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公开(公告)号：US09796831B2
公开(公告)日：2017-10-24
申请号：US14114682
申请日：2012-04-24
IPC分类号： C08K3/34 , C08K5/41 , C07C381/02
CPC分类号： C08K5/41 , C07C381/02 , Y10T428/1386 , Y10T428/24479 , Y10T428/296 , C08L21/00
摘要： A process for producing particles, the process including pulverizing particles of a compound represented by formula (I) with a median diameter (50% D) of over 100 μm by using a pulverizer in the presence of at least one member selected from the group consisting of silica, talc and clay, to obtain particles of the compound represented by formula (I) with a median diameter (50% D) of 100 μm or less, in formula (I), R1 and R2 each independently represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, or alternatively, R1 and R2 are inked to each other to form a ring together with the nitrogen atom to which they are bound, m represents an integer of 2 to 9, Mn+ represents H+ or an n-valent metal ion, and n represents an integer of 1 or 2.
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公开(公告)号：US20140065337A1
公开(公告)日：2014-03-06
申请号：US14114682
申请日：2012-04-24
IPC分类号： C08K5/41
CPC分类号： C08K5/41 , C07C381/02 , Y10T428/1386 , Y10T428/24479 , Y10T428/296 , C08L21/00
摘要： A process for producing particles, the process including pulverizing particles of a compound represented by formula (I) with a median diameter (50% D) of over 100 μm by using a pulverizer in the presence of at least one member selected from the group consisting of silica, talc and clay, to obtain particles of the compound represented by formula (I) with a median diameter (50% D) of 100 μm or less, in formula (I), R1 and R2 each independently represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, or alternatively, R1 and R2 are inked to each other to form a ring together with the nitrogen atom to which they are bound, m represents an integer of 2 to 9, Mn+ represents H+ or an n-valent metal ion, and n represents an integer of 1 or 2.
摘要翻译： 一种生产颗粒的方法，该方法包括在选自以下的至少一种的存在下，使用粉碎机将中等直径（50％D）超过100μm的由式（I）表示的化合物的颗粒粉碎， 的二氧化硅，滑石和粘土，以得到式（I）中的中值粒径（50％D）为100摩尔的式（I）表示的化合物的颗粒，R1和R2各自独立地表示氢原子或 具有1至6个碳原子的烷基，或者R1和R2彼此连接形成环，与它们所键合的氮原子一起形成环，m表示2至9的整数，Mn +表示H +或 n价金属离子，n表示1或2的整数。
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3.发明授权Crystalline or crystallized acid addition salt of losartan and purification method of losartan 失效氯沙坦的结晶或结晶酸加成盐和氯沙坦的纯化方法公开(公告)号：US06350880B1
公开(公告)日：2002-02-26
申请号：US09714339
申请日：2000-11-16
IPC分类号： C07D25704
CPC分类号： C07D403/10
摘要： The present invention provides a crystalline or crystallized acid addition salt of Losartan useful for obtaining highly pure 2-n-butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol (Losartan), and a purification method of Losartan that includes production of the crystalline or crystallized acid addition salt.
摘要翻译： 本发明提供了一种用于获得高纯度2-正丁基-4-氯-1 - [[2' - （1H-四唑-5-基）[1,1'- 联苯] -4-基]甲基] -1H-咪唑-5-甲醇（氯沙坦）和氯沙坦的纯化方法，包括生成结晶或结晶的酸加成盐。
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公开(公告)号：US06441187B1
公开(公告)日：2002-08-27
申请号：US09901077
申请日：2001-07-09
IPC分类号： C07D27506
CPC分类号： C07D275/06
摘要： A method for producing camphorsultam, which includes the following steps 1 to 4: Step 1: reacting camphorsulfonic acid with a halogenation agent to give camphorsulfonyl halide, Step 2: reacting the camphorsulfonyl halide with ammonia to give camphorsulfonamide, Step 3: subjecting the camphorsulfonamide to dehydration and ring closure to give camphorsulfonimine, and Step 4: reducing the camphorsulfonimine with sodium borohydride in an aqueous isopropanol solution. According to this invention, camphorsultam and intermediates thereof can be obtained by an industrial method which is comparatively safe to the environment and human body, economical, and which is simple and easy.
摘要翻译： 制备樟脑磺酸的方法，其包括以下步骤1至4：步骤1：使樟脑磺酸与卤化剂反应得到樟脑磺酰卤，步骤2：使樟脑磺酰卤与氨反应得到樟脑磺酰胺，步骤3：使樟脑磺酰胺 脱水和闭环以得到樟脑磺酰亚胺，步骤4：用异丙醇水溶液中的硼氢化钠还原樟脑磺胺。 根据本发明，樟脑磺胺及其中间体可以通过对环境和人体相对安全的工业方法获得，经济且简单易行。
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公开(公告)号：US5998652A
公开(公告)日：1999-12-07
申请号：US009823
申请日：1998-01-20
IPC分类号： C07C253/30 , C07C255/50 , C07C255/00
CPC分类号： C07C253/30
摘要： A process for preparing a 2-cyanobiphenyl compound represented by the formula (II): ##STR1## wherein R.sup.1 is an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, or hydrogen atom, from a phenylmagnesium chloride compound represented by the formula (I): ##STR2## wherein R.sup.1 is as defined above. According to the process, a 2-cyanobiphenyl compound represented by the formula (II) can be economically, simply, industrially and advantageously prepared.
摘要翻译： 一种由式（II）表示的2-氰基联苯化合物的制备方法，其中R 1是具有1至6个碳原子的烷基，具有1至6个碳原子的烷氧基或氢原子，由代表的苯基氯化镁化合物 由式（I）表示：其中R1如上所定义。 根据该方法，由式（II）表示的2-氰基联苯化合物可以在经济上简单地在工业上有利地制备。
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公开(公告)号：US5892094A
公开(公告)日：1999-04-06
申请号：US996341
申请日：1997-12-22
IPC分类号： C07C253/30 , C07C255/50 , C07C255/00
CPC分类号： C07C253/30
摘要： Process for preparing 4'-methyl-2-cyanobiphenyl, comprising, catalytically hydrogenating at least one brominated cyanobiphenyl compound selected from 4'-dibromomethyl-2-cyanobiphenyl and 4'-bromomethyl-2-cyanobiphenyl; and process for regenerating 4'-methyl-2-cyanobiphenyl, comprising, catalytically hydrogenating at least one brominated cyanobiphenyl compound selected from 4'-dibromomethyl-2-cyanobiphenyl and 4'-bromomethyl-2-cyanobiphenyl, contained in a filtrate prepared by brominating 4'-methyl-2-cyanobiphenyl in a solvent; crystallizing 4'-bromomethyl-2-cyanobiphenyl from the resulting reaction mixture; and removing the resulting crystals from the reaction mixture by filtration. 4'-Methyl-2-cyanobiphenyl can be used as starting materials for 4'-bromomethyl-2-cyanobiphenyl.
摘要翻译： 制备4'-甲基-2-氰基联苯的方法，包括催化氢化至少一种选自4'-二溴甲基-2-氰基联苯和4'-溴甲基-2-氰基联苯的溴代氰基联苯化合物; 以及用于再生4'-甲基-2-氰基联苯的方法，包括催化氢化选自4-溴 - 二溴甲基-2-氰基联苯和4'-溴甲基-2-氰基联苯中的至少一种溴化氰基联苯化合物，其包含在通过溴化制备的滤液中 4'-甲基-2-氰基联苯; 从所得反应混合物中结晶出4'-溴甲基-2-氰基联苯; 并通过过滤从反应混合物中除去所得晶体。 4'-甲基-2-氰基联苯可用作4'-溴甲基-2-氰基联苯的原料。
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公开(公告)号：US5621134A
公开(公告)日：1997-04-15
申请号：US543948
申请日：1995-10-17
申请人： Tadashi Katsura , Hiroshi Shiratani
发明人： Tadashi Katsura , Hiroshi Shiratani
IPC分类号： C07C253/30 , C07C255/50
CPC分类号： C07C253/30
摘要： A method for producing 4'-bromomethyl-2-cyanobiphenyl by the step of treating 4'-methyl-2-cyanobiphenyl with Br.sub.2 in a halogenated hydrocarbon solvent or an alkane solvent having 5 to 7 carbon atoms.
摘要翻译： 通过在卤代烃溶剂或具有5至7个碳原子的烷烃溶剂中用Br 2处理4'-甲基-2-氰基联苯的步骤制备4'-溴甲基-2-氰基联苯的方法。
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