公开(公告)号：US20240343707A1

公开(公告)日：2024-10-17

申请号：US18631992

申请日：2024-04-10

Applicant: Southern Research Institute ,  Oregon Health & Science University

Inventor： Syed Kaleem Ahmed ,  Shilpa Dutta ,  Daniel N. Streblow ,  Corinne E. Augelli-Szafran ,  Omar Moukha-Chafiq ,  Ali Nakhi ,  Ashish Kumar Pathak

IPC: C07D401/12 ,  A61K31/505 ,  A61K31/506 ,  A61K31/55 ,  A61K31/675 ,  A61P31/14 ,  C07D239/26 ,  C07D403/12 ,  C07D405/12 ,  C07D513/12 ,  C07F9/6512

CPC classification number: C07D401/12 ,  A61K31/505 ,  A61K31/506 ,  A61K31/55 ,  A61K31/675 ,  A61P31/14 ,  C07D239/26 ,  C07D403/12 ,  C07D405/12 ,  C07D513/12 ,  C07F9/6512

Abstract: The present disclosure is concerned with substituted phenyl ethynyl pyrimidine compounds that are capable of inhibiting a viral infection and methods of treating alphavirus viral infections such as, for example, chikungunya, Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), and Venezuelan equine encephalitis using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US11945781B2

公开(公告)日：2024-04-02

申请号：US18183281

申请日：2023-03-14

Applicant: Southern Research Institute ,  UAB Research Foundation ,  The United States Government as Represented by the Department of Veterans Affairs

Inventor： Mark J. Suto ,  Bini Mathew ,  Anupam Agarwal ,  Amie M. Traylor

IPC: C07D215/36 ,  C07C321/28 ,  C07D213/70 ,  C07D215/40 ,  C07D215/48 ,  C07D217/22

CPC classification number: C07D215/36 ,  C07C321/28 ,  C07D213/70 ,  C07D215/40 ,  C07D215/48 ,  C07D217/22

Abstract: The present disclosure is concerned with thioquinolinone compounds for the treatment of disorders associated with heme oxygenase-1 (HO-1) signaling dysfunction such as, for example, kidney diseases (e.g., chronic kidney disease, acute kidney injury). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US11932626B2

公开(公告)日：2024-03-19

申请号：US18080692

申请日：2022-12-13

Applicant: Southern Research Institute ,  Oregon Health and Science University

Inventor： Ashish Kumar Pathak ,  Corinne E. Augelli-Szafran ,  Atefeh Garzan ,  Daniel Steblow ,  Nicole Haese

IPC: C07D403/04 ,  C07D213/69 ,  C07D213/70 ,  C07D213/74 ,  C07D491/052 ,  C07D498/08

CPC classification number: C07D403/04 ,  C07D213/69 ,  C07D213/70 ,  C07D213/74 ,  C07D491/052 ,  C07D498/08

Abstract: The present disclosure is concerned with 2-pyrimidone compounds that are capable of inhibiting a viral infection and methods of treating alphavirus viral infections such as, for example, chikungunya, Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), and Venezuelan equine encephalitis using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US11905258B2

公开(公告)日：2024-02-20

申请号：US17893091

申请日：2022-08-22

Applicant: Southern Research Institute

Inventor： Mark J. Suto ,  Bini Mathew ,  Rita Cowell ,  Corinne E. Augelli-Szafran

IPC: C07D263/48 ,  C07D413/04

CPC classification number: C07D263/48 ,  C07D413/04

Abstract: The present disclosure is concerned with 2-aminoaryl-5-aryloxazole compounds that are capable of activating NF-κB signaling. The present disclosure is also concerned with methods of using these compounds for the treatment of neurological disorders such as, for example, amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, spinal muscular atrophy, traumatic brain injury, vascular dementia, Huntington's disease, mental retardation, and attention deficit and hyperactivity disorder (ADHD), and neuromuscular disorders such as, for example, Duchenne muscular dystrophy (DMD). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20230416231A1

公开(公告)日：2023-12-28

申请号：US18114977

申请日：2023-02-27

Applicant: Southern Research Institute ,  UAB Research Foundation

Inventor： Kevin Jay Rodzinak ,  Terry Smalley ,  Robert Hunter ,  John P. Tillotson ,  Corinne E. Augelli-Szafran ,  Bini Mathew ,  David Bedwell ,  Steven Rowe

IPC: C07D403/06 ,  C07D403/14 ,  C07D413/14 ,  C07D409/14 ,  C07D417/14

CPC classification number: C07D403/06 ,  C07D403/14 ,  C07D417/14 ,  C07D409/14 ,  C07D413/14

Abstract: The present disclosure is concerned with substituted uracil compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders associated with the presence of a premature termination codon such as, for example, cystic fibrosis, Duchenne muscular dystrophy, aniridia, Becker muscular dystrophy, spinal muscular atrophy, Hurler syndrome, hemophilia, epidermolysis bullosa (e.g., dystrophic (DEB) form, junctional (JEB) form), Usher syndrome, and cancer, using the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20230286933A1

公开(公告)日：2023-09-14

申请号：US18198088

申请日：2023-05-16

Applicant: Southern Research Institute

Inventor： Mark J. Suto ,  Bini Mathew ,  Rita Cowell ,  Corinne E. Augelli-Szafran

IPC: C07D277/42 ,  A61P25/28 ,  C07D277/22 ,  C07D277/30 ,  C07D317/58 ,  C07D417/10 ,  C07D417/14

CPC classification number: C07D277/42 ,  A61P25/28 ,  C07D277/22 ,  C07D277/30 ,  C07D317/58 ,  C07D417/10 ,  C07D417/14

Abstract: The present disclosure is concerned with 2,5-amino-thiazole compounds that are capable of activating NF-κB signaling. The present disclosure is also concerned with methods of using these compounds for the treatment of neurological disorders such as, for example, amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, spinal muscular atrophy, traumatic brain injury, vascular dementia, Huntington's disease, mental retardation, and attention deficit and hyperactivity disorder (ADHD), and neuromuscular disorders such as, for example, Duchenne muscular dystrophy (DMD). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20230120566A1

公开(公告)日：2023-04-20

申请号：US18080692

申请日：2022-12-13

Applicant: Southern Research Institute ,  Oregon Health and Science University

Inventor： Ashish Kumar Pathak ,  Corinne E. Augelli-Szafran ,  Atefeh Garzan ,  Daniel Steblow ,  Nicole Haese

IPC: C07D403/04 ,  C07D213/69 ,  C07D213/70 ,  C07D213/74 ,  C07D491/052 ,  C07D498/08

Abstract: The present disclosure is concerned with 2-pyrimidone compounds that are capable of inhibiting a viral infection and methods of treating alphavirus viral infections such as, for example, chikungunya, Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), and Venezuelan equine encephalitis using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US11623918B2

公开(公告)日：2023-04-11

申请号：US17529201

申请日：2021-11-17

Applicant: Southern Research Institute ,  UAB Research Foundation ,  The United States Government as Represented by the Department of Veterans Affairs

Inventor： Mark J. Suto ,  Bini Mathew ,  Anupam Agarwal ,  Amie M. Traylor

IPC: C07D215/36 ,  C07D215/40 ,  C07D215/48 ,  C07D213/70 ,  C07D217/22 ,  C07C321/28

Abstract: The present disclosure is concerned with thioquinolinone compounds for the treatment of disorders associated with heme oxygenase-1 (HO-1) signaling dysfunction such as, for example, kidney diseases (e.g., chronic kidney disease, acute kidney injury). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US11566019B2

公开(公告)日：2023-01-31

申请号：US17221666

申请日：2021-04-02

Applicant: Southern Research Institute ,  Oregon Health and Science University

Inventor： Ashish Kumar Pathak ,  Corinne E. Augelli-Szafran ,  Atefeh Garzan ,  Daniel Streblow ,  Nicole Haese

IPC: C07D403/04 ,  C07D213/69 ,  C07D213/70 ,  C07D213/74 ,  C07D491/052 ,  C07D498/08

Abstract: The present disclosure is concerned with 2-pyrimidone compounds that are capable of inhibiting a viral infection and methods of treating alphavirus viral infections such as, for example, chikungunya, Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), and Venezuelan equine encephalitis using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20220204545A1

公开(公告)日：2022-06-30

申请号：US17554979

申请日：2021-12-17

Applicant: Southern Research Institute ,  Oregon Health & Science University ,  Washington University in St. Louis ,  Board of Regents of the University of Texas System and Its Component Institution University of Texas

Inventor： Omar Moukha-Chafiq ,  Ashish Kumar Pathak ,  Shuklendu D. Karyakarte ,  Larry D. Bratton ,  Corinne E. Augelli-Szafran ,  Michael Diamond ,  Pei Yong Shi ,  Alec Jay Hirsch ,  Jessica Lee Smith ,  Daniel Streblow ,  Nicole Haese ,  Baoling Ying

IPC: C07H19/12 ,  A61P31/16 ,  A61P31/14

Abstract: The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.