, R1, R2, RA, and RB are as described herein.

公开(公告)号：US20180179208A1

公开(公告)日：2018-06-28

申请号：US15847971

申请日：2017-12-20

Applicant: Merck Sharp & Dohme Corp. ,  Idenix Pharmaceuticals LLC

Inventor： Jean-Laurent Paparin ,  Izzat Raheem ,  Houcine Rahali ,  Daniel Da Costa ,  David Dukhan

IPC: C07D473/34 ,  A61K31/52 ,  A61P31/18 ,  A61K45/06

Abstract: Compounds of Formula I: and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines

公开(公告)号：US10899788B2

公开(公告)日：2021-01-26

申请号：US16311363

申请日：2017-06-20

Applicant: Stephane Bogen ,  David Dukhan ,  Guillaume Brandt ,  Claire Pierra Rouviere ,  Cyril B. Dousson ,  Francois-Rene Alexandre ,  MERCK SHARP & DOHME CORP. ,  IDENIX PHARMACEUTICALS LLC

Inventor： Stephane Bogen ,  David Dukhan ,  Guillaume Brandt ,  Claire Pierra Rouviere ,  Cyril B. Dousson ,  Francois-Rene Alexandre

IPC: C07H19/11 ,  A61P31/14 ,  C07H19/213 ,  A61K45/06 ,  A61K31/7072 ,  A61K31/7076

Abstract: The present invention relates to Cyclic Phosphate Substituted Nucleoside Compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein in A, B, R1, R2, R3, Q and V are as defined herein. The present invention also relates to compositions comprising a Cyclic Phosphate Substituted Nucleoside Compound, and methods of using the Cyclic Phosphate Substituted Nucleoside Compounds for treating or preventing HCV infection in a patient.

公开(公告)号：US10766917B2

公开(公告)日：2020-09-08

申请号：US15576948

申请日：2016-05-23

Applicant: IDENIX PHARMACEUTICALS LLC

Inventor： Cyril B. Dousson ,  David Dukhan ,  Christophe Claude Parsy

IPC: C07H19/11 ,  C07H19/10 ,  A61P35/00

Abstract: The present invention relates to novel nucleoside derivatives, pharmaceutical compositions comprising the compounds, processes of preparation thereof, and methods of use thereof for treating cancer.

公开(公告)号：US10449208B2

公开(公告)日：2019-10-22

申请号：US16327631

申请日：2017-08-22

Applicant: Merck Sharp & Dohme Corp. ,  IDENIX PHARMACEUTICALS LLC

Inventor： Daniel Da Costa ,  Cyril B. Dousson ,  David Dukhan ,  Jean-Laurent Paparin ,  Houcine Rahali ,  Izzat Raheem

IPC: A61K31/675 ,  A61P31/12 ,  A61K45/00

Abstract: Compounds of Formula I: and pharmaceutically acceptable salts and co-crystals thereof are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.

公开(公告)号：US10030044B2

公开(公告)日：2018-07-24

申请号：US15039176

申请日：2014-11-25

Applicant: IDENIX PHARMACEUTICALS LLC

Inventor： Cyril B. Dousson ,  David Dukhan ,  Christophe Claude Parsy

IPC: A01N43/04 ,  A61K31/70 ,  C07H19/207 ,  A61K31/7076 ,  C07H19/16 ,  C07H19/06 ,  C07H19/10 ,  C07H19/20 ,  A61K31/7072 ,  A61K31/708 ,  A61K31/7068 ,  A61K31/706 ,  A61K31/7052 ,  A61K31/7064

Abstract: Provided herein are compounds, compositions and methods for the treatment of liver cancer such as hepatocellular carcinoma, cholangiocarcinoma, or biliary tract cancer. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-cancer agents. In certain embodiments, the compounds are nucleoside analogs of Formula I: (I); or a pharmaceutically acceptable salt thereof, wherein Base, Z1, Z2, Z3, Z4, V, W, X, Ar, R1 and R2 are as described herein.

公开(公告)号：US20180162898A1

公开(公告)日：2018-06-14

申请号：US15104706

申请日：2014-12-17

Applicant: IDENIX PHARMACEUTICALS LLC

Inventor： David Dukhan ,  Cyril B. Dousson ,  Adel M. Moussa ,  Benjamin Alexander Mayes ,  James Alistair Stewart

IPC: C07H19/207 ,  C07H19/10 ,  A61P31/14

CPC classification number: C07H19/207 ,  A61P31/14 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20

Abstract: Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 4′-OR nucleosides of Formula I: or a pharmaceutically acceptable salt thereof, wherein Base, PD, R, Z1, Z2, Z3, and Z4 are as defined herein.

公开(公告)号：US10815264B2

公开(公告)日：2020-10-27

申请号：US15576607

申请日：2016-05-25

Applicant: IDENIX PHARMACEUTICALS LLC ,  SOUTHERN RESEARCH INSTITUTE ,  Cyril B. Dousson ,  David Dukhan ,  Jean-Laurent Paparin ,  Christophe C. Parsy

Inventor： Cyril B. Dousson ,  David Dukhan ,  Jean-Laurent Paparin ,  Christophe C. Parsy

IPC: C07D409/04 ,  C07H19/10 ,  C07H19/11 ,  A61P35/02

Abstract: The present application relates to novel nucleoside derivatives of formula (I) as claimed in claim 1, pharmaceutical compositions comprising the compounds, processes of preparation thereof, and methods of use thereof for treating cancer.