公开(公告)号：US07498292B2

公开(公告)日：2009-03-03

申请号：US10637940

申请日：2003-08-08

Applicant: Hiroaki Suga ,  Yigong Bu

Inventor： Hiroaki Suga ,  Yigong Bu

IPC: C40B40/02

CPC classification number: C07D285/13 ,  C07C235/74 ,  C07C237/42 ,  C07C2601/08 ,  C07C2601/14 ,  C07D309/10 ,  C07D319/06 ,  Y02P20/582

Abstract: The present invention relates to solid phase or solution phase combinatorial libraries of autoinducer analogs. The present invention also relates to autoinducer agonists and antagonists. In addition, the present invention relates to methods for identifying autoinducer agonists and antagonists, as well as methods for regulating the activity of an autoinducer receptor, regulating biofilm formation, regulating growth or virulence of an organism in a subject, inhibiting the quorum sensing mechanism of an organism, and treating an infection in a subject caused by an organism possessing a quorum sensing mechanism which use the autoinducer analogs of the present invention.

Abstract translation: 本发明涉及自动诱导剂类似物的固相或溶液相组合文库。 本发明还涉及自体诱导剂激动剂和拮抗剂。 此外，本发明还涉及用于鉴定自身诱导剂激动剂和拮抗剂的方法，以及用于调节自身诱导剂受体活性的方法，调节生物膜形成，调节受试者中生物体的生长或毒力，抑制群体感受机制 一种有机体，并且治疗由具有本发明的自动诱导剂类似物的具有群体感应机制的生物体引起的受试者感染。