公开(公告)号：US5468141A

公开(公告)日：1995-11-21

申请号：US182494

申请日：1994-01-18

申请人： Hiroyuki Iwami ,  Masayoshi Fukuoka ,  Hiroyuki Kanayama

发明人： Hiroyuki Iwami ,  Masayoshi Fukuoka ,  Hiroyuki Kanayama

IPC分类号： B29C33/28 ,  B29C33/42 ,  B29C33/76 ,  B29C45/26 ,  B29C45/37 ,  B29C45/03

CPC分类号： B29C33/3828 ,  B29C33/56 ,  B29C45/37 ,  B29K2883/00

摘要： A mold for injection molding of a thermoplastic resin. The mold comprises a cavity block, a core block, and a cavity formed between the cavity block and the core block and adapted to be filled with a molten resin. The cavity block includes an insulating layer on a cavity side thereof, the insulating layer being made of a material selected from the group consisting of ceramic materials, porcelain enamel, glass materials, heat resistant plastic materials and their composites. The core block includes a release insulating layer on a cavity side thereof, the release insulating layer being made of a material selected from the group consisting of fluorocarbon resins, fluorocarbon resin composite materials, silicone resin composite materials and metal platings with fluorocarbon resin dispersion, the release insulating layer further being adapted to effect both mold releasing and heat insulation.

摘要翻译： 一种用于注塑热塑性树脂的模具。 模具包括空腔块，芯块和形成在空腔块和芯块之间并适于填充熔融树脂的空腔。 空腔块在其空腔侧上包括绝缘层，绝缘层由选自陶瓷材料，瓷搪瓷，玻璃材料，耐热塑料材料及其复合材料的材料制成。 芯块包括在其空腔侧的释放绝缘层，释放绝缘层由选自氟碳树脂，氟碳树脂复合材料，硅树脂复合材料和具有氟碳树脂分散体的金属电镀组成的组中的材料制成， 释放绝缘层还适于实现脱模和隔热。

公开(公告)号：US20110082163A1

公开(公告)日：2011-04-07

申请号：US12996079

申请日：2009-06-02

申请人： Masayoshi Fukuoka ,  Tatsushi Yokogawa ,  Seiji Miyahara ,  Hitoshi Miyakoshi ,  Wakako Yano ,  Junko Taguchi ,  Yayoi Takao

发明人： Masayoshi Fukuoka ,  Tatsushi Yokogawa ,  Seiji Miyahara ,  Hitoshi Miyakoshi ,  Wakako Yano ,  Junko Taguchi ,  Yayoi Takao

IPC分类号： A61K31/513 ,  C07D239/54 ,  C07D405/12 ,  C07D409/12 ,  C07D403/12 ,  C07D401/06 ,  A61P35/00

CPC分类号： C07D239/48 ,  C07D239/46 ,  C07D401/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12

摘要： Provided is a uracil compound or a salt thereof, which has potent human dUTPase inhibitory activity and is useful as, for example, an antitumor drug.A uracil compound represented by the general formula (I) or a salt thereof: wherein n represents an integer of 1 to 3; X represents a bond, an oxygen atom, a sulfur atom, or the like; Y represents a linear or branched alkylene group having 1 to 8 carbon atoms, or the like; and Z represents —SO2NR1R2 or —NR3SO2—R4, wherein R1 and R2 each represent an alkyl group having 1 to 6 carbon atoms, an aralkyl group which is optionally substituted, or the like; R3 represents an alkyl group having 1 to 6 carbon atoms, or the like; and R4 represents an aromatic hydrocarbon group, an unsaturated heterocyclic group, or the like.

摘要翻译： 本发明提供尿嘧啶化合物或其盐，其具有强的人dUTP酶抑制活性，可用作例如抗肿瘤药物。 由通式（I）表示的尿嘧啶化合物或其盐：其中n表示1〜3的整数， X表示键，氧原子，硫原子等; Y表示碳原子数1〜8的直链或支链亚烷基等。 Z表示-SO 2 NR 1 R 2或-NR 3 SO 2 -R 4，其中，R 1和R 2各自表示碳原子数1〜6的烷基，可以具有取代基的芳烷基等。 R3表示碳原子数1〜6的烷基等。 R 4表示芳香族烃基，不饱和杂环基等。

公开(公告)号：US5223218A

公开(公告)日：1993-06-29

申请号：US179645

申请日：1988-04-08

申请人： Masayoshi Fukuoka ,  Akira Matsuyuki

发明人： Masayoshi Fukuoka ,  Akira Matsuyuki

IPC分类号： G01N21/03 ,  G01N21/76

CPC分类号： G01N21/76 ,  G01N2021/0375 ,  G01N2201/0231 ,  G01N2201/0253 ,  G01N2201/0648

摘要： An instrument for quantitative analysis includes two shutters, one of which prevents light from being introduced into a black box housing a cell holder from the outside through a port in which a cell may be placed in and taken out the black box, and the other of which prevents light from impinging on a photomultiplier tube which is in communication with the black box. The shutters are controlled by a control unit so that one of the shutters opens when the other closes. The instrument also includes detectors which detect whether or not the cell holder and the cell are disposed at predetermined positions, respectively. The detectors output signals to the control unit. The control unit controls an automatic pipetting device to restrict a sample from being introduced into the cell when both the cell holder and the cell are not disposed at the predetermined position.

公开(公告)号：US20120225838A1

公开(公告)日：2012-09-06

申请号：US13509102

申请日：2010-11-29

申请人： Masayoshi Fukuoka ,  Tatsushi Yokogawa ,  Seiji Miyahara ,  Hitoshi Miyakoshi ,  Wakako Yano ,  Junko Taguchi ,  Yayoi Takao

发明人： Masayoshi Fukuoka ,  Tatsushi Yokogawa ,  Seiji Miyahara ,  Hitoshi Miyakoshi ,  Wakako Yano ,  Junko Taguchi ,  Yayoi Takao

IPC分类号： A61K31/513 ,  A61K31/7072 ,  A61K31/519 ,  C07D239/54 ,  A61P35/00

CPC分类号： C07D239/54 ,  A61K31/513 ,  A61K31/519 ,  A61K31/7072 ,  A61K45/06 ,  C07D405/12 ,  A61K2300/00

摘要： There is provided an agent for potentiating the effects of an anti-tumor agent.An anti-tumor effect potentiator containing, as an active ingredient, a uracil compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein X represents a C1-5 alkylene group and one of methylene groups constituting the alkylene group is optionally substituted with an oxygen atom; R1 represents a hydrogen atom or a C1-6 alkyl group; R2 represents a hydrogen atom or a halogen atom; and R3 represents a C1-6 alkyl group, a C2-6 alkenyl group, a C3-6 cycloalkyl group, a (C3-6 cycloalkyl) C1-6 alkyl group, a halogeno-C1-6 alkyl group or a saturated heterocyclic group.

摘要翻译： 提供了增强抗肿瘤剂效果的药剂。 一种抗肿瘤效果增强剂，其含有下式（I）表示的尿嘧啶化合物或其药学上可接受的盐作为活性成分：其中X表示C1-5亚烷基，构成亚烷基的亚甲基之一为 任选被氧原子取代; R1表示氢原子或C1-6烷基; R2表示氢原子或卤素原子; R 3表示C 1-6烷基，C 2-6烯基，C 3-6环烷基，（C 3-6环烷基）C 1-6烷基，卤代C 1-6烷基或饱和杂环基 。

公开(公告)号：US08883759B2

公开(公告)日：2014-11-11

申请号：US13509102

申请日：2010-11-29

申请人： Masayoshi Fukuoka ,  Tatsushi Yokogawa ,  Seiji Miyahara ,  Hitoshi Miyakoshi ,  Wakako Yano ,  Junko Taguchi ,  Yayoi Takao

发明人： Masayoshi Fukuoka ,  Tatsushi Yokogawa ,  Seiji Miyahara ,  Hitoshi Miyakoshi ,  Wakako Yano ,  Junko Taguchi ,  Yayoi Takao

IPC分类号： A61K31/513 ,  A61K31/7072 ,  A61K31/519 ,  C07D239/54 ,  A61P35/00 ,  A61K45/06 ,  C07D405/12

CPC分类号： C07D239/54 ,  A61K31/513 ,  A61K31/519 ,  A61K31/7072 ,  A61K45/06 ,  C07D405/12 ,  A61K2300/00

摘要： There is provided an agent for potentiating the effects of an anti-tumor agent.An anti-tumor effect potentiator containing, as an active ingredient, a uracil compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein X represents a C1-5 alkylene group and one of methylene groups constituting the alkylene group is optionally substituted with an oxygen atom; R1 represents a hydrogen atom or a C1-6 alkyl group; R2 represents a hydrogen atom or a halogen atom; and R3 represents a C1-6 alkyl group, a C2-6 alkenyl group, a C3-6 cycloalkyl group, a (C3-6 cycloalkyl) C1-6 alkyl group, a halogeno-C1-6 alkyl group or a saturated heterocyclic group.

摘要翻译： 提供了增强抗肿瘤剂效果的药剂。 一种抗肿瘤效果增强剂，其含有下式（I）表示的尿嘧啶化合物或其药学上可接受的盐作为活性成分：其中X表示C1-5亚烷基，构成亚烷基的亚甲基之一为 任选被氧原子取代; R1表示氢原子或C1-6烷基; R2表示氢原子或卤素原子; R 3表示C 1-6烷基，C 2-6烯基，C 3-6环烷基，（C 3-6环烷基）C 1-6烷基，卤代C 1-6烷基或饱和杂环基 。

公开(公告)号：US08530490B2

公开(公告)日：2013-09-10

申请号：US12996079

申请日：2009-06-02

申请人： Masayoshi Fukuoka ,  Tatsushi Yokogawa ,  Seiji Miyahara ,  Hitoshi Miyakoshi ,  Wakako Yano ,  Junko Taguchi ,  Yayoi Takao

发明人： Masayoshi Fukuoka ,  Tatsushi Yokogawa ,  Seiji Miyahara ,  Hitoshi Miyakoshi ,  Wakako Yano ,  Junko Taguchi ,  Yayoi Takao

IPC分类号： A61K31/505 ,  C07D401/02 ,  C07D239/02

CPC分类号： C07D239/48 ,  C07D239/46 ,  C07D401/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12

摘要： Provided is a uracil compound or a salt thereof, which has potent human dUTPase inhibitory activity and is useful as, for example, an antitumor drug.A uracil compound represented by the general formula (I) or a salt thereof: wherein n represents an integer of 1 to 3; X represents a bond, an oxygen atom, a sulfur atom, or the like; Y represents a linear or branched alkylene group having 1 to 8 carbon atoms, or the like; and Z represents —SO2NR1R2 or —NR3SO2—R4, wherein R1 and R2 each represent an alkyl group having 1 to 6 carbon atoms, an aralkyl group which is optionally substituted, or the like; R3 represents an alkyl group having 1 to 6 carbon atoms, or the like; and R4 represents an aromatic hydrocarbon group, an unsaturated heterocyclic group, or the like.

摘要翻译： 本发明提供尿嘧啶化合物或其盐，其具有强的人dUTP酶抑制活性，可用作例如抗肿瘤药物。 由通式（I）表示的尿嘧啶化合物或其盐：其中n表示1〜3的整数， X表示键，氧原子，硫原子等; Y表示碳原子数1〜8的直链或支链亚烷基等。 Z表示-SO 2 NR 1 R 2或-NR 3 SO 2 -R 4，其中，R 1和R 2各自表示碳原子数1〜6的烷基，可以具有取代基的芳烷基等。 R3表示碳原子数1〜6的烷基等。 R 4表示芳香族烃基，不饱和杂环基等。