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    Combination stirrer
    2.
    发明授权
    Combination stirrer 有权

    公开(公告)号：US11253826B2

    公开(公告)日：2022-02-22

    申请号：US16103341

    申请日：2018-08-14

    Applicant: HOFFMANN-LA ROCHE INC.

    Inventor： Marco Jenzsch ,  Max Lechner ,  Michael Pohlscheidt ,  Christoph Reese ,  Alexander Scholz ,  Hermann Tebbe

    IPC: B01F7/00 ,  C12M1/06

    Abstract: The present patent application describes a stirrer comprising a combination of at least one axially-conveying element and at least one radially-conveying element relative to the rotary shaft of the stirrer wherein the largest diameter of the at least one axially-conveying element is equal to or less than the inner diameter di of the radially-conveying element. In one embodiment the stirrer according to the invention is a combination of one anchor stirrer with at least one inclined-blade stirrer. Furthermore the use of the stirrer according to the invention for the culture of cells in a dialysis method is described.

    STIRRER SYSTEM
    4.
    发明申请
    STIRRER SYSTEM 审中-公开
    STIRRER系统

    公开(公告)号：US20150175952A1

    公开(公告)日：2015-06-25

    申请号：US14554749

    申请日：2014-11-26

    Applicant: Hoffmann-La Roche Inc.

    Inventor： Alexander Alisch ,  Marco Jenzsch ,  Michael Pohlscheidt ,  Joerg Thiele ,  Claus Wallerius

    IPC: C12M1/06 ,  C07K16/40 ,  C07K16/28 ,  B01F7/16 ,  C12N5/071

    CPC classification number: C12M27/02 ,  B01F7/00241 ,  B01F7/00341 ,  B01F7/00383 ,  B01F7/00466 ,  B01F7/00641 ,  B01F7/1625 ,  B01F2215/0073 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/40 ,  C07K2317/14 ,  C12M27/08 ,  C12N5/0602

    Abstract: The present invention concerns a stirrer system for animal cell culture consisting of a combination of at least one radially-conveying stirrer element and at least one axially-conveying stirrer element, wherein at least three stirrer elements must be present and the uppermost stirrer element is an axially-conveying stirrer element. The stirrer elements are arranged at a certain distance above one another on a stirrer shaft. A particular embodiment is a multiple stirrer system consisting of two disk stirrers as radially-conveying stirrer elements and an inclined-blade stirrer as an axially-conveying stirrer element wherein the inclined-blade stirrer is arranged above the disk stirrer on the stirrer shaft. The stirrer system according to the invention achieves among others a gentler and better intermixing in the culture of shear-sensitive mammalian cells in cell cultures.

    Abstract translation: 本发明涉及用于动物细胞培养的搅拌器系统，其由至少一个径向输送的搅拌器元件和至少一个轴向输送的搅拌器组件的组合组成，其中必须存在至少三个搅拌器元件，最上面的搅拌器元件是 轴向输送搅拌器元件。 搅拌器元件在搅拌器轴上相互一定距离地布置。 一个具体的实施方案是多个搅拌器系统，其由作为径向输送搅拌器元件的两个盘式搅拌器和作为轴向输送搅拌器元件的倾斜叶片搅拌器组成，其中倾斜叶片搅拌器设置在搅拌器轴上的盘式搅拌器上方。 根据本发明的搅拌器系统尤其实现了在细胞培养物中对剪切敏感的哺乳动物细胞的培养中更温和和更好的混合。

    SEPARATION APPARATUS AND USE THEREOF
    5.
    发明申请
    SEPARATION APPARATUS AND USE THEREOF 审中-公开
    分离装置及其使用

    公开(公告)号：US20140057344A1

    公开(公告)日：2014-02-27

    申请号：US13942661

    申请日：2013-07-15

    Applicant: Hoffmann-La Roche Inc.

    Inventor： Oskar Brauner-Sreuther ,  Alexander Jockwear ,  Torsten Klabuhn ,  Michael Pohlscheidt ,  Joerg Thiele

    IPC: B01D21/00 ,  C12M1/26

    CPC classification number: B01D21/0042 ,  B01D21/0045 ,  B01D21/0057 ,  B01D2221/06 ,  C12M27/02 ,  C12M27/20 ,  C12M33/22 ,  C12M47/02

    Abstract: Separating apparatus, comprising a sedimentation settler and a collection vessel disposed underneath and being in fluid communication with the sedimentation settler, the collection vessel forming a receiving chamber having an outlet at or adjacent to the chamber bottom and having an inlet opening, wherein the collection vessel is arranged such the flow direction of the fluid in the area underneath the sedimentation settler is substantially in line with the direction of the channels of the sedimentation settler.

    Abstract translation: 分离装置，包括沉降沉降器和设置在沉降沉降器下面并与沉降沉降器流体连通的收集容器，收集容器形成容纳室，该容纳室具有在室底部或邻近室底部的出口，并具有入口开口，其中采集容器 布置成使得在沉降沉降器下面的区域中的流体的流动方向基本上与沉降沉降器的通道的方向一致。

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