公开(公告)号：US20180162898A1

公开(公告)日：2018-06-14

申请号：US15104706

申请日：2014-12-17

Applicant: IDENIX PHARMACEUTICALS LLC

Inventor： David Dukhan ,  Cyril B. Dousson ,  Adel M. Moussa ,  Benjamin Alexander Mayes ,  James Alistair Stewart

IPC: C07H19/207 ,  C07H19/10 ,  A61P31/14

CPC classification number: C07H19/207 ,  A61P31/14 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20

Abstract: Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 4′-OR nucleosides of Formula I: or a pharmaceutically acceptable salt thereof, wherein Base, PD, R, Z1, Z2, Z3, and Z4 are as defined herein.